Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility
Anna Zhukovskaya,
Zimmerman Christopher,
Lindsay Willmore
et al.
Abstract:Some individuals are susceptible to the experience of chronic stress and others are more resilient. While many brain regions implicated in learning are dysregulated after stress, little is known about whether and how neural teaching signals during stress differ between susceptible and resilient individuals. Here, we seek to determine if activity in the lateral habenula (LHb), which encodes a negative teaching signal, differs between stress susceptible and resilient mice during stress to produce different outco… Show more
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