Heavy metal contamination of prenatal vitamins

Schwalfenberg, Gerry; Rodushkin, Ilia; Genuis, Stephen J.

doi:10.1016/j.toxrep.2018.02.015

Cited by 29 publications

(18 citation statements)

References 62 publications

(88 reference statements)

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“…), 2.5 mg/kg ( p.o .) [[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]] and at pre-clinical dose of 3 mg/kg (p.o. ), 6-8 mg/kg (p.o), 0.3 mg/kg, (i.p.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

2019

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Autism is the category used within the newest edition of the diagnostic and statistical manual of neurodevelopmental disorders. Autism is a spectrum of disorder where a variety of behavioural patterns observed in autistic patients, such as stereotypes and repetitive behavior, hyperexcitability, depression-like symptoms, and memory and cognitive dysfunctions. Neuropathological hallmarks that associated with autism are mitochondrial dysfunction, oxidative stress, neuroinflammation, Neuro-excitation, abnormal synapse formation, overexpression of glial cells in specific brain regions like cerebellum, cerebral cortex, amygdala, and hippocampus. ICV injection of propionic acid (PPA) (4 μl/0.26 M) mimics autistic-like behavioral and biochemical alterations in rats. Literature findings reveal that there is a link between autism neuronal mitochondrial coenzyme-Q10 (CoQ10) and ETC-complexes dysfunctions are the keys pathogenic events for autism. Therefore, in the current study, we explore the neuroprotective interventions of Solanesol (SNL) 40 and 60 mg/kg alone and in combination with standard drugs Aripiprazole (ARP) 5 mg/kg, Citalopram (CTP) 10 mg/kg, Memantine (MEM) 5 mg/kg and Donepezil (DNP) 3 mg/kg to overcome behavioral and biochemical alterations in PPA induced experimental model of Autism. Chronic treatment with SNL 60 mg/kg in combination with standard drug shows a marked improvement in locomotion, muscle coordination, long-term memory and the decrease in depressive behavior. While, chronic treatment of SNL alone and in combination with standard drug aripiprazole, citalopram, donepezil, and memantine shows the Neuroprotective potential by enhancing the cognitive deficits, biochemical alterations along with reducing the level of inflammatory mediators and oxidative stress.

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“…), 2.5 mg/kg ( p.o .) [[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]] and at pre-clinical dose of 3 mg/kg (p.o. ), 6-8 mg/kg (p.o), 0.3 mg/kg, (i.p.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

2019

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“…It can be assumed that this urban coastal population had a higher standard of living, consumed an urban diet including ready-made meals, had an increased consumption of citrate-containing cool drinks, and frequently used cosmetics, various Al-containing hygiene products and Al-containing antacids and medications. Recently, it has been shown that prenatal vitamins and other supplements (both prescribed and self-medicated) sold in Canada and other countries contain various neurotoxic elements including Al, Pb, As, titanium, and thoreum [45]. The consumption of these products may pose a danger to the developing foetus, which has an immature detoxification mechanism when compared with its mother [45].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been shown that prenatal vitamins and other supplements (both prescribed and self-medicated) sold in Canada and other countries contain various neurotoxic elements including Al, Pb, As, titanium, and thoreum [45]. The consumption of these products may pose a danger to the developing foetus, which has an immature detoxification mechanism when compared with its mother [45]. Thus, the mean concentration of Al in serum is higher in the urban coastal population, although the ranges are very similar in both populations, viz.…”

Section: Discussionmentioning

confidence: 99%

In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

Röllin

Channa

Olutola

et al. 2020

IJERPH

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Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its effects on birth outcomes and possible synergistic effects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman’s rank correlation coefficients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities.

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“…Cosmetics use in pregnancy is not uncommon. Schwalfenberg et al, 2018 reported that prenatal lead exposure is associated with a greater risk of premature delivery, reduced postnatal growth, lower mental growth in childhood, schizophrenia and dementia in adulthood [39]. Even low level of Cd exposure may avert neurodevelopment [40].…”

Section: Introductionmentioning

confidence: 99%

Heavy Metals: The Notorious Daredevils of Daily Personal Care Products- Mini Review

Mohiuddin¹

2019

SARJPS

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Personal care products and facial cosmetics are commonly used by millions of consumers on a daily basis. Direct application of cosmetics on human skin makes it vulnerable to a wide variety of ingredients. Despite the protecting role of skin against exogenous contaminants, some of the ingredients in cosmetic products are able to penetrate the skin and to produce systemic exposure. Consumers' knowledge of the potential risks of the frequent application of cosmetic products should be improved. While regulations exist in most of the high-income countries, in low income countries there is a lack of similar standards. In most countries for which these legal regulations have been identified, restrictions on the permissible level of heavy metals are strict. There is a need for enforcement of existing rules, and rigorous assessment of the effectiveness of these regulations. The occurrence of metals in cosmetic products is of concern for three principal reasons: (i) the use of cosmetic products could represent a possible source of population-wide exposure daily, and often long-term exposure to metals in cosmetic products (ii) metals can accumulate in the body over time, and (iii) a number of them are known to exhibit different chronic health effects, such as cancer, contact dermatitis, developmental, neurological and reproductive disorders, brittle hair and hair loss. Some metals are potent endocrine disruptors and respiratory toxins. Moreover, some metals, such as Cd, As, Pb, Hg and Sb, are exceptionally toxic with a wide variety of chronic health effects, whereas Cr, Ni and Co are well known skin sensitizers. Since the issue of heavy metals as deliberate cosmetic ingredients has been addressed, attention is turned to the presence of these substances as impurities.

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Heavy metal contamination of prenatal vitamins

Cited by 29 publications

References 62 publications

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence

In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

Heavy Metals: The Notorious Daredevils of Daily Personal Care Products- Mini Review

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