Heightened Heart Rate Response to Alcohol Intoxication Is Associated With a Reward‐Seeking Personality Profile

Brunelle, Caroline; Assaad, Jean-Marc; Barrett, Sean P.; Ávila, César; Conrod, Patricia J.; Tremblay, Richard E.; Pihl, Robert O.

doi:10.1097/01.alc.0000117859.23567.2e

Cited by 89 publications

(75 citation statements)

References 69 publications

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“…Recent studies suggest that risk for alcohol abuse is conveyed by a biologically based trait of reward sensitivity (Franken et al, 2006). Sensitivity to reward has been shown to be associated with a stronger physiological response to alcohol intake as well as an increase in conditioned responses to alcohol cues (Brunelle et al, 2004). In addition, early initiation of alcohol intake was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009), specifically in adolescence, since this period was characterized as a high risk period for first alcohol use and the transition to alcohol abuse and dependence (Wittchen et al, 2008;Swendsen et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Reward sensitivity is also associated with increased alcohol cue responding, heightened heart rate response to alcohol intoxication and higher alcohol craving (Franken et al, 2006), stronger physiological responses to alcohol and higher conditioning to alcohol cues (Brunelle et al, 2004). Early initiation of alcohol intake, even at very low levels of alcohol use, was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Nees

Tzschoppe

Patrick

et al. 2011

Neuropsychopharmacol

126

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Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N ¼ 324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Nees

Tzschoppe

Patrick

et al. 2011

Neuropsychopharmacol

126

View full text Add to dashboard Cite

show abstract

“…If the ML-DA deficiency is one predisposing factors in addiction vulnerability 23 , it is also true that sensitivity to the rewarding effects of drugs forms a key component (de Wit et al, 1986;O'Brien et al, 1996;Brunelle et al, 2004;Uhl, 2004). Therefore, it remains to be established why individuals with a blunted ML-DA transmission should present an enhanced ML-DA response to drugs and novelty.…”

Section: Individual Vulnerabilitymentioning

confidence: 99%

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Alcaro

Huber

Panksepp

2007

Brain Research Reviews

511

294

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The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning. The affective neuroethological perspective presented here, views the ML-DA system in terms of its ability to activate an instinctual emotional appetitive state (SEEKING) evolved to induce organisms to search for all varieties of life-supporting stimuli and to avoid harms.A description of the anatomical framework in which the ML system is embedded is followed by the argument that the SEEKING disposition emerges through functional integration of ventral basal ganglia (BG) into thalamocortical activities. Filtering cortical and limbic input that spread into BG, DA transmission promotes the "release" of neural activity patterns that induce active SEEKING behaviors when expressed at the motor level. Reverberation of these patterns constitutes a neurodynamic process for the inclusion of cognitive and perceptual representations within the extended networks of the SEEKING urge. In this way, the SEEKING disposition influences attention, incentive salience, associative learning, and anticipatory predictions.In our view, the rewarding properties of drugs of abuse are, in part, caused by the activation of the SEEKING disposition, ranging from appetitive drive to persistent craving depending on the intensity of the affect. The implications of such a view for understanding addiction are considered, with particular emphasis on factors predisposing individuals to develop compulsive drug seeking behaviors.

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“…For example, people vulnerable to alcoholism tend to show exaggerated reactions to alcohol use and have more positive feelings about this experience than normal people. In addition, characteristics like novelty-seeking and sensation-seeking are higher in this group of people (Brunelle et al, 2004). Given that these components were not examined in the present study, we suggest future studies to explore these factors, in order to achieve a more comprehensive understanding of this subject.…”

Section: Discussionmentioning

confidence: 77%

Emotion Regulation Problems and Addiction Potential in Iranian Students

Rahbarian

mohammadi

Abasi

et al. 2017

PCP

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Objective: Recent studies have shown that emotion dysregulation is one of the most significant factors in young people's tendency towards risky behaviors. Therefore, it seems necessary to study the role of emotion regulation strategies in drug-related behaviors. The goal of the present study was to examine the relationship between emotion regulation strategies, and addiction potential in the Iranian student population. Methods:In this cross sectional study, a convenient sampling method was used to select a total of 388 students from the universities in Tehran. The Difficulties in Emotion Regulation Scale (DERS) and Addiction Potential Scale (IAPS) were used to collect data. The study data were analyzed using the Pearson's correlation coefficient and hierarchical regression analysis.Results: According to the study results, limited access to emotion regulation strategies was the sole predictor of active addiction potential (t=2.79, P<0.01). Passive addiction potential was predicted by emotional awareness (t=4.89, P<0.001) and also by limited access to emotion regulation strategies (t=5.01, P<0.01). Conclusion:Emotion regulation strategies and emotional awareness in relation to other components of emotion regulation were found to have more association with addiction potential. It was also seen that emotion regulation strategies training was effective in the prevention of drug dependence.

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Heightened Heart Rate Response to Alcohol Intoxication Is Associated With a Reward‐Seeking Personality Profile

Abstract: Novelty/sensation-seeking is among the personality traits that have been linked to heavy alcohol use. This study suggests that reward sensitivity might mediate the relationship between this personality profile and drinking behavior.

Cited by 89 publications

References 69 publications

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Emotion Regulation Problems and Addiction Potential in Iranian Students

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