Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms

Fischer, Nicholas O.; Tarasow, Theodore M.; Tok, Jeffrey B.‐H.

doi:10.1039/b615477h

Cited by 23 publications

(13 citation statements)

References 54 publications

(86 reference statements)

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“…These have been based upon a number of principles including optical, electromechanical, acoustic, piezoelectric, magnetic and mass spectrometric. [11][12][15][16]. Although these are well established techniques, it may be possible to derive improved methods by studying nature.…”

Section: Sensor Element Transductionmentioning

confidence: 98%

Material requirements for bio-inspired sensing systems

Biggins

Lloyd

Salmond

et al. 2008

Optical Materials in Defence Systems Technology V

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The aim of developing bio-inspired sensing systems is to try and emulate the amazing sensitivity and specificity observed in the natural world. These capabilities have evolved, often for specific tasks, which provide the organism with an advantage in its fight to survive and prosper. Capabilities cover a wide range of sensing functions including vision, temperature, hearing, touch, taste and smell. For some functions, the capabilities of natural systems are still greater than that achieved by traditional engineering solutions; a good example being a dog's sense of smell. Furthermore, attempting to emulate aspects of biological optics, processing and guidance may lead to more simple and effective devices. A bio-inspired sensing system is much more than the sensory mechanism. A system will need to collect samples, especially if pathogens or chemicals are of interest. Other functions could include the provision of power, surfaces and receptors, structure, locomotion and control. In fact it is possible to conceive of a complete bio-inspired system concept which is likely to be radically different from more conventional approaches. This concept will be described and individual component technologies considered.

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Section: Sensor Element Transductionmentioning

confidence: 98%

Material requirements for bio-inspired sensing systems

Biggins

Lloyd

Salmond

et al. 2008

Optical Materials in Defence Systems Technology V

View full text Add to dashboard Cite

show abstract

“…The anthrax attacks in 2001 increased the interest in real-time detection of biological warfare agents, with immunoassay methods being increasingly utilized for that purpose. (1) Another approach may utilize direct-reading instruments to identify areas of concern within a facility to optimize a future sampling strategy requiring more sophisticated methods or instruments. One example was work conducted by Methner and Bowman, (2) who used a structured walk-through survey format to evaluate ambient magnetic fields in 62 industrial facilities to identify those with the highest readings for later, more extensive evaluation.…”

Section: Hazard Screeningmentioning

confidence: 99%

Analytical Performance Issues

Pearce

Coffey

2011

Journal of Occupational and Environmental Hygiene

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“…Readers interested in these sensors are referred to the literature for reviews on NP-based diagnostic assay. 49,[78][79][80]…”

Section: Np Sensors For Large Biological Moleculesmentioning

confidence: 99%

Optical nanoparticle sensors for quantitative intracellular imaging

Lee

Kopelman

2008

WIREs Nanomed Nanobiotechnol

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Real-time measurements of biological/chemical/physical processes, with no interferences, are an ultimate goal for in vivo intracellular studies. To construct intracellular biosensors that meet such a goal, nanoparticle (NP) platforms seem to be most promising, because of their small size and excellent engineerability. This review describes the development of NP-based opical sensors and their intracellular applications. The sensor designs are classified into two types, based on the sensor structures regarding analyte receptor and signal transducer. Type 1 sensors, with a single component for both receptor and transducer, work by mechanisms similar to those of 'molecular probes'. Type 2 sensors, with a separate component for receptor and transducer, work by different mechanisms that require the presence of specific NPs. A synergistic increase in optical signal or selectivity has been reported for these second type of NP sensors. With ongoing rapid advances in nanotechnology and instrumentation, these NP systems will soon be capable of sensing at the single-molecule level, at the point of interest within the living cell, and capable of simultaneously detecting multiple analytes and physical parameters.

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Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms

Cited by 23 publications

References 54 publications

Material requirements for bio-inspired sensing systems

Material requirements for bio-inspired sensing systems

Analytical Performance Issues

Optical nanoparticle sensors for quantitative intracellular imaging

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