Hedgehog signaling regulates dental papilla formation and tooth size during zebrafish odontogenesis

Yu, J.; Fox, Zachary D.; Crimp, James L.; Littleford, Hana E.; Jowdry, Andrea L.; Jackman, William R.

doi:10.1002/dvdy.24258

Cited by 16 publications

(14 citation statements)

References 53 publications

(75 reference statements)

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“…It has also been demonstrated that crown size depends on the contact area between the Shh-expressing inner enamel epithelium and the dental mesenchyme [54]. These findings indicate that Shh signaling may regulate cellular proliferation in the dental mesenchyme, thereby controlling tooth morphogenesis [38,41,58].…”

Section: Shh Signaling Functions In the Dental Mesenchyme And Is Invomentioning

confidence: 90%

Sonic Hedgehog Signaling and Tooth Development

Hosoya

Shalehin

Takebe

et al. 2020

IJMS

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Sonic hedgehog (Shh) is a secreted protein with important roles in mammalian embryogenesis. During tooth development, Shh is primarily expressed in the dental epithelium, from initiation to the root formation stages. A number of studies have analyzed the function of Shh signaling at different stages of tooth development and have revealed that Shh signaling regulates the formation of various tooth components, including enamel, dentin, cementum, and other soft tissues. In addition, dental mesenchymal cells positive for Gli1, a downstream transcription factor of Shh signaling, have been found to have stem cell properties, including multipotency and the ability to self-renew. Indeed, Gli1-positive cells in mature teeth appear to contribute to the regeneration of dental pulp and periodontal tissues. In this review, we provide an overview of recent advances related to the role of Shh signaling in tooth development, as well as the contribution of this pathway to tooth homeostasis and regeneration.

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Section: Shh Signaling Functions In the Dental Mesenchyme And Is Invomentioning

confidence: 90%

Sonic Hedgehog Signaling and Tooth Development

Hosoya

Shalehin

Takebe

et al. 2020

IJMS

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“… Note : (−), no expression; (+), expression; †, conflicting expression data; (1), Holland et al ., 1987; (2), Lukinmaa et al ., 1993; (3), Vainio et al ., 1993; (4), Robinson & Mahon, 1994; (5), Bitgood & McMahon, 1995; (6), Mitsiadis et al ., 1995a; (7), Mitsiadis et al ., 1995b; (8), Vaahtokari et al ., 1996; (9), Åberg et al ., 1997; (10), Neubüser et al ., 1997; (11), Hardcastle et al ., 1998; (12), Jernvall et al ., 1998; (13), Keränen et al ., 1998; (14), Kettunen et al ., 1998; (15), Kettunen & Thesleff, 1998; (16), Kettunen et al ., 2000; (17), St. Amand et al ., 2000; (18), Tucker et al ., 2000; (19), Zhao et al ., 2000; (20), Laurikkala et al ., 2001; (21), Åberg et al ., 2004; (22), Fraser et al ., 2004; (23), Jackman et al ., 2004; (24), Borday‐Birraux et al ., 2006; (25), Fraser et al ., 2006a; (26), Fraser et al ., 2006b; (27), Wise & Stock, 2006; (28), Debiais‐Thibaud et al ., 2007; (29), Debiais‐Thibaud et al ., 2008; (30), Fraser et al ., 2008; (31), Jackman et al ., 2010; (32), Fraser et al ., 2013; (33), Yu et al ., 2015.…”

Section: Methodological Limitation Linked To Developmental Staging Inmentioning

confidence: 99%

Evolutionary developmental genetics of teeth and odontodes in jawed vertebrates: a perspective from the study of elasmobranchs

Berio

Debiais-Thibaud

2020

Journal of Fish Biology

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Most extant vertebrates display a high variety of tooth and tooth‐like organs (odontodes) that vary in shape, position over the body and nature of composing tissues. The development of these structures is known to involve similar genetic cascades and teeth and odontodes are believed to share a common evolutionary history. Gene expression patterns have previously been compared between mammalian and teleost tooth development but we highlight how the comparative framework was not always properly defined to deal with different tooth types or tooth developmental stages. Larger‐scale comparative analyses also included cartilaginous fishes: sharks display oral teeth and dermal scales for which the gene expression during development started to be investigated in the small‐spotted catshark Scyliorhinus canicula during the past decade. We report several descriptive approaches to analyse the embryonic tooth and caudal scale gene expressions in S. canicula. We compare these expressions wih the ones reported in mouse molars and teleost oral and pharyngeal teeth and highlight contributions and biases that arise from these interspecific comparisons. We finally discuss the evolutionary processes that can explain the observed intra and interspecific similarities and divergences in the genetic cascades involved in tooth and odontode development in jawed vertebrates.

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“…(c) Green fluorescent protein fluorescence and alizarin red S staining Amplification of GFP fluorescence with immunohistochemistry and alizarin red S staining of mineralized teeth was performed as in Yu et al [41]. To combine the two visualization methods in a single specimen, alizarin staining was done subsequent to the antibody label.…”

Section: (B) Zebrafish Assaysmentioning

confidence: 99%

The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish

Gibert¹,

Samarut

Ellis³

et al. 2019

Proc. R. Soc. B.

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The diversity of teeth patterns in actinopterygians is impressive with tooth rows in many locations in the oral and pharyngeal regions. The first-formed tooth has been hypothesized to serve as an initiator controlling the formation of the subsequent teeth. In zebrafish, the existence of the first tooth (named 4 V 1 ) is puzzling as its replacement is induced before the opening of the mouth. Functionally, it has been shown that 4 V 1 formation requires fibroblast growth factor (FGF) and retinoic acid (RA) signalling. Here, we show that the ablation of 4 V 1 prevents the development of the dental row demonstrating its dependency over it. If endogenous levels of FGF and RA are restored after 4 V 1 ablation, embryonic dentition starts again by de novo formation of a first tooth, followed by the dental row. Similarly, induction of anterior ectopic teeth induces subsequent tooth formation, demonstrating that the initiator tooth is necessary and sufficient for dental row formation, probably via FGF ligands released by 4 V 1 to induce the formation of subsequent teeth. Our results show that by modifying the formation of the initiator tooth it is possible to control the formation of a dental row. This could help to explain the diversity of tooth patterns observed in actinopterygians and more broadly, how diverse traits evolved through molecular fine-tuning.

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Hedgehog signaling regulates dental papilla formation and tooth size during zebrafish odontogenesis

Cited by 16 publications

References 53 publications

Sonic Hedgehog Signaling and Tooth Development

Sonic Hedgehog Signaling and Tooth Development

Evolutionary developmental genetics of teeth and odontodes in jawed vertebrates: a perspective from the study of elasmobranchs

The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish

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