Hebbian modification of a hippocampal population pattern in the rat

King, Charles; Henze, Darrell A.; Leinekugel, Xavier; Buzsáki, György

doi:10.1111/j.1469-7793.1999.00159.x

Cited by 114 publications

(101 citation statements)

References 37 publications

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“…Because SPW is a punctuate event whereas the sleep spindle is temporally protracted, the hippocampal output can be directed to the still active neocortical assemblies. The temporal coordination of these events facilitates conditions in which unique neocortical inputs to the hippocampus and, in turn, hippocampal outputs to the neocortex might be modified selectively (King et al, 1999;Sirota et al, 2003;Steriade and Timofeev, 2003). In this reciprocal information-transfer process, the neocortex serves as the target ('receiver') of the information from the 'source' (sender) hippocampus.…”

Section: Functional Implications Of the Periodic 'Rebooting' Of Neocomentioning

confidence: 99%

Interaction between neocortical and hippocampal networks via slow oscillations

Sirota

Buzsáki

2005

THL

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230

219

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Both the thalamocortical and limbic systems generate a variety of brain state-dependent rhythms but the relationship between the oscillatory families is not well understood. Transfer of information across structures can be controlled by the offset oscillations. We suggest that slow oscillation of the neocortex, which was discovered by Mircea Steriade, temporally coordinates the self-organized oscillations in the neocortex, entorhinal cortex, subiculum and hippocampus. Transient coupling between rhythms can guide bidirectional information transfer among these structures and might serve to consolidate memory traces.

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Section: Functional Implications Of the Periodic 'Rebooting' Of Neocomentioning

confidence: 99%

Interaction between neocortical and hippocampal networks via slow oscillations

Sirota

Buzsáki

2005

THL

Self Cite

230

219

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“…Disruption of ripple sequences during SWS interferes with memory consolidation [81]. It is important to note that neuronal activity during ripples is capable of inducing LTP at CA1 synapses [82], and therefore a similar network reorganization and information channelling as the one described in our fMRI-LTP experiments [49] may also help to explain the information transfer from the rstb.royalsocietypublishing.org Phil. Trans.…”

Section: (D) Considerations On the Origin Of Fmri Signalsmentioning

confidence: 99%

Functional MRI of long-term potentiation: imaging network plasticity

Álvarez-Salvado

Pallarés

Moreno

et al. 2014

Phil. Trans. R. Soc. B

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Neurons are able to express long-lasting and activity-dependent modulations of their synapses. This plastic property supports memory and conveys an extraordinary adaptive value, because it allows an individual to learn from, and respond to, changes in the environment. Molecular and physiological changes at the cellular level as well as network interactions are required in order to encode a pattern of synaptic activity into a longterm memory. While the cellular mechanisms linking synaptic plasticity to memory have been intensively studied, those regulating network interactions have received less attention. Combining high-resolution fMRI and in vivo electrophysiology in rats, we have previously reported a functional remodelling of long-range hippocampal networks induced by long-term potentiation (LTP) of synaptic plasticity in the perforant pathway. Here, we present new results demonstrating an increased bilateral coupling in the hippocampus specifically supported by the mossy cell commissural/ associational pathway in response to LTP. This fMRI-measured increase in bilateral connectivity is accompanied by potentiation of the corresponding polysynaptically evoked commissural potential in the contralateral dentate gyrus and depression of the inactive convergent commissural pathway to the ipsilateral dentate. We review these and previous findings in the broader context of memory consolidation.

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“…Sharp waves are associated with synchronous population bursts of CA3 pyramidal neurons and may be propagated via the extensive recurrent collateral system in CA3 (Buzsaki 1986;Suzuki and Smith 1988). SPW activity has been linked to neural plasticity in vivo (King et al 1999) and is hypothesized to be essential for memory formation (Buzsaki 1989). It would thus be advantageous to devise a means for generating SPWs in the hippocampal slice preparation such that hypotheses regarding their origins and potential functions could be more readily tested.…”

Section: Introductionmentioning

confidence: 99%

Endogenous Waves in Hippocampal Slices

Kubota¹,

Colgin²,

Casale

et al. 2003

Journal of Neurophysiology

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. Sharp waves (SPWs) are thought to play a major role in intrinsic hippocampal operations during states in which subcortical and cortical inputs to hippocampus are reduced. This study describes evidence that such activity occurs spontaneously in appropriately prepared rat hippocampal slices. Irregular waves, with an average frequency of approximately 4 Hz, were recorded from field CA3 in slices prepared from the temporal region of hippocampus. The waves persisted for hours and were not accompanied by aberrant discharges. Multi-electrode analyses established that they were locally generated within each of the subfields of CA3 and yet were coherent between subfields. The sharp waves were reversibly blocked by either cholinergic or serotonergic stimulation. Various lines of evidence indicate that they are propagated by the CA3 associational system.

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Hebbian modification of a hippocampal population pattern in the rat

Cited by 114 publications

References 37 publications

Interaction between neocortical and hippocampal networks via slow oscillations

Interaction between neocortical and hippocampal networks via slow oscillations

Functional MRI of long-term potentiation: imaging network plasticity

Endogenous Waves in Hippocampal Slices

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