Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad
Girish Deshpande,
Chris Ng,
Nicholas Jourjine
et al.
Abstract:In addition to inducing non-autonomous specification of cell fate in both Drosophila and vertebrates, the Hedgehog pathway guides cell migration in a variety of different tissues. Although its role in axon guidance in the vertebrate nervous system is widely recognized, its role guiding the migratory path of primordial germ cells (PGCs) from the outside surface of the Drosophila embryo through the midgut and mesoderm to the SGPs (somatic gonadal precursors) has been controversial. Here we present new experiment… Show more
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