Heightened Amygdala Long-Term Potentiation in Neurotensin Receptor Type-1 Knockout Mice

Amano, Taiju; Wada, Etsuko; Yamada, Daisuke; Zushida, Ko; Maeno, Hiroshi; Нода, Мами; Wada, Keiji; Sekiguchi, Masayuki

doi:10.1038/npp.2008.38

Cited by 17 publications

(3 citation statements)

References 49 publications

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“…Indeed, photostimulation of LH neurotensin neuron terminals in the VTA robustly supported positive reinforcement (Kempadoo et al, 2013). In contrast, neurotensin has also been linked to fear conditioning (Amano et al, 2008). Neurotensin is thought to play a role in modulating glutamatergic transmission (Ferraro et al, 2008).…”

Section: Biological Substrates For Emotional Processingmentioning

confidence: 99%

Neural Circuit Motifs in Valence Processing

Tye

2018

Neuron

190

128

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How do our brains determine whether something is good or bad? How is this computational goal implemented in biological systems? Given the critical importance of valence processing for survival, the brain has evolved multiple strategies to solve this problem at different levels. The psychological concept of “emotional valence” is now beginning to find grounding in neuroscience. This review aims to bridge the gap between psychology and neuroscience on the topic of emotional valence processing. Here, I highlight a subset of studies that exemplify circuit motifs that repeatedly appear as implementational systems in valence processing. The motifs I identify as being important in valence processing include: 1) Labeled lines, 2) Divergent Paths, 3) Opposing Components, and 4) Neuromodulatory Gain. Importantly, the functionality of neural substrates in valence processing is dynamic, context-dependent, and changing across short and long time scales due to synaptic plasticity, competing mechanisms, and homeostatic need.

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Section: Biological Substrates For Emotional Processingmentioning

confidence: 99%

Neural Circuit Motifs in Valence Processing

Tye

2018

Neuron

190

128

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“…85,86 Both NTR 1 and NTR 2 are present on neurons in brain regions known to be associated with seizure activity, including basolateral amygdala and hippocampus. 87 There is still little known about how NT receptors mediate the anticonvulsant properties of NT.…”

Section: Nt Receptor Pharmacologymentioning

confidence: 99%

Anticonvulsant neuropeptides as drug leads for neurological diseases

Robertson¹,

Flynn²,

White³

et al. 2011

Nat. Prod. Rep.

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Anticonvulsant neuropeptides are best known for their ability to suppress seizures and modulate pain pathways. Galanin, neuropeptide Y, somatostatin, neurotensin, dynorphin, among others, have been validated as potential first-in-class anti-epileptic or/and analgesic compounds in animal models of epilepsy and pain, but their therapeutic potential extends to other neurological indications, including neurodegenerative and psychatric disorders. Disease-modifying properties of neuropeptides make them even more attractive templates for developing new-generation neurotherapeutics. Arguably, efforts to transform this class of neuropeptides into drugs have been limited compared to those for other bioactive peptides. Key challenges in developing neuropeptide-based anticonvulsants are: to engineer optimal receptor-subtype selectivity, to improve metabolic stability and to enhance their bioavailability, including penetration across the blood–brain barrier (BBB). Here, we summarize advances toward developing systemically active and CNS-penetrant neuropeptide analogs. Two main objectives of this review are: (1) to provide an overview of structural and pharmacological properties for selected anticonvulsant neuropeptides and their analogs and (2) to encourage broader efforts to convert these endogenous natural products into drug leads for pain, epilepsy and other neurological diseases.

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“…Because patch‐clamp recordings in marmoset brain slices have not previously been reported, we here describe our method in detail. Brain slice preparation and patch‐clamp recordings were performed as reported previously (Zushida et al 2007; Amano et al 2008; Sekiguchi et al 2009), with minor modifications. Marmosets were anaesthetized with ketamine and administered an overdose of pentobarbital.…”

Section: Methodsmentioning

confidence: 99%

Adult‐like action potential properties and abundant GABAergic synaptic responses in amygdala neurons from newborn marmosets

Yamada

Miyajima

Ishibashi

et al. 2012

The Journal of Physiology

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Key points• The amygdala plays an important role in the processing of emotional events, but little is known about the postnatal development of electrophysiological properties of amygdala neurons.• We performed slice patch-clamp recordings from basolateral amygdala (BLA) pyramidal neurons in the developing and adult common marmoset (Callithrix jacchus).• The marmoset is a non-human primate that has been increasingly used as an animal model of human disease, but no previous studies have used brain slice patch-clamp techniques in marmosets.• We found that BLA pyramidal neurons from newborn marmosets possess relatively mature action potentials and receive vigorous GABAergic synaptic inputs, and that marmoset BLA neurons acquire adult-like electrophysiological properties within the first 4 weeks of life.• Our study provides novel information on several features of postnatal development of BLA pyramidal neurons in marmosets.Abstract The amygdala plays an important role in the processing of emotional events. This information processing is altered by development, but little is known about the development of electrophysiological properties of neurons in the amygdala. We studied the postnatal development of electrophysiological properties of neurons in the basolateral amygdala (BLA) of the common marmoset (Callithrix jacchus). Whole-cell patch-clamp recordings were obtained from BLA pyramidal neurons in brain slices prepared from developing and adult marmosets, and electrophysiological properties known to change during development in rats were analysed. Two passive electrical properties of the neuronal membrane -the input resistance (R in ) and the membrane time constant (τ) -significantly decreased with postnatal development. In contrast, the action potential only showed a slight decrease in duration during the first month of life, whereas the amplitude did not change after birth. Passive electrical properties and action potentials in neurons of 4-week-old marmosets were similar to those in neurons of 4-year-old marmosets. The development of the action potential duration was not correlated with the development of R in or τ, whereas the development of R in and τ was correlated with each other. Abundant spontaneous and noradrenaline-induced GABAergic currents were present immediately after birth and did not change during postnatal development. These results suggest that newborn infant marmoset BLA pyramidal neurons possess relatively mature action potentials and receive vigorous GABAergic

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Heightened Amygdala Long-Term Potentiation in Neurotensin Receptor Type-1 Knockout Mice

Cited by 17 publications

References 49 publications

Neural Circuit Motifs in Valence Processing

Neural Circuit Motifs in Valence Processing

Anticonvulsant neuropeptides as drug leads for neurological diseases

Adult‐like action potential properties and abundant GABAergic synaptic responses in amygdala neurons from newborn marmosets

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