Height Attainment in Children With Steroid-Responsive Nephrotic Syndrome

Foote, Kelly D.; Brocklebank, J T; Meadow, S R

doi:10.1016/s0140-6736(85)90851-7

Cited by 58 publications

(39 citation statements)

References 7 publications

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“…Berns et al [16] showed that the response to cyclophosphamide was strongly dependent on histologic lesions, while Webb et al [21] stressed that response to cytotoxic therapy was better correlated with initial steroid sensitivity than histology. The natural history of SRNS is for relapses to become less frequent with age [21,22]. Kabuki et al [23] showed that children under 4 years at onset age were at high risk for subsequent frequently relapsing disease compared with those with older onset of SRNS.…”

Section: Discussionmentioning

confidence: 99%

“…We could not confirm the observation of Genova et al [26] that males with SRNS exhibit better growth than females. Foote et al [22] analyzed the correlation between the total dose of prednisolone applied per square meter and final height in patients with SRNS. Since we did not calculate the prednisolone dose, we could not assess any correlation between total doses of corticosteroids and ultimate adult height.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

Matsukura

Inaba²,

Shinozaki³

et al. 2001

Am J Nephrol

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Eighty-six patients (59 males and 27 females) diagnosed with steroid-responsive nephrotic syndrome during childhood were identified. The patients were 20–40 years of age (mean 27.0 ± 5.0) with a mean follow-up period of 19.5 ± 5.9 years. All patients had been treated with a long-term tapering corticosteroid therapy. Thirty patients had also received a course of cyclophosphamide (2 mg/kg/day for 12 weeks). Sixty-six had achieved sustained remission off corticosteroids, while 20 were still receiving corticosteroids to maintain remission. None of the 86 patients had proteinuria or renal insufficiency at the time of the study. Mean final heights in males and females were similar (–0.51 ± 1.21 and –0.23 ± 1.16 standard deviation score). Mean final height of 20 steroid-dependent patients was significantly less than that of 66 in remission off corticosteroids (p < 0.005). Ten cyclophosphamide-treated patients got married and 9 had at least 1 healthy child. In children with steroid-responsive nephrotic syndrome, the need for corticosteroid therapy to maintain remission may be associated with decreased adult height. Patients who received a 12-week course of cyclophosphamide are likely to be normally fertile as adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

Matsukura

Inaba²,

Shinozaki³

et al. 2001

Am J Nephrol

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“…In children, daily treatment with corticosteroids inhibits growth in a dose-dependent fashion when used for a prolonged period of time (1)(2)(3). Growth inhibition by corticosteroids has also been demonstrated in rats (4)(5)(6).…”

Section: Introductionmentioning

confidence: 98%

Effect of the synthetic glucocorticoid, deflazacort, on body growth, pulsatile secretion of GH and thymolysis in the rat

Latta

Krieg

Hisano

et al. 1999

European Journal of Endocrinology

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Design: Deflazacort (DFZ) is a relatively new glucocorticoid that has been reported to exhibit fewer sideeffects than other commonly used corticosteroids. The present study was designed to test the effects of DFZ on thymus gland involution (thymolysis), as compared with body growth and the secretory pattern of GH in the rat. Beginning at 38 days of age, male animals were treated for 8 consecutive days by s.c. injection of DFZ (0.15 mg/day), cortisone (CORT) (5 mg/day) or vehicle (control, CTRL). Results: Both glucocorticoids had a similar thymolytic effect and caused growth failure, but the growth rate for the DFZ group was significantly higher than that of the CORT group. On day 46, pulsatile GH secretion was quantitated by blood sampling via an indwelling catheter at 10 min intervals for 6 h. GH was assayed by RIA and analyzed by multiparameter deconvolution. CORT caused an increase in pulse frequency (5.8 Ϯ 0.4 (S.E.M.)) in comparison to DFZ (4.4 Ϯ 0.4) and CTRL (3.8 Ϯ 0.3). Both glucocorticoids significantly shortened the interval between secretory bursts. In CTRL animals the interval between bursts was 69.3 Ϯ 4.5 min. In DFZ animals this was reduced to 58.5 Ϯ 7.1 min, and in CORT rats it was further reduced to 47.0 Ϯ 2.6 min. The mass of GH secreted per burst was reduced in CORT animals (52% of CTRL), while DFZ did not alter this parameter. A similar trend was observed for total GH production, with CORT causing a reduction and DFZ not affecting the secretion. Conclusion: Rats treated with glucocorticoid show a profound thymolytic effect, as well as important changes in growth. While CORT suppresses GH secretion and alters its pulsatile mode of release, DFZ causes a less significant alteration in the pattern of GH secretion and does not negatively affect the overall amount of GH secreted.

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“…However, when corticosteroid therapy was extended to 18 months, an ultimate loss in height percentiles was observed (3). On the other hand, in long-term studies where children were treated with intermittent courses of corticosteroids as well as alternate day regimens, no effect on ultimate height attainment was noted generally (4,5).…”

mentioning

confidence: 99%

Can Growth Hormone Treatment Improve the Growth Retardation in Children Associated with Steroid Dependent Nephrotic Syndrome

Yap

Loke

Lee

1997

Clin Pediatr Endocrinol

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Height Attainment in Children With Steroid-Responsive Nephrotic Syndrome

Cited by 58 publications

References 7 publications

Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

Effect of the synthetic glucocorticoid, deflazacort, on body growth, pulsatile secretion of GH and thymolysis in the rat

Can Growth Hormone Treatment Improve the Growth Retardation in Children Associated with Steroid Dependent Nephrotic Syndrome

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