We demonstrate a method for calculating the neutral B-meson decay constants and mixing matrix elements in unquenched lattice QCD with domain-wall light quarks and static b-quarks. Our computation is performed on the ''2 þ 1'' flavor gauge configurations generated by the RBC and UKQCD Collaborations with a lattice spacing of a % 0:11 fm (a À1 ¼ 1:729 GeV) and a lattice spatial volume of approximately ð1:8 fmÞ 3 . We simulate at three different light sea quark masses with pion masses down to approximately 430 MeV, and extrapolate to the physical quark masses using a phenomenologicallymotivated fit function based on next-to-leading order heavy-light meson SU(2) chiral perturbation theory. For the b-quarks, we use an improved formulation of the Eichten-Hill action with static link-smearing to increase the signal-to-noise ratio. We also improve the heavy-light axial current used to compute the B-meson decay constant to Oð s paÞ using one-loop lattice perturbation theory. We present initial results for the SU(3)-breaking ratios f B s =f B d and, thereby demonstrating the viability of the method. For the ratio of decay constants, we find f B s =f B d ¼ 1:15ð12Þ and for the ratio of mixing matrix elements, we find ¼ 1:13ð12Þ, where in both cases the errors reflect the combined statistical and systematic uncertainties, including an estimate of the size of neglected Oð1=m b Þ effects.