Heavy metals as environmental risk factors for cardiovascular diseases: from the perspective of the renin angiotensin aldosterone system and oxidative stress

Akther, Jobaida; Nabi, A.H.M. Nurun; Ebihara, Akio

doi:10.7831/ras.7.0_68

Cited by 8 publications

(10 citation statements)

References 114 publications

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“…A notable finding of this study was that the positive associations between urinary Cd concentrations and SBP / DBP in Nepal and negative associations in Bangladesh; these differed from the overall trend found in our analyses of all countries. Positive associations between urinary Cd concentrations and blood pressure have frequently been reported in the previous studies [ 20 , 21 , 23 , 24 ]; Cd-induced nephrotoxicity [ 8 – 10 ] and/or endothelial damage [ 12 ] were proposed as explanations. By contrast, the negative associations, as observed in Bangladesh, have also been found, but in far fewer studies [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 90%

“…Increased cardiac output and vasoconstriction are possible effects of Pb exposure [ 11 ]. Upon absorption into the human body, Pb can damage endothelial cells by promoting inflammation and/or oxidative stress [ 11 , 12 , 60 , 61 ]. Lead can influence the activity of endothelial nitric oxide synthase in blood vessels, thereby suppressing vascular relaxation [ 11 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…The biological mechanisms that drive heavy metal-induced blood pressure changes include Cd-induced nephrotoxicity [ 8 – 10 ], as well as increased cardiac output and vasoconstriction triggered by exposure of the sympathetic nervous system to Pb [ 11 ]. Furthermore, As, Cd, and Pb can damage endothelial cells by promoting inflammation and/or oxidative stress [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Mizuno

Shimizu-Furusawa

Konishi

et al. 2021

Environ Health Prev Med

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Background Previous studies have suggested that exposures to heavy metals (arsenic, cadmium, lead, and selenium) may be associated with differences in blood pressure. However, the findings of these studies have been inconsistent. This study was performed to examine the associations between urinary heavy metal concentrations and blood pressure among residents of four Asian countries (Bangladesh, Indonesia, Nepal, and Vietnam). Methods This cross-sectional study examined 1899 adults in four Asian countries. Urinary concentrations of heavy metals were measured by inductively coupled plasma mass spectrometry. A questionnaire survey was administered regarding individual characteristics. Anthropometric measurements (height and weight) were performed. Systolic and diastolic blood pressures were measured after a short rest. Multiple linear regression models were applied to investigate associations between urinary heavy metal concentrations and blood pressure after adjustments for age, sex, and body mass index. Results The geometric means of the urinary concentrations of arsenic, cadmium, lead, and selenium were 84.6, 0.885, 2.09, and 16.5 μg/g creatinine, respectively. The urinary arsenic concentrations were slightly higher than those typically reported in non-polluted populations, while urinary cadmium, lead, and selenium concentrations were equivalent or slightly lower. The urinary lead concentrations were positively associated with both systolic and diastolic blood pressure, but urinary selenium concentrations were negatively associated with them. Conclusions Variations in the urinary concentrations of lead and selenium were associated with blood pressure at low levels of exposure/intake.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Mizuno

Shimizu-Furusawa

Konishi

et al. 2021

Environ Health Prev Med

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“…However, too much can be bad, and these can also be replaced by heavier metals with a similar valence configuration. Cadmium, as one example, can replace iron and copper within cell structures and create oxidative stress (Akther et al, 2019). Several metals that are common pollutants (including arsenic, lead, cadmium, and copper) are associated with an increased risk of cardiovascular disease (CVD) and coronary heart disease (Chowdury et al, 2018).…”

Section: Literature Reviewmentioning

confidence: 99%

“…Metals can impair the ability of antioxidant enzymes to scavenge reactive oxygen species (ROS), which are basically cellular waste products. Metals can also subvert function of the renin-angiotensin-aldosterone system so that control of vasoconstriction and dilation itself creates oxidation and damage to endothelium (Akther et al, 2019). The role of iron in the renin-angiotensin-aldosterone system has been linked to both diabetic kidney disease and CVD (Chowdury et al, 2018).…”

Section: Literature Reviewmentioning

confidence: 99%

The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China

Wang¹,

Newsome²

2021

Gerontology and Geriatric Medicine

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The women of China’s Liaoning province display some morbidities in ways that defy medical explanation. Women have higher rates of hypertension, hypercholesterolemia, and metabolic syndrome than men, an anomaly for all three conditions. Most of these patients also suffer from Type 2 Diabetes Mellitus (T2DM) while there was a negative association between being female and T2DM for the rest of China. Each of these conditions can exist independently, but the increase in both their rates and congruence is a recent phenomenon. Stranger still is that Liaoning women are now presenting in hospital emergency departments with ST-Elevation Myocardial Infarction (STEMI), while diabetics predominantly suffer more benign Non-STEMI (NSTEMI) events. Confounding factors in any attempt to study this phenomenon include trace metals like manganese that have been shown to reduce systolic blood pressure in Asian men and raise it in Asian women. Some of the phenomenon may also be associated with the gene for Apolipoprotein 5, but its recent nature suggests other factors besides lipid profiles. Trace metals in the air, water, and diet of Liaoning province, or any urban environment, could play a role.

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Interactive effects of high temperature and pesticide exposure on oxidative status, apoptosis, and renin expression in kidney of goldfish: Molecular and cellular mechanisms of widespread kidney damage and renin attenuation

Lacy

Rahman

2022

J of Applied Toxicology

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One of many noteworthy consequences of increasing societal reliance on pesticides is their predominance in aquatic environments. These pernicious chemicals interact with high temperatures from global climate change, heat waves, and natural variations to create unstable environments that negatively impact organisms' health.To understand these conditions, we examined the dose-dependent effects of environmentally relevant pesticide mixtures (metolachlor, linuron, isoproturon, tebuconazole, aclonifen, atrazine, pendimethalin, and azinphos-methyl) combined with elevated temperatures (22 control vs. 32 C for 4-week exposure) on renin, dinitrophenyl protein (DNP, an indicator of reactive oxygen species, ROS), 3-nitrotyrosine protein (NTP, an indicator of reactive nitrogen species, RNS), superoxidase dismutase (SOD, an antioxidant), and catalase (CAT, an antioxidant) expressions in the kidneys of goldfish (Carassius auratus). Histopathological analysis showed widespread damage to kidney tissues in high temperature and pesticide co-exposure groups, including rupture of the epithelial layer, hemorrhaging, and degeneration of tubular epithelium. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical analyses demonstrated significant declines in renin receptorlike mRNA and protein expressions in kidney tissues under combined exposure to high temperature and pesticides compared with controls; conversely, expression of DNP, NTP, SOD, and CAT increased in kidney tissues under the same conditions. Apoptotic cells were also increased in co-exposure groups as assessed by in situ terminal deoxynucleotidyl transferase dUTP nick labeling (TUNEL) assay. The enhanced apoptosis in kidneys of heat and pesticides co-exposed fish was associated with increased caspase-3 (a protease enzyme) mRNA levels. Our results demonstrated that high temperature and pesticides induced oxidative/nitrative stress (i.e., ROS/RNS), damaged tissues, increased cellular apoptosis, and suppressed renin expression in kidneys of goldfish.

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Heavy metals as environmental risk factors for cardiovascular diseases: from the perspective of the renin angiotensin aldosterone system and oxidative stress

Cited by 8 publications

References 114 publications

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China

Interactive effects of high temperature and pesticide exposure on oxidative status, apoptosis, and renin expression in kidney of goldfish: Molecular and cellular mechanisms of widespread kidney damage and renin attenuation

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