Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor

Dhakar, Monica B.; Rich, Megan Elizabeth; Reno, Emily L.; Lee, Heon-Jin; Caldwell, Heather K.

doi:10.1016/j.yhbeh.2012.05.007

Cited by 49 publications

(38 citation statements)

References 53 publications

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“…Additionally, [23] indicated that affiliative behaviors might induce hypothalamic OT expression, which in turn may attenuate stress responses in delayed gastric emptying and accelerated colonic transit. These results are supported by those of Dhakar et al [24], who showed that OT-receptor knockout rats performed exhibited aggressive behavior than intact animals. Further, centrally administered OT also induced grooming behavior in male rats [25], affiliative response of huddled sitting in the subordinate squirrel monkey [26], and flexible behaviors such as locomotors activity in the open field under stress condition [27].…”

Section: Roles Of Oxytocin On Animal Welfaresupporting

confidence: 84%

Role of oxytocin in improving the welfare of farm animals — A review

Chen

Sato

2016

Asian-Australas J Anim Sci

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Recently, increasing attention has been paid to the welfare of farm animals, which have been evaluated using behavioral and physiological measures. However, so far, the measures have almost always been used to estimate poor welfare. In this review, firstly we focus on how oxytocin (OT) relates to positive social behavior, pleasure, and stress tolerance, and second on which management factors stimulate OT release. OT induces maternal and affiliative behaviors and has an anti-stress effect. Further, OT is produced during enjoyable events, and has positive feedback on its own release as well. Therefore, to some extent, the relationship of OT to positive normal behavior was mutually beneficial—heightened OT concentration owing to comfortable rearing conditions induces positive social behavior, which in turn may increase OT concentration. Hence, studies on animal welfare should pay more attention to increasing comfort and the stress tolerance, rather than only focusing on when stress occurs in farm animals.

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Section: Roles Of Oxytocin On Animal Welfaresupporting

confidence: 84%

Role of oxytocin in improving the welfare of farm animals — A review

Chen

Sato

2016

Asian-Australas J Anim Sci

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“…On the other hand, it was previously shown that OTR-knockout male mice displayed heightened aggressive behaviors toward both C57BL/6J and BALB/c male intruders (Dhakar et al, 2012;Takayanagi et al, 2005). We can only speculate on the reason for this discrepancy, but differences in the residents' state may be a contributing factor.…”

Section: Discussionmentioning

confidence: 73%

Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice

Hattori

Kanno

Nagasawa

et al. 2015

Neuroscience Research

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“…Due in part to the low levels of aggressive behaviors displayed by Avpr1b −/− mice we examined intruder-evoked, not aggression-evoked, IEG activation. Though, previous work suggests that exposure to the context alone, in the absence of a physical encounter, is sufficient to result in neural activation in brain areas that are known to be important to aggressive behaviors [17, 34]. …”

Section: Discussionmentioning

confidence: 99%

“…Following isolation, the procedure for both tests was the same. Group-housed male Balb/c mice, a strain we have previously used as stimulus animals [21, 34], between the ages of 2 and 5 months were purchased from Jackson Laboratories (Bar Harbor, ME) and used as intruder animals. In order to acclimate both intruder and experimental animals to the testing space, all animals were moved to the behavioral testing room at least 1 h prior to testing and left undisturbed.…”

Section: Methodsmentioning

confidence: 99%

“…Using Power Block™ Universal Blocking Reagent (BioGenex, San Ramon, CA), the tissue was blocked for 30 min. One of the two series was then incubated overnight in rabbit anti-c-FOS primary antibody (Santa Cruz Biochemicals, Santa Cruz, CA, USA, sc-52) at a dilution of 1:5000 in antisera diluent (1XPBS + 1% normal goat serum + 0.3% Triton X-100) at 4 °C [34]. The second set of tissue was incubated for 2 days in rabbit anti-EGR-1 primary antibody (Santa Cruz Biochemicals, Santa Cruz, CA, USA, sc-189) at a dilution of 1:10,000 in antisera diluent (same as described above) at 4 °C.…”

Section: Methodsmentioning

confidence: 99%

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Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice

2016

Self Cite

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BackgroundThe neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal aggressive behaviors and social recognition memory. However, this brain area is just one part of a larger neural circuit that is likely to be impacted in Avpr1b knockout (−/−) mice. To identify other brain areas that are affected by altered Avpr1b signaling, genotypic differences in immediate early gene activation, i.e. c-FOS and early growth response factor 1 (EGR-1), were quantified using immunocytochemistry following a single exposure to an intruder.ResultsIn females, no genotypic differences in intruder-evoked c-FOS or EGR-1 immunoreactivity were observed in any of the brain areas measured. In males, while there were no intruder-evoked genotypic differences in c-FOS immunoreactivity, genotypic differences were observed in EGR-1 immunoreactivity within the ventral bed nucleus of the stria terminalis and the anterior hypothalamus; with Avpr1b −/− males having less EGR-1 immunoreactivity in these regions than controls.ConclusionsThese data are the first to identify specific brain areas that may be a part of a neural circuit that includes Avpr1b-expressing cells in the CA2 region of the hippocampus. It is thought that this circuit, when working properly, plays a role in how an animal evaluates its social context.Electronic supplementary materialThe online version of this article (doi:10.1186/s12868-016-0310-7) contains supplementary material, which is available to authorized users.

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Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor

Cited by 49 publications

References 53 publications

Role of oxytocin in improving the welfare of farm animals — A review

Role of oxytocin in improving the welfare of farm animals — A review

Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice

Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice

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