Heavy metal co-resistance with antibiotics amongst bacteria isolates from an open dumpsite soil

Edet, U. O.; Bassey, I. U.; Joseph, Akaninyene

doi:10.1016/j.heliyon.2023.e13457

Cited by 18 publications

(9 citation statements)

References 42 publications

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“…Our studies clearly show that most metal-tolerant microorganisms also have resistance to a wide range of antibiotics of various groups. Our results are confirmed by a significant amount of data from the literature [37][38][39][40][41][42]. Heavy metal co-resistance with antibiotics appears to be synergistic in bacterial isolates via similar mechanisms [39].…”

Section: Discussionsupporting

confidence: 84%

Antibiotic Resistance in Metal-Tolerant Microorganisms from Treatment Facilities

Perelomov,

Sizova,

Gertsen

et al. 2023

Antibiotics

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The study examines the antibiotic resistance of metal-tolerant bacteria isolated from the wastewater treatment plant of a large city to six antibiotics belonging to the β-lactam antibiotics, aminoglycosides and amphenicols. Resistance of bacteria from sewage sludge multitolerant to heavy metals to 18 antibiotics of the β-lactam antibiotics, tetracyclines, aminoglycosides, diaminopyrimidines, amphenicols and ansamycins was studied also. Out of 10, the metal-tolerant microorganisms isolated from wastewater treatment facilities only the Klebsiella pneumonia strain (tolerant to 3 mM Cu) from the sludge of a secondary settling tank did not show resistance to the studied antibiotics at the concentrations considered. Resistance to the maximum amount of antibiotics was typical for strains Serratia fonticola SS0-1, isolated from fresh sewage sludge and resistant to 5 mmol Cu and 3 mmol Pb, or Stenotrophomonas maltophilia SS0-5, also isolated from fresh sludge and resistant to 3 mmol Zn and Cu. It is possible that bacterial resistance to antibiotics develops not only as a result of the use of antibiotics themselves, but also as a result of environmental pollution with heavy metals, and vice versa.

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Section: Discussionsupporting

confidence: 84%

Antibiotic Resistance in Metal-Tolerant Microorganisms from Treatment Facilities

Perelomov,

Sizova,

Gertsen

et al. 2023

Antibiotics

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“…However, their susceptibility to soil-borne microorganisms can vary depending on factors such as microbial species, environmental conditions and antibiotic concentrations (Lazcano et al, 2021). The distribution of antibiotic resistance among the isolates in this study is similar to the study of Edet et al (2023) in which the majority of the isolates were highly resistant to selected classes of antibiotics used such as cefixime, ceftazidime, cloxacilin and cefuroxime. This study showed that Pseudomonas aeruginosa and Escherichia coli are highly resistant to cefuroxime.…”

Section: Discussionsupporting

confidence: 70%

Antibiotic Susceptibility Profile of Soil-Borne Microorganisms Isolated from Selected Dump-sites in Ogbomoso, Oyo State

Ishola,

Lawal,

Ishola

2024

dujopas

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Due to the lack of a leachate collection mechanism at most dump-sites waste is known to be a source of soil pathogens. This study aimed to detect microorganisms in dump-site soils coupled with testing the susceptibility of the detected microorganisms to selected antibiotics Soil samples were collected from five separate dump-sites in Ogbomoso, Oyo State, Nigeria. From the soil samples that were collected, eight species of bacteria and eight species of fungi were isolated. The bacterial and fungal derived from the collected soil samples were tested for antibiotic susceptibility using the conventional disc diffusion method. Results obtained indicate that the microbial loads varied between 1.7 and 4.8 x 105 CFU/g for fungal isolates while it varied from 1.0 to 8.0 x 105 CFU/g for bacterial population. Fungal isolates;Alternaria alternata, Candida albicans, Rhodotorula minuta, Fusariun oxysporum, Aspergillus flavus, Aspergillus tamarii, Fusarium solani and Penicillium digitatum were detected while bacterial isolates; Bacillus subtilis, Bacillus cereus, Staphylococcus epidermis, Clostridium sp., Acetobacter sp., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were equally detected from the dump-sites’ soil samples. The bacterial species tested were completely resistant to cefuroxime, but completely susceptible to gentamicin and ofloxacin. At varying doses, the fungal isolates demonstrated resistance to and susceptibility to griseofulvin, itraconazole, and ketoconazole.Based on the results of this study, antibiotics such as gentamicin and oflaxacin should be considered first line of defense against infections caused by both soil-borne Gram-positive and Gramnegative bacteria

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“…Furthermore, genome analysis has revealed MdtABC efflux pumps of zinc; CzcA, CzcB, and CzcC proteins causing efflux of zinc, cadmium, and cobalt; and ArsC, arsenite reductase, mercury reductase, and other arsenite and mercury transporter proteins conferring arsenic and mercury resistance ( Yu et al., 2018 ). This metal resistance, combined with the extreme antibiotic resistance that S. maltophilia displays, makes this pathogen extremely difficult to kill ( Edet et al., 2023 ).…”

Section: Metal Resistancementioning

confidence: 99%

A guide to Stenotrophomonas maltophilia virulence capabilities, as we currently understand them

Bhaumik,

Aungkur,

Anderson

2024

Front. Cell. Infect. Microbiol.

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The Gram-negative pathogen Stenotrophomonas maltophilia causes a wide range of human infections. It causes particularly serious lung infections in individuals with cystic fibrosis, leading to high mortality rates. This pathogen is resistant to most known antibiotics and harbors a plethora of virulence factors, including lytic enzymes and serine proteases, that cause acute infection in host organisms. S. maltophilia also establishes chronic infections through biofilm formation. The biofilm environment protects the bacteria from external threats and harsh conditions and is therefore vital for the long-term pathogenesis of the microbe. While studies have identified several genes that mediate S. maltophilia’s initial colonization and biofilm formation, the cascade of events initiated by these factors is poorly understood. Consequently, understanding these and other virulence factors can yield exciting new targets for novel therapeutics.

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Heavy metal co-resistance with antibiotics amongst bacteria isolates from an open dumpsite soil

Cited by 18 publications

References 42 publications

Antibiotic Resistance in Metal-Tolerant Microorganisms from Treatment Facilities

Antibiotic Resistance in Metal-Tolerant Microorganisms from Treatment Facilities

Antibiotic Susceptibility Profile of Soil-Borne Microorganisms Isolated from Selected Dump-sites in Ogbomoso, Oyo State

A guide to Stenotrophomonas maltophilia virulence capabilities, as we currently understand them

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