Heavy metals and probabilistic risk assessment via rice consumption in Thailand

Kukusamude, Chunyapuk; Sricharoen, Phitchan; Limchoowong, Nunticha; Kongsri, Supalak

doi:10.1016/j.foodchem.2020.127402

Cited by 92 publications

(46 citation statements)

References 25 publications

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“…An assessment of the potential risk to human health from oral exposure to the elements investigated in this study was carried out with reference to US EPA recommendations and previous exposure assessment studies [ 14 , 26 , 29 , 57 ]. Using oral reference dose ( RfD ) values listed in Table 5 , general health risk was examined through the calculation of the hazard (HQ) and hazard index (HI).…”

Section: Resultsmentioning

confidence: 99%

Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers

et al. 2021

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A method has been developed, optimised and validated to analyse protein powder supplements on an inductively coupled plasma-sector field mass spectrometer (ICP-SFMS), with reference to ICH Guideline Q2 Validation of Analytical Procedures: Text and Methodology. This method was used in the assessment of twenty-one (n = 21) elements (Al, Au, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Pb, Pt, Sn, Ti, Tl, V) to evaluate the safety of thirty-six (n = 36) protein powder samples that were commercially available in the Irish marketplace in 2016/2017. Using the determined concentrations of elements in samples (µg·kg−1), a human health risk assessment was carried out to evaluate the potential carcinogenic and other risks to consumers of these products. While the concentrations of potentially toxic elements were found to be at acceptable levels, the results suggest that excessive and prolonged use of some of these products may place consumers at a slightly elevated risk for developing cancer or other negative health impacts throughout their lifetimes. Thus, the excessive use of these products is to be cautioned, and consumers are encouraged to follow manufacturer serving recommendations.

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Section: Resultsmentioning

confidence: 99%

Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers

et al. 2021

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“…Strict regulations for certain elements are required, especially for heavy metals that belong to the first category and capable of resulting in potential harm to human health. 29 Nickel, in particular, is regarded as extremely poisonous and remains in the atmosphere forever and thus can easily bioaccumulate in humans and marine animals. In high concentrations, even though minor quantities of nickel enter the atmosphere, they can be preserved permanently, thereby resulting in adverse environmental effects.…”

Section: Introductionmentioning

confidence: 99%

Ultratrace Detection of Nickel(II) Ions in Water Samples Using Dimethylglyoxime-Doped GQDs as the Induced Metal Complex Nanoparticles by a Resonance Light Scattering Sensor

et al. 2021

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This study aimed to synthesize dimethylglyoxime (DMG) (N-source)-doped graphene quantum dots (N-GQDs) via simultaneous pyrolysis of citric acid and 1.0% (w/v) DMG. The maximum excitation wavelength (λ max , ex = 380 nm) of the N-GQD solution (49% quantum yield (QY)) was a red shift with respect to that of bare GQDs (λ max , ex = 365 nm) (46% QY); at the same maximum emission wavelength (λ max , em = 460 nm), their resonance light scattering (RLS) intensity peak was observed at λ max , ex/em = 530/533 nm. FTIR, X-ray photoelectron spectroscopy, XRD, energy-dispersive X-ray spectroscopy, and transmission electron microscopy analyses were performed to examine the synthesized materials. The selective and sensitive detection of Ni 2+ using the RLS intensity was performed at 533 nm under the optimum conditions consisting of both 25 mg L –1 N-GQDs and 2.5 mg L –1 DMG in the ammonium buffer solution of pH 9.0. The linearity of Ni 2+ was 50.0–200.0 μg L –1 with a regression line, y = 5.031 x – 190.4 ( r 2 = 0.9948). The limit of detection (LOD) and the limit of quantitation (LOQ) were determined to be 20.0 and 60.0 μg L –1 , respectively. The method precision expressed as % RSDs was 4.90 for intraday ( n = 3 × 3) and 7.65 for interday ( n = 5 × 3). This developed method afforded good recoveries of Ni 2+ in a range of 85–108% when spiked with real water samples. Overall, this innovative method illustrated the identification and detection of Ni 2+ as a DMG complex with N-GQDs, and the detection was highly sensitive and selective.

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“…Heavy metals exist in water, air, soil, and food. Previous studies [19,20] have measured the levels of heavy metals in rice, estimated potential cancer risks, and highlighted the association between heavy metals concentration in rice and cancers risks. Rice is mostly consumed by Iranian people as the main meal for both lunch and dinner.…”

Section: Introductionmentioning

confidence: 99%

“…Rice is mostly consumed by Iranian people as the main meal for both lunch and dinner. Kukusamude et al (2020) [19] have measured heavy metals including chromium, zinc, nickel, copper, manganese, cobalt , arsenic, and cadmium in 55 Thai local rice, and assessed the potential impact on Thai population by means of probabilistic approach. They found that the maximum cancer probabilities over the lifetime consumption of Thai local rice were in the range of 5 in 10,000 to 3 in 1000 chances in developing cancer.…”

Section: Introductionmentioning

confidence: 99%

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Kiani

Amin

Bagheri

et al. 2020

Preprint

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BackgroundExposure to environmental pollutants such as heavy metals has been introduced as a possible contributor to increasing the risk of colon cancer. We aim to explore the associations between heavy metals and the age-standardized incidence rate (ASR) colon cancer in Northeastern Iran.MethodsCancer data were drawn from the population-based cancer registry of Golestan province, Northeastern Iran. The heavy metals’ samples were collected from 69 rice milling plants in the study area. Then, the concentration level of seven heavy metals, including Cadmium, Nickel, Cobalt, Copper, Selenium, Lead, and Zink was measured. The Kriging algorithm was used to interpolate the heavy metals' concentration on the surface of the study area. The exploratory regression analysis was conducted to build the ordinary least squares (OLS) models on every possible combination of the candidate explanatory variables. Finally, the best OLS models were chosen to show the effect of heavy metals on colon cancer.ResultsGenerally, heavy metals were higher in central part of the province. The analyses showed that the high concentration of Cobalt was associated with the high ASR of colon cancer in men. In contrast, the Selenium concentration was higher in areas with lower ASR of colon cancer in men. A significant regression equation for men colon cancer was found (F(4,137)=38.304, P<.000) with an adjusted R2 of 0.77. The predicted ASR of men colon cancer was -58.3581 with the coefficients for Cobalt= 120.329780; Cadmium= 80.603505; Selenium= -6.069037; Nickel= -3.086802; and Zink= -0.405843. The effect of Copper and Lead on men colon cancer was not significant. We did not find a significant model for women colon cancer.ConclusionThere may be a possible negative correlation between selenium concentration and lower risk of colon cancer in men. Furthermore, the higher cobalt concentration may be related to an increased risk of men colon cancer.

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Heavy metals and probabilistic risk assessment via rice consumption in Thailand

Cited by 92 publications

References 25 publications

Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers

Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers

Ultratrace Detection of Nickel(II) Ions in Water Samples Using Dimethylglyoxime-Doped GQDs as the Induced Metal Complex Nanoparticles by a Resonance Light Scattering Sensor

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

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