Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake

Sanchez‐Roige, Sandra; Stephens, David; Duka, Theodora

doi:10.1111/acer.13184

Cited by 35 publications

(25 citation statements)

References 52 publications

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“…Our findings suggest that maladaptive impulsivity can be induced or can exacerbate an innate impulsivity trait. This is consistent with the evidence of development of disruptive impulsive behavioral changes in human subjects who had no maladaptive impulsivity prior to AUD …”

Section: Discussionsupporting

confidence: 91%

Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice

et al. 2019

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Waiting impulsivity is a risk factor for many psychiatric disorders including alcohol use disorder (AUD). Highly impulsive individuals are vulnerable to alcohol abuse. However, it is not well understood whether chronic alcohol use increases the propensity for impulsive behavior. Here, we establish a novel experimental paradigm demonstrating that continuous binge-like ethanol exposure progressively leads to maladaptive impulsive behavior. To test waiting impulsivity, we employed the 5-choice serial reaction time task (5-CSRTT) in C57BL/6J male mice. We assessed premature responses in the fixed and variable intertrial interval (ITI) 5-CSRTT sessions. We further characterized our ethanol-induced impulsive mice using Open Field, y-maze, two-bottle choice, and an action-outcome task. Our results indicate that continuous binge-like ethanol exposure significantly increased premature responses when mice were tested in variable ITI sessions even during a prolonged abstinent period. Ethanol-induced impulsive mice exhibited anxiety-like behavior during chronic exposures. This behavior was also observed in a separate cohort that was subjected to 20 days of abstinence. Ethanol-treated mice were less motivated for a sucrose reward compared with air-exposed control mice, while also demonstrating reduced responding during action-outcome testing. Overall, ethanol-treated mice demonstrated increased impulsive behavior, but a reduced motivation for a sucrose reward. Although waiting impulsivity has been hypothesized to be a trait or risk factor for AUD, our findings indicate that maladaptive impulse control can also be potentiated or induced by continuous chronic ethanol exposure in mice.

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Section: Discussionsupporting

confidence: 91%

Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice

et al. 2019

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“…One important risk mechanism, heightened behavioral impulsivity, has received particularly intensive study (Coskunpinar et al, 2013, Klein et al, 2016, Sanchez-Roige et al, 2016, Stephan et al, 2016, Wardell et al, 2016). Impulsivity can be characterized by questionnaire assessment or laboratory test.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study

Ide

Zhornitsky

et al. 2017

NeuroImage: Clinical

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Alcohol expectancy and impulsivity are implicated in alcohol misuse. However, how these two risk factors interact to determine problem drinking and whether men and women differ in these risk processes remain unclear. In 158 social drinkers (86 women) assessed for Alcohol Use Disorder Identification Test (AUDIT), positive alcohol expectancy, and Barratt impulsivity, we examined sex differences in these risk processes. Further, with structural brain imaging, we examined the neural bases underlying the relationship between these risk factors and problem drinking. The results of general linear modeling showed that alcohol expectancy best predicted problem drinking in women, whereas in men as well as in the combined group alcohol expectancy and impulsivity interacted to best predict problem drinking. Alcohol expectancy was associated with decreased gray matter volume (GMV) of the right posterior insula in women and the interaction of alcohol expectancy and impulsivity was associated with decreased GMV of the left thalamus in women and men combined and in men alone, albeit less significantly. These risk factors mediated the correlation between GMV and problem drinking. Conversely, models where GMV resulted from problem drinking were not supported. These new findings reveal distinct psychological factors that dispose men and women to problem drinking. Although mediation analyses did not determine a causal link, GMV reduction in the insula and thalamus may represent neural phenotype of these risk processes rather than the consequence of alcohol consumption in non-dependent social drinkers. The results add to the alcohol imaging literature which has largely focused on dependent individuals and help elucidate alterations in brain structures that may contribute to the transition from social to habitual drinking.

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“…Specifically, in a study examining delay discounting among mothers with and without nicotine dependence and their children (Reynolds et al, 2009) smoking mothers and their children had significantly higher rates of discounting compared to non-smoking mothers and their children, suggesting that delay discounting may function as a behavioral risk factor for adolescent cigarette smoking that precedes any significant nicotine use. However, in order to reach firm well-founded conclusions future work assessing the relationship between family history and discounting that aim to understand and explain reasons of inconsistency in findings from the current study and some previous ones of significant association (Dougherty et al, 2014; Smith et al, 2015; VanderBroek et al, 2016) compared to other findings of no association ( Herting et al, 2010; Sanchez-Roige et al, 2016) is needed. In addition, investigating other risk factors that might alter rates of discounting as a function of abstinence such as cessation duration, severity of addiction, and the presence of any ongoing secondary addictions and how they can affect the relationship between rates of discounting, having a family history of addiction and recovery might be beneficial.…”

Section: 0 Discussionmentioning

confidence: 89%

“…Few studies, however, have examined the association between delay discounting and family history of addiction. Those that have reported mixed results, with some reporting a positive association (Dougherty et al, 2014; Smith et al, 2015; VanderBroek et al, 2016), some reporting a positive association among women but not men (Petry et al, 2002) and some indicating no association (Herting et al, 2010; Sanchez-Roige et al, 2016). Importantly, these studies compared groups of participants with and without a family or parental history of addiction but did not investigate or report the effect of number of parents with addiction in the family on rates of discounting.…”

Section: 0 Introductionmentioning

confidence: 99%

The association between parental history and delay discounting among individuals in recovery from addiction

Stein

Quisenberry

Pope

et al. 2017

Drug and Alcohol Dependence

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Background Family history of addiction is a risk factor for substance use disorders. Delay discounting (DD) is associated with the risk of substance use and dependence, and is predictive of the likelihood of successful abstinence and treatment outcomes; thus, we investigated the extent to which having parents with addiction (parental history of addiction) and number of addicted parents affect DD among individuals in recovery from addiction. Methods Data from 177 individuals in recovery from addiction from The International Quit and Recovery Registry (IQRR), an ongoing online data collection program that aims to understand addiction and how people succeed in recovery, were included in the analysis. Participants with no, one, or two parents with addiction were compared on measures of DD using an adjusting-amount task. Results Parental history of addiction was significantly associated with delay discounting. After controlling for age and gender, which were significantly different between groups, participants reporting two biological parents with addiction had significantly higher DD rates compared to those reporting one or no parents with addiction. Conclusions Participants with two parents with addiction had significantly higher rates of discounting compared to those with no or only one parent with addiction. This information can serve as a foundation to better identify and target important subgroups that need additional or non-traditional intervention strategies to address their larger degree of impulsivity and help maintain abstinence or achieve better treatment outcomes.

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Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake

Cited by 35 publications

References 52 publications

Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice

Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study

The association between parental history and delay discounting among individuals in recovery from addiction

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