Heavy Metal Transport and Detoxification by Crustacean Epithelial Lysosomes

Ahearn, Gregory A.; Sterling, Kenneth; Mandal, Prabir K.; Roggenbeck, Barbara A.

doi:10.1007/978-1-60327-229-2_3

Cited by 4 publications

(6 citation statements)

References 42 publications

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“…Toxic metals interact with binding sites of membrane transport proteins and by this way are able to gain access to the intracellular compartments where they are a danger to normal biochemical and physiological functions (Ahearn et al, 2010; Wood, 2012). …”

Section: Branchial Transport and Bioaccumulation Of Toxic Metalsmentioning

confidence: 99%

“…Hypothetical entry of toxic metals across the gill epithelium of marine and estuarine crustaceans is presented by a model based on ionic mimicry (Figures 10 and 11 ). Toxic metals interact with binding sites of membrane transport proteins and by this way are able to gain access to the intracellular compartments where they are a danger to normal biochemical and physiological functions (Ahearn et al, 2010 ; Wood, 2012 ).…”

Section: Branchial Transport and Bioaccumulation Of Toxic Metalsmentioning

confidence: 99%

“…Metals interact with apically located voltage-independent, non-selective Ca 2+ channels (Figure 10 ). This model is based on experimental evidence indicating that Cd 2+ , Zn 2+ , and Pb 2+ are transported across the crustacean gill epithelial cell by apically located voltage—independent Ca 2+ channels driven by electrochemical gradients in Crustacea (Bjerregaard and Depledge, 1994 ; Pedersen and Bjerregaard, 2000 ; Ahearn et al, 2010 ) and fish (Wood, 2012 ). Toxic metals competes with the basolaterally located Na + /K + -ATPase that generates apically and basolaterally located secondary active transport mechanisms.…”

Section: Branchial Transport and Bioaccumulation Of Toxic Metalsmentioning

confidence: 99%

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Multiple functions of the crustacean gill: osmotic/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals

Henry¹,

Lucu²,

Onken³

et al. 2012

Front. Physio.

349

286

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The crustacean gill is a multi-functional organ, and it is the site of a number of physiological processes, including ion transport, which is the basis for hemolymph osmoregulation; acid-base balance; and ammonia excretion. The gill is also the site by which many toxic metals are taken up by aquatic crustaceans, and thus it plays an important role in the toxicology of these species. This review provides a comprehensive overview of the ecology, physiology, biochemistry, and molecular biology of the mechanisms of osmotic and ionic regulation performed by the gill. The current concepts of the mechanisms of ion transport, the structural, biochemical, and molecular bases of systemic physiology, and the history of their development are discussed. The relationship between branchial ion transport and hemolymph acid-base regulation is also treated. In addition, the mechanisms of ammonia transport and excretion across the gill are discussed. And finally, the toxicology of heavy metal accumulation via the gill is reviewed in detail.

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Section: Branchial Transport and Bioaccumulation Of Toxic Metalsmentioning

confidence: 99%

Section: Branchial Transport and Bioaccumulation Of Toxic Metalsmentioning

confidence: 99%

Section: Branchial Transport and Bioaccumulation Of Toxic Metalsmentioning

confidence: 99%

See 1 more Smart Citation

Multiple functions of the crustacean gill: osmotic/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals

Henry¹,

Lucu²,

Onken³

et al. 2012

Front. Physio.

349

286

View full text Add to dashboard Cite

show abstract

“…Among these candidates, we found amiloride‐sensitive sodium channels, membrane ATPases and ABC and dicarboxylate transporters. These proteins are either antiporters for metal cations or are involved in cellular mechanisms for heavy metal vacuolar sequestration (Ahearn, Sterling, Mandal, & Roggenbeck, ) or in cellular metal homeostasis and detoxification (e.g., Lee, Yang, Zhitnitsky, Lewinson, & Rees, ; Sooksa‐Nguan et al, ). Another set of interesting candidates are the proteins annotated as syntaxin‐5‐like proteins with a SNARE domain, which are involved in vesicle tethering and fusion associated with copper ion homeostasis (Norgate et al, ) and, in addition to being significantly overexpressed in both specialists, also show signals of positive selection in D. tilosensis .…”

Section: Discussionmentioning

confidence: 99%

“…Among these candidates, we found amiloride-sensitive sodium channels, membrane ATPases and ABC and dicarboxylate transporters. These proteins are either antiporters for metal cations or are involved in cellular mechanisms for heavy metal vacuolar sequestration (Ahearn, Sterling, Mandal, & Roggenbeck, 2010) (Norgate et al, 2010) and, in addition to being significantly overexpressed in both specialists, also show signals of positive selection in D. tilosensis.…”

Section: Genetic Changes Matching Phenotypic Convergence: Metal-indmentioning

confidence: 99%

Chance and predictability in evolution: The genomic basis of convergent dietary specializations in an adaptive radiation

et al. 2019

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The coexistence of multiple eco‐phenotypes in independently assembled communities makes island adaptive radiations the ideal framework to test convergence and parallelism in evolution. In the radiation of the spider genus Dysdera in the Canary Islands, species diversification occurs concomitant with repeated events of trophic specialization. These dietary shifts, to feed primarily on woodlice, are accompanied by modifications in morphology (mostly in the mouthparts), behaviour and nutritional physiology. To gain insight into the molecular basis of this adaptive radiation, we performed a comprehensive comparative transcriptome analysis of five Canary Island Dysdera endemics representing two evolutionary and geographically independent events of dietary specialization. After controlling for the potential confounding effects of hemiplasy, our differential gene expression and selective constraint analyses identified a number of genetic changes that could be associated with the repeated adaptations to specialized diet of woodlice, including some related to heavy metal detoxification and homeostasis, the metabolism of some important nutrients and venom toxins. Our results shed light on the genomic basis of an extraordinary case of dietary shift convergence associated with species diversification. We uncovered putative molecular substrates of convergent evolutionary changes at different hierarchical levels, including specific genes, genes with equivalent functions and even particular amino acid positions. This study improves our knowledge of rapid adaptive radiations and provides new insights into the predictability of evolution.

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Bioaccumulation/Storage/Detoxification

Weis

2013

Physiological, Developmental and Behavioral Effects of Marine Pollution

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Heavy Metal Transport and Detoxification by Crustacean Epithelial Lysosomes

Cited by 4 publications

References 42 publications

Multiple functions of the crustacean gill: osmotic/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals

Multiple functions of the crustacean gill: osmotic/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals

Chance and predictability in evolution: The genomic basis of convergent dietary specializations in an adaptive radiation

Bioaccumulation/Storage/Detoxification

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