Heidenhain Pouch Secretory Response as Affected by Gastrojejunostomy to the Main Stomach.

Schmitz, Evan; Kanar, Edmund A.; Storer, Edward H.; Sauvage, Lester R.; Harkins, Henry N.

doi:10.3181/00379727-81-19813

Cited by 12 publications

(1 citation statement)

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“…Reflux of duodenal contents has been known for many years to cause increased basal acid secretion [5] and recently has been shown to increase the acid response to pentagastrin [4] and the gastrin response to a meal [6], However, this hypersecretion did not occur when bile alone was instilled into the stomach via a cholecystogastrostomy. This finding is of interest, as Sokolov [7] showed in 1904 that bile instilled into the canine stomach evoked acid secretion from a Pavlov pouch.…”

Section: Discussionmentioning

confidence: 99%

Gastric Morphological and Functional Changes Produced by Bile in the Canine Stomach

Thomas¹

1981

Eur Surg Res

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Bile diverted into the canine stomach produced histological changes in gastric mucosa of mucus depletion, focal loss of epithelial cell height and focal epithelial degeneration that were maximal around the stoma. Bile depressed the gastric acid secretory response to both pentagastrin and histamine, but produced no change in fasting serum gastrin levels. The preparation used (cholecystogastrostomy) caused an elevation of both alkaline phosphatase and serum glutamic pyruvic transaminase.

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Section: Discussionmentioning

confidence: 99%

Gastric Morphological and Functional Changes Produced by Bile in the Canine Stomach

Thomas¹

1981

Eur Surg Res

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The Antrum

Chapman¹

1960

Arch Surg

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Effect of truncal vagotomy on functional and morphological changes produced by duodenogastric reflux

Thomas

1982

Digest Dis Sci

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The effects of truncal vagotomy on the functional and morphological changes produced by duodenogastric reflux have been studied in the dog. Duodenogastric reflux caused progressive damage to gastric mucosa, hypersecretion of acid to pentagastrin, and a hypergastrinemic response to a standard meal. Truncal vagotomy barely altered the mucosal changes produced by reflux, but it did prevent antral gland hyperplasia and reduced the acid and gastrin secretory responses. These findings are clinically reassuring in that vagotomy effectively prevented the hypersecretory state produced by duodenogastric reflux.

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Heidenhain Pouch Secretory Response as Affected by Gastrojejunostomy to the Main Stomach.

Cited by 12 publications

References 0 publications

Gastric Morphological and Functional Changes Produced by Bile in the Canine Stomach

Gastric Morphological and Functional Changes Produced by Bile in the Canine Stomach

The Antrum

Effect of truncal vagotomy on functional and morphological changes produced by duodenogastric reflux

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