2008
DOI: 10.1152/ajpheart.00185.2008
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Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome

Abstract: Type II diabetes mellitus (DM) and metabolic syndrome are associated with accelerated restenosis following vascular interventions due to neointimal hyperplasia. The efficacy of nitric oxide (NO)-based therapies is unknown in these environments. Therefore, the aim of this study is to examine the efficacy of NO in preventing neointimal hyperplasia in animal models of type II DM and metabolic syndrome and examine possible mechanisms for differences in outcomes. Aortic vascular smooth muscle cells (VSMC) were harv… Show more

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Cited by 31 publications
(47 citation statements)
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“…The neck was shaved and prepped with betadine and alcohol (75%). Following a midline neck incision, the rat carotid artery balloon injury model was performed using a 2F Fogarty catheter (generously provided by Edwards Lifesciences), as previously described (2,24,36,39). After injury and restoration of blood flow, 10 mg of the diazeniumdiolate NO donor disodium 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) was applied evenly to the external surface of the injured common carotid artery of rats in the treatment group, and the neck incision was closed.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The neck was shaved and prepped with betadine and alcohol (75%). Following a midline neck incision, the rat carotid artery balloon injury model was performed using a 2F Fogarty catheter (generously provided by Edwards Lifesciences), as previously described (2,24,36,39). After injury and restoration of blood flow, 10 mg of the diazeniumdiolate NO donor disodium 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) was applied evenly to the external surface of the injured common carotid artery of rats in the treatment group, and the neck incision was closed.…”
Section: Methodsmentioning
confidence: 99%
“…Until recently, the efficacy of NO-based therapies in a diabetic environment was unknown. Our laboratory recently showed that NO was a more effective therapy for neointimal hyperplasia in animal models of insulin resistance (i.e., type 2 diabetes and metabolic syndrome) compared with control animals (2). But to our knowledge, the efficacy of NO-based therapies in insulin-deficient type 1 diabetes remains unknown.…”
mentioning
confidence: 99%
“…In obese Zucker rats, carotid artery balloon injury was associated with increased intimal thickness and increased VSMC proliferation (43). (43) Furthermore, increased intimal hyperplasia correlated with increased reactive oxygen species (ROS) production, as demonstrated by dihydroethidium staining (39). This study did not demonstrate enhanced cell proliferation in metabolic syndrome.…”
Section: Discussionmentioning
confidence: 75%
“…Abnormalities in the synthesis and metabolism of heparan sulfate have also been reported in association with both experimental and human diabetes (36)(37)(38). (20, 21)(22-26) (39,40) Metabolic syndrome is characterized by hyperinsulinemia due to insulin resistance at the cellular level, high glucose levels, a pro-inflammatory and a prothrombotic state (41). In this study, the intimal response after arterial injury of mice with metabolic syndrome was increased 6-fold over similar wild-type mice but had an increase in proteoglycan deposition equivalent to that seen in the diabetic mice and a lower cell proliferation response to that observed in wild-type mice.…”
Section: Discussionmentioning
confidence: 99%
“…63, 64 Intracellular hyperglycemia in type II diabetes mellitus activates protein kinase C, which leads to downregulation of endothelial NO synthase (eNOS) and upregulation of endothelin production, which antagonizes NO. Furthermore, hyperglycemia induces reactive oxygen species (ROS), which subsequently results in decreased prostacyclin synthase.…”
Section: Progression Of Coronary Artery Obstructive Diseasementioning
confidence: 99%