Heavy metal pollution and co-selection for antibiotic resistance: A microbial palaeontology approach

Dickinson, Andrew W.; Power, Aidan; Hansen, Mogens Herman; Brandt, Kristian K.; Piliposian, G.T.; Appleby, P. G.; O’Neill, Paul; Jones, Robert T.; Sierocinski, Pawel; Koskella, Britt; Vos, Michiel

doi:10.1016/j.envint.2019.105117

Cited by 172 publications

(104 citation statements)

References 72 publications

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“…Although AMR genes are ancient 48 and have evolved as a result of microbial interactions, as for example evidenced by their 49 presence in permafrost samples minimally impacted by anthropogenic activity (D'Costa et al 50 2011), the misuse of antibiotics in healthcare and agriculture has caused a rapid and 51 worrying increase in their prevalence and mobility (Knapp et al 2010). The environmental 52 dimensions of AMR evolution are increasingly appreciated (Wellington et 2017; Dickinson et al 2019) or by altering transfer dynamics of AMR plasmids (Klümper et 64 al. 2017(Klümper et 64 al.…”

Section: Introduction 46mentioning

confidence: 99%

Zinc can counteract selection for ciprofloxacin resistance

Vos

Sibleyras

et al. 2019

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Phone: (+44)7497497338 21 ORCID: 0000-0002-4169-6548 22 Graphical abstract 23 24One sentence summary 25The minimal selective concentration for a ciprofloxacin resistant E. coli strain increases up to 26 5-fold in the presence of Zinc cations. 27 3 Abstract 28 Antimicrobial resistance (AMR) has emerged as one of the most pressing global threats to 29 public health. AMR evolution occurs in the clinic but also in the environment, where low 30 concentrations of antibiotics and heavy metals can respectively select and co-select for 31 resistance. While the selective potential for AMR of both antibiotics and metals is 32 increasingly well-characterized, studies exploring the combined effect of both types of 33 selective agents are rare. It has previously been demonstrated that fluoroquinolone 34 antibiotics such as ciprofloxacin can chelate metal ions. To investigate how ciprofloxacin 35 resistance is affected by the presence of metals, we quantified selection dynamics between 36 a ciprofloxacin-susceptible and an isogenic ciprofloxacin-resistant Escherichia coli MG1655 37 strain across a gradient of ciprofloxacin concentrations in the presence and absence of Zinc 38 cations (Zn 2+ ). The minimal selective concentration (MSC) for ciprofloxacin resistance 39 significantly increased up to 5-fold in the presence of Zn 2+ . No such effect on the MSC was 40 found for gentamicin, an antibiotic not known to chelate zinc cations. Environmental pollution 41 usually consists of complex mixtures of antimicrobial agents. Our findings highlight the 42 importance of taking antagonistic as well as additive or synergistic interactions between 43 different chemical compounds into account when considering their effect on bacterial 44 resistance evolution. 45

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Section: Introduction 46mentioning

confidence: 99%

Zinc can counteract selection for ciprofloxacin resistance

Vos

Sibleyras

et al. 2019

Preprint

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“…Since the induction of Cu resistance provides a clear advantage in surviving on or near metallic Cu, it raises the question to what extent resistance determinants can be transferred to or protect other bacterial species. In addition, co-selection between metal resistance and antibiotic resistance has often been reported (Baker-Austin et al, 2006;Stepanauskas et al, 2006;Dickinson et al, 2019;Nguyen et al, 2019). One way to amplify the killing efficiency of Cu metal could be to limit the extant AOC levels, that the bacteria need to synthesize and energize those resistance determinants.…”

Section: Resultsmentioning

confidence: 99%

Copper Resistance Mediates Long-Term Survival of Cupriavidus metallidurans in Wet Contact With Metallic Copper

et al. 2020

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“…Also, correlations of Tc R genes prevalences with the presence of heavy metals, also present in the Huelva estuary, such as Cu, Mn, Ni, and Zn have been reported (Knapp et al, 2017). Recently, in a paleontological study of sediments contaminated with Zn, bacteria were found to share Tm R with Zn resistance, which was related to Zn concentration (Dickinson et al, 2019). The co-selection for Zn R likely might be one of the causes for the prevalence of Tm R in bacteria from the Huelva estuary.…”

Section: Prevalence Of Resistance To Individual Antibiotics Among Ap mentioning

confidence: 94%

Bacteria From the Multi-Contaminated Tinto River Estuary (SW, Spain) Show High Multi-Resistance to Antibiotics and Point to Paenibacillus spp. as Antibiotic-Resistance-Dissemination Players

2020

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Bacterial resistance to antibiotics is an ever-increasing phenomenon that, besides clinical settings, is generally assumed to be prevalent in environmental soils and waters. The analysis of bacteria resistant to each one of 11 antibiotics in waters and sediments of the Huelva's estuary, a multi-contaminated environment, showed high levels of bacteria resistant mainly to Tm, among others. To further gain knowledge on the fate of multi-drug resistance (MDR) in environmental bacteria, 579 ampicillinresistant bacteria were isolated tested for resistance to 10 antibiotics. 92.7% of the isolates were resistant to four or more antibiotic classes, indicating a high level of multi-resistance. 143 resistance profiles were found. The isolates with different MDR profiles and/or colony morphologies were phylogenetically ascribed based on 16S rDNA to phyla Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes, including 48 genera. Putative intrinsic resistance was detected in different phylogenetic groups including genera Altererythrobacter, Bacillus, Brevundimonas, Erythrobacter, Mesonia, Ochrobactrum, and Ponticaulis. Correlation of the presence of pairs of the non-intrinsicresistances in phylogenetic groups based on the kappa index (κ) highlighted the co-habitation of some of the tested pairs at different phylogenetic levels. Maximum correlation (κ = 1.

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Heavy metal pollution and co-selection for antibiotic resistance: A microbial palaeontology approach

Cited by 172 publications

References 72 publications

Zinc can counteract selection for ciprofloxacin resistance

Zinc can counteract selection for ciprofloxacin resistance

Copper Resistance Mediates Long-Term Survival of Cupriavidus metallidurans in Wet Contact With Metallic Copper

Bacteria From the Multi-Contaminated Tinto River Estuary (SW, Spain) Show High Multi-Resistance to Antibiotics and Point to Paenibacillus spp. as Antibiotic-Resistance-Dissemination Players

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