Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)

Hossain, Zakir; Hossain, Md. Saddam; Ema, Noore Safa; Omri, Abdelwahab

doi:10.1016/j.heliyon.2021.e08285

Cited by 12 publications

(6 citation statements)

References 71 publications

(83 reference statements)

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“…The present study findings also showed an upregulation of the IL-1β gene in the group exposed to waterborne cadmium without A. cepa treatments. Similarly, earlier studies reported significant upregulation of IL-1β, IL-6, and TNF-α genes in fish exposed to heavy metals pollution (Yildirim & Danabas 2014;Hossain et al (2021). This increase can be interpreted as a body response of injured tissues to alleviate Cd-induced stress (Schoenborn & Wilson 2007;Ma et al 2018).…”

Section: Discussionmentioning

confidence: 65%

Onion (Allium cepa) improves Nile tilapia (Oreochromis niloticus) resistance to saprolegniasis (Saprolegnia parasitica) and reduces immunosuppressive effects of cadmium

et al. 2022

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The present study investigated the protective effects of dietary Allium cepa against Saprolegnia parasitica infections and the amelioration of cadmium-induced immunosuppression in Oreochromis niloticus. Saprolegnia isolates were recovered during an outbreak of saprolegniasis in farmed O. niloticus raised in a poor aquatic environment. Isolates were identified phenotypically as S. parasitica. Results were confirmed further by ITS gene sequencing. Four fish groups were kept in water with cadmium (1.5 mg/L) and fed for 30 days on a diet supplemented with crude or alcoholic extracts of A. cepa using two concentrations (0.5% or 1%). Positive (with Cd) and negative (without Cd) control fish groups were given the basal diet. The 96 h LC50 value of Cd in tilapia was (15.1 mg/L Cd). Fish exposed to Cd showed poor growth performance parameters, abnormal biochemical measurements, impaired immunological responses, and high oxidative stress indicators. Feeding tilapia on A. cepa-supplemented diets enhanced their growth performance (WG, SGR) and improved the nonspecific immune responses (WBCs, total protein, globulins, lysozyme, myeloperoxidase, and antiproteases). The inclusion of A. cepa in the diets reduced the oxidative stress (GST, SOD) and significantly decreased fish mortality after the challenge with S. parasitica. Dietary supplementation with A. cepa reduced cadmium accumulation in fish organs and up-regulated IL-1β and IFNɣ levels. The most favorable benefits were obtained by the addition of 0.5% A. cepa extract. Our results highlight the immunostimulatory properties of A. cepa dietary supplementation for farmed tilapia and recommend its use prophylactically to control saprolegniasis and mitigate cadmium adverse effects.

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Section: Discussionmentioning

confidence: 65%

Onion (Allium cepa) improves Nile tilapia (Oreochromis niloticus) resistance to saprolegniasis (Saprolegnia parasitica) and reduces immunosuppressive effects of cadmium

et al. 2022

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“…A previous study showed that fish can be used as an experimental model and that fish play an important role as bio-indicators of potential risks. Furthermore, fish behavior also has a role as a biomarker in the polluted aquatic environment ( 48 ). Previous studies have shown that lysozyme activity is significantly increased in Nile tilapia cultured in acidic water at pH 4 for 2 weeks ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Pan

Tsai

et al. 2022

Front. Immunol.

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The water environment plays an important role in animal physiology. In this study, we sought to evaluate the effect of the acid environment on the Oreochromis niloticus (Nile tilapia) internal microenvironment immune response compare to the mouse macrophage model (J77A.1). The acid environment treated mouse macrophage J774A.1 model have shown that acidic treatment is able to polarize macrophages into M2-like macrophages via an increase in Ym1, Tgm2, Arg1, Fizz1, and IL-10 expression. Metabolic analysis of mouse macrophages (J774A.1) at pH 2 vs. pH 7 and pH 4 vs. pH 7 have been shown to promote the expression of intracellular acetylcholine, choline, prochlorperazine, L-leucine, and bisphenol A,2-amino-3-methylimidazo[4,5-f] quinolone metabolites in the M2-like macrophage. Immune gene expression of the O. niloticus spleen and liver treated at pH 2, 4, and 7 was shown to reduce TNF-α, IL-1 β, IL-8, and IL-12 expression compared to pH 7 treatment. Immune gene was induced in O. niloticus following culture at pH 5, 6, and 7 fresh water environment. Taken together, we found that the acid internal environment polarizes tissues into an M2 macrophage developmental microenvironment. However, if the external environment is acid, tissues are exposed to an M1 macrophage developmental microenvironment.

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“…Whole blood from each fish was collected into 0.5 ml anti‐coagulated centrifuge tubes using a heparinized capillary tube (5 μl of 10 μg/ml heparin was used) as previously described (Xiao et al, 2018). For RBC counts, the blood of 3 fish in each tank was used according to the method mentioned previously (Hossain et al, 2021). The mean RBC concentration of the 3 fish in each tank was set as one biological sample ( N = 1).…”

Section: Methodsmentioning

confidence: 99%

Short‐term exposure of 17α‐ethynylestradiol impairs water homeostasis by inhibiting osmoregulatory and cortisol regulating genes in adult zebrafish

Xie

et al. 2022

Aquaculture Research

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The aim was to study the effect of 17α‐ethynylestradiol (EE2) on osmoregulation of fish, adult zebrafish (Danio rerio) were exposed to 10 ng/L and 100 ng/L of EE2 for 7 days. After exposure, EE2 induced body oedema, trichangiectasis in the skin and protrusion of the proptosis and significantly elevated the condition factor, water weight and water content, decreased the RBC count and HCT of the fish. In addition, various histopathological damages in the gill and kidney were observed. We therefore speculate that EE2 exposure may disrupt water homeostasis in zebrafish. Further research found that the mRNA levels of crh, crhr and acth were remarkably down‐regulated in the brain, in accordance with the decreased level of plasma cortisol. Moreover, remarkably increased aqp3a and aqp1a1 mRNA levels in the gill were observed, suggesting elevated water intake in the gill. Meanwhile, decreased expression of atp1a1a.1 and the activity of Na+, K+‐ATPase in the gill, which might have resulted from lower plasma cortisol levels, were also present, in consistence with the lesions of histocyte. Moreover, suppressed expression of atp1a1a.4 and the activity of Na+, K+‐ATPase in the kidney were probably resulted from decreased plasma cortisol levels and low expression of avp in the brain.

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Heavy metal toxicity in Buriganga river alters the immunology of Nile tilapia (Oreochromis niloticus L)

Cited by 12 publications

References 71 publications

Onion (Allium cepa) improves Nile tilapia (Oreochromis niloticus) resistance to saprolegniasis (Saprolegnia parasitica) and reduces immunosuppressive effects of cadmium

Onion (Allium cepa) improves Nile tilapia (Oreochromis niloticus) resistance to saprolegniasis (Saprolegnia parasitica) and reduces immunosuppressive effects of cadmium

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Short‐term exposure of 17α‐ethynylestradiol impairs water homeostasis by inhibiting osmoregulatory and cortisol regulating genes in adult zebrafish

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