Hedgehog signaling promotes TH2 differentiation in naive human CD4 T cells

Yánez, Diana C.; Lau, Ching‐In; Chawda, Mira Manilal; Ross, Scott R.; Furmanski, Anna L.; Crompton, Tessa

doi:10.1016/j.jaci.2019.07.011

Cited by 21 publications

(22 citation statements)

References 9 publications

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“…A third possibility is that the IFITM proteins are involved in enhancing or regulating the transduction of other signalling pathways that regulate Th differentiation. In support of this, they are transcriptional targets of Wnt and Hh signalling, and both these pathways promote Th2 differentiation …”

Section: The Ifitm Proteins In Adaptive Immunitymentioning

confidence: 86%

“…70,71 Given the link between IFITM and Hh signalling and the fact that Hh signalling has also been shown to promote Th2 differentiation and exacerbate allergic asthma, it will be important to investigate the interactions between IFITM proteins and the Hh pathway in allergic asthma. 11,[72][73][74][75][76][77] The IFITM proteins are associated with other atopic and inflammatory diseases. In atopic dermatitis patients, IFITM1-3 are up-regulated in lesional skin compared with non-lesional skin from the same individuals, although the functional consequences of their increased expression have not been investigated.…”

Section: The Ifitm Family In Allergic and Inflammatory Diseasementioning

confidence: 99%

“…In support of this, they are transcriptional targets of Wnt and Hh signalling, 10,11 and both these pathways promote Th2 differentiation. 72,74,85,86 Finally, it is possible that the IFITM proteins have unknown direct consequences for Th differentiation through an influence on transcription or translation (as has been described for some viral genes).…”

Section: Mechanisms Of Action Of Ifitm Proteins In Immune Cellsmentioning

confidence: 99%

“…The role of IFITM proteins in human allergic asthma has to our knowledge not been investigated, but genome‐wide association studies have linked IFITM2 and/or IFITM3 variants to potentially relevant traits, such as the proportion or count of basophils and eosinophils in blood, and lung function . Given the link between IFITM and Hh signalling and the fact that Hh signalling has also been shown to promote Th2 differentiation and exacerbate allergic asthma, it will be important to investigate the interactions between IFITM proteins and the Hh pathway in allergic asthma …”

Section: The Ifitm Proteins In Adaptive Immunitymentioning

confidence: 99%

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The IFITM protein family in adaptive immunity

2019

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Summary Interferon‐inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1–IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1–3, IFITM6). IFITM1–3 are expressed by T cells and recent experiments have shown that the IFITM proteins are directly involved in adaptive immunity and that they regulate CD4+ T helper cell differentiation in a T‐cell‐intrinsic manner. Here we review the role of the IFITM proteins in T‐cell differentiation and function.

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Section: The Ifitm Proteins In Adaptive Immunitymentioning

confidence: 86%

Section: The Ifitm Family In Allergic and Inflammatory Diseasementioning

confidence: 99%

Section: Mechanisms Of Action Of Ifitm Proteins In Immune Cellsmentioning

confidence: 99%

Section: The Ifitm Proteins In Adaptive Immunitymentioning

confidence: 99%

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The IFITM protein family in adaptive immunity

2019

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“…Moreover, involvement of the HH effector protein GLI2 in T-cell polarization and CD4+ cell differentiation in immunosuppressive T-regs has been demonstrated [37,107,108]. Interestingly, the experimental data on gastric cancer showed that GLI2 can drive the overexpression of PD-L1; the use of anti-PD-L1 antibodies in this context triggered the apoptosis of tumor cells [109].…”

Section: Hedgehog Pathway Inhibitorsmentioning

confidence: 99%

Can the New and Old Drugs Exert an Immunomodulatory Effect in Acute Myeloid Leukemia?

Tarantini

Cumbo

Anelli

et al. 2021

Cancers

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Acute myeloid leukemia (AML) is considered an immune-suppressive neoplasm capable of evading immune surveillance through cellular and environmental players. Increasing knowledge of the immune system (IS) status at diagnosis seems to suggest ever more attention of the crosstalk between the leukemic clone and its immunologic counterpart. During the last years, the advent of novel immunotherapeutic strategies has revealed the importance of immune dysregulation and suppression for leukemia fitness. Considering all these premises, we reviewed the “off-target” effects on the IS of different drugs used in the treatment of AML, focusing on the main advantages of this interaction. The data reported support the idea that a successful therapeutic strategy should consider tailored approaches for performing leukemia eradication by both direct blasts killing and the engagement of the IS.

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