Cell Reports volume 3, issue 5, P1407-1413 2013 DOI: 10.1016/j.celrep.2013.04.003 View full text
Dmitrij Ljaschenko, Nadine Ehmann, Robert J. Kittel

Abstract: Synaptic plasticity shapes the development of functional neural circuits and provides a basis for cellular models of learning and memory. Hebbian plasticity describes an activity-dependent change in synaptic strength that is input-specific and depends on correlated pre- and postsynaptic activity. Although it is recognized that synaptic activity and synapse development are intimately linked, our mechanistic understanding of the coupling is far from complete. Using Channelrhodopsin-2 to evoke activity in vivo, w…

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