Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study

Nsonwu-Anyanwu, Augusta Chinyere; Ekong, Eworo Raymond; Offor, Sunday Jeremiah; Awusha, Ogar Francis; Orji, Oliver Chukwuma; Umoh, Ediang Idiongo; Owhorji, Jennifer Aleruchim; Emetonjor, Faith Rowland; Usoro, Chinyere Adanna Opara

doi:10.18502/ijrm.v17i3.4515

Cited by 26 publications

(17 citation statements)

References 19 publications

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“…In addition to the excessive generation of ROS, oxidative stress may also be driven by a deficiency in available antioxidant protection. While it is generally appreciated that defective semen quality is commonly associated with low levels of antioxidant protection in semen [ 12 , 138 , 139 ], it is always difficult to differentiate the cause and effect in such circumstances—did the lack of antioxidant protection induce a state of oxidative stress or did the excessive generation of ROS by spermatozoa, infiltrating leukocytes, or, in cases of obesity, adipocytes lead to the depletion of antioxidant equivalents from the semen?…”

Section: Sources Of Ros In the Human Ejaculatementioning

confidence: 99%

Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

et al. 2022

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Reactive oxygen species (ROS) play a critical role in defining the functional competence of human spermatozoa. When generated in moderate amounts, ROS promote sperm capacitation by facilitating cholesterol efflux from the plasma membrane, enhancing cAMP generation, inducing cytoplasmic alkalinization, increasing intracellular calcium levels, and stimulating the protein phosphorylation events that drive the attainment of a capacitated state. However, when ROS generation is excessive and/or the antioxidant defences of the reproductive system are compromised, a state of oxidative stress may be induced that disrupts the fertilizing capacity of the spermatozoa and the structural integrity of their DNA. This article focusses on the sources of ROS within this system and examines the circumstances under which the adequacy of antioxidant protection might become a limiting factor. Seminal leukocyte contamination can contribute to oxidative stress in the ejaculate while, in the germ line, the dysregulation of electron transport in the sperm mitochondria, elevated NADPH oxidase activity, or the excessive stimulation of amino acid oxidase action are all potential contributors to oxidative stress. A knowledge of the mechanisms responsible for creating such stress within the human ejaculate is essential in order to develop better antioxidant strategies that avoid the unintentional creation of its reductive counterpart.

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Section: Sources Of Ros In the Human Ejaculatementioning

confidence: 99%

Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

et al. 2022

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“…As mentioned above, AA is the most abundant water-soluble low-molecular-weight antioxidants in the seminal plasma [ 70 , 113 , 124 ], playing significant protection against oxidative damage to DNA [ 125 ] and prevention of semen agglutination [ 126 ]. Furthermore, AA levels in seminal plasma positively correlate not only with normal semen parameters, such as sperm volume, sperm count and sperm motility [ 127 ] but also with GSH concentration and SOD activity, suggesting a close relationship between different antioxidant defensive mechanisms against ROS-mediated damages [ 128 , 129 ]. Under pathological conditions leading to male infertility, in which the insurgence of oxidative stress is involved, it was observed an overall depletion of AA in the seminal fluid due to the sustained presence of ROS and RNS.…”

Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning

confidence: 99%

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Amorini

Listorti²,

Bilotta³

et al. 2021

Antioxidants

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Under physiological conditions, reactive oxygen species (ROS) play pivotal roles in various processes of human spermatozoa. Indeed, semen requires the intervention of ROS to accomplish different stages of its maturation. However, ROS overproduction is a well-documented phenomenon occurring in the semen of infertile males, potentially causing permanent oxidative damages to a vast number of biological molecules (proteins, nucleic acids, polyunsaturated fatty acids of biological membrane lipids), negatively affecting the functionality and vitality of spermatozoa. ROS overproduction may concomitantly occur to the excess generation of reactive nitrogen species (RNS), leading to oxidative/nitrosative stress and frequently encountered in various human pathologies. Under different conditions of male infertility, very frequently accompanied by morpho-functional anomalies in the sperm analysis, several studies have provided evidence for clear biochemical signs of damages to biomolecules caused by oxidative/nitrosative stress. In the last decades, various studies aimed to verify whether antioxidant-based therapies may be beneficial to treat male infertility have been carried out. This review analyzed the results of the studies published during the last ten years on the administration of low-molecular-weight antioxidants to treat male infertility in order to establish whether there is a sufficient number of data to justify antioxidant administration to infertile males. An analysis of the literature showed that only 30 clinical studies tested the effects of the administration of low-molecular-weight antioxidants (administered as a single antioxidant or as a combination of different antioxidants with the addition of vitamins and/or micronutrients) to infertile males. Of these studies, only 33.3% included pregnancy and/or live birth rates as an outcome measure to determine the effects of the therapy. Of these studies, only 4 were case–control studies, and only 2 of them found improvement of the pregnancy rate in the group of antioxidant-treated patients. Additionally, of the 30 studies considered in this review, only 43.3% were case–control studies, 66.7% enrolled a number of patients higher than 40, and 40% carried out the administration of a single antioxidant. Therefore, it appears that further studies are needed to clearly define the usefulness of antioxidant-based therapies to treat male infertility.

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“…Most of the studies examined ROS parameters in semen; there are only few studies that analyzed oxidative stress parameters in serum, or both in seminal plasma and serum. Serum oxidative stress markers as well as antioxidant profile showed correlation to sperm parameters, showing that serum can be a valuable tool in evaluation of oxidative stress in men [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization

Tulić

Ćurčić

et al. 2020

Srp Arh Celok Lek

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Introduction/Objective. The aim was to assess the effect of oxidative stress parameters on sperm count, motility, and morphology of spermatozoa, and the influence of different semen parameters on the outcome of in vitro fertilization (IVF) procedure ? the number of fertilized oocytes, fertilization, and pregnancy rate of female partners. Method. In 52 male patients superoxide dismutase (SOD), malondialdehyde (MDA), and sulfhydryl (-SH) groups were determined in serum, before beginning the IVF cycle. Semen samples were collected after 2?3 days of sexual abstinence. Results. Patients were divided into two groups, the normozoospermic, and those with pathological sperm findings. The second group was divided into oligozoospermic, asthenozoospermic, and teratozoospermic groups. SOD activity was lower, while MDA and -SH groups, while not significantly, was higher in groups with sperm parameter disorders. Fertilization rate was significantly lower in the group of asthenozoospermia and teratozoospermia (p = 0.034), as well as delivery rate (p = 0.020). The group with oligozoospermia had significantly lower delivery rate (p = 0.013). Conclusion. Our study found higher fertilization and delivery rate in men with normozoospermia. However, no significant correlation between OS markers and semen parameters was found. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III46009]

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Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study

Abstract: .

Cited by 26 publications

References 19 publications

Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization

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