Heavy Metal Toxicity: Oxidative Stress Parameters and DNA Repair

Moura, Dinara Jaqueline; Péres, Valéria Flores; Jacques, Rosângela Assis; Saffi, Jenifer

doi:10.1007/978-3-642-22081-4_9

Cited by 17 publications

(11 citation statements)

References 81 publications

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“…e1460048-8 damage of adenine or guanine, single and double strand breaks and chromosome aberrations in the genome of seed embryo, thus establishing a link between DNA damage and reduced germination potential of seeds under heavy metal stress. [135][136][137][138][139] Consistent with this observation, freshly harvested unaged Arabidopsis seeds have been found to display transcriptional upregulation of DNA damage responsive genes during the earliest stages of germination, coincident with DNA repair synthesis. 140 Together, these observations have indicated the importance of DNA damage repair function for maintaining the genome integrity of in seed embryo during imbibition and before the initiation of cell division to reduce growth inhibition and mutagenesis during the subsequent stages of seedling development in presence of heavy metals.…”

Section: B=w In Print; Colour Onlinementioning

confidence: 79%

Oxidative and genotoxic damages in plants in response to heavy metal stress and maintenance of genome stability

Dutta

Mitra

Agarwal

et al. 2018

Plant Signaling & Behavior

108

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Plants, being sessile in nature, are constantly exposed to various environmental stresses, such as solar UV radiations, soil salinity, drought and desiccation, rehydration, low and high temperatures and other vast array of air and soil borne chemicals, industrial waste products, metals and metalloids. These agents, either directly or indirectly via the induction of oxidative stress and overproduction of reactive oxygen species (ROS), frequently perturb the chemical or physical structures of DNA and induce both cytotoxic or genotoxic stresses. Such condition, in turn, leads to genome instability and thus eventually severely affecting plant health and crop yield. With the growing industrialization process and non-judicious use of chemical fertilizers, the heavy metal mediated chemical toxicity has become one of the major environmental threats for the plants around the globe. The heavy metal ions cause damage to the structural, enzymatic and non-enzymatic components of plant cell, often resulting in loss of cell viability, thus negatively impacting plant growth and development. Plants have also evolved with an extensive and highly efficient mechanism to respond and adapt under such heavy metal toxicity mediated stress conditions. In addition to morpho-anatomical, hormonal and biochemical responses, at the molecular level, plants respond to heavy metal stress induced oxidative and genotoxic damage via the rapid change in the expression of the responsive genes at the transcriptional level. Various families of transcription factors play crucial role in triggering such responses. Apart from transcriptional response, epigenetic modifications have also been found to be essential for maintenance of plant genome stability under genotoxic stress. This review represents a comprehensive survey of recent advances in our understanding of plant responses to heavy metal mediated toxicity in general with particular emphasis on the transcriptional and epigenetic responses and highlights the importance of understanding the potential targets in the associated pathways for improved stress tolerance in crops.

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Section: B=w In Print; Colour Onlinementioning

confidence: 79%

Oxidative and genotoxic damages in plants in response to heavy metal stress and maintenance of genome stability

Dutta

Mitra

Agarwal

et al. 2018

Plant Signaling & Behavior

108

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“…Even though Zn is an essential micronutrient for growth and metabolism of plants [2] and it is necessary for chlorophyll production [49], harmful responses to high Zn concentrations may be closely related to the generation of reactive oxygen species (ROS). Additionally, displacement of some other metals from the active sites in proteins [50] can affect chlorophyll biosynthesis and damage the photosynthetic system [51]. Chlorophyll content has been classified as a reliable indicator of contamination and toxicity of heavy metals in plants [52].…”

Section: Resultsmentioning

confidence: 99%

Foliar Application of Zinc Oxide Nanoparticles and Zinc Sulfate Boosts the Content of Bioactive Compounds in Habanero Peppers

García-López

Niño-Medina

Olivares‐Sáenz

et al. 2019

Plants

146

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The physiological responses of habanero pepper plants (Capsicum chinense Jacq.) to foliar applications of zinc sulphate and zinc nano-fertilizer were evaluated in greenhouse trials. The effect of the supplement on fruit quality of habanero pepper was particularly observed. Habanero pepper plants were grown to maturity, and during the main stages of phenological development, they were treated with foliar applications of Zn at concentrations of 1000 and 2000 mg L−1 in the form of zinc sulfate (ZnSO4) and zinc oxide nanoparticles (ZnO NPs). Additional Zn was not supplied to the control treatment plants. ZnO NPs at a concentration of 1000 mg L−1 positively affected plant height, stem diameter, and chlorophyll content, and increased fruit yield and biomass accumulation compared to control and ZnSO4 treatments. ZnO NPs at 2000 mg L−1 negatively affected plant growth but significantly increased fruit quality, capsaicin content by 19.3%, dihydrocapsaicin by 10.9%, and Scoville Heat Units by 16.4%. In addition, at 2000 ZnO NPs mg L−1 also increased content of total phenols and total flavonoids (soluble + bound) in fruits (14.50% and 26.9%, respectively), which resulted in higher antioxidant capacity in ABTS (2,2′azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), DPPH (2,2-diphenyl-1-picrylhydrazyl), and FRAP (ferric reducing antioxidant power) (15.4%, 31.8%, and 20.5%, respectively). These results indicate that application of ZnO NPs could be employed in habanero pepper production to improve yield, quality, and nutraceutical properties of fruits.

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“…It is also a component of several enzymatic systems, participating in electron flow and catalysis of redox reactions (Moura et al, 2012). A sufficient intracellular copper ion level must be maintained in order to establish these important mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…This allows copper cations to enter the cytoplasm, initiating degenerative processes that probably cause alteration in different metabolic pathways. The chlorophyll degradation of photobiont was observed as a sign of damage (Garty et (Moura et al, 2012). The concentration of malondialdehyde (MDA) increased with the increase in copper concentration in the nutrient solution (Monnet et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Copper induced physiological changes and oxidative damage in lichen Ramalina farinacea

Sujetovienė¹

2015

biologija

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Copper is an essential element for all organisms but can reach toxic concentrations as a result of human activities. The aim of the present study was to investigate physiological effects of copper on the lichen Ramalina farinacea (L.) Ach. The effect of copper on the chlorophyll content, fluorescence and oxidative status was assessed. The chlorophyll a content was not significantly different from the control. The chlorophyll b content was significantly higher at any tested Cu 2+ concentration in comparison with the control. F v /F m values decreased significantly in R. farinacea following 50 mg Cu and higher concentrations. MDA increased significantly after exposure to 100 and 500 mg Cu concentrations.

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Heavy Metal Toxicity: Oxidative Stress Parameters and DNA Repair

Cited by 17 publications

References 81 publications

Oxidative and genotoxic damages in plants in response to heavy metal stress and maintenance of genome stability

Oxidative and genotoxic damages in plants in response to heavy metal stress and maintenance of genome stability

Foliar Application of Zinc Oxide Nanoparticles and Zinc Sulfate Boosts the Content of Bioactive Compounds in Habanero Peppers

Copper induced physiological changes and oxidative damage in lichen Ramalina farinacea

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