Heavy metal and metalloid - induced reproductive toxicity

Mukherjee, Anirban Goutam; Wanjari, Uddesh Ramesh; Renu, Kaviyarasi; Vellingiri, Balachandar; Gopalakrishnan, Abilash Valsala

doi:10.1016/j.etap.2022.103859

Cited by 54 publications

(14 citation statements)

References 158 publications

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“…The effect of Hg on ROS generation was proclaimed also by Arabi [ 48 ]. Moreover, Mukherjee et al [ 49 ] describe Hg as an initiator of numerous spermatozoa alterations, including decreased sperm count, higher incidence of morphologically defective spermatozoa, and an increased ROS level and LPO. An elevated concentration of Ni in bull semen may be accompanied by pathological modifications of spermatozoa morphology [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, despite the concentration of 2.50 mg/kg detected in the present work, no association was determined by performed correlation analysis. Zinc is crucial for male reproduction and its deficiency may lead to deteriorating alterations in spermatogenesis [ 29 , 49 ]. Janicki and Cygan-Szczegielniak [ 52 ] describe the positive association of seminal Zn with total and progressive motility in bulls.…”

Section: Discussionmentioning

confidence: 99%

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Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

et al. 2022

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This study monitored the chemical and biochemical composition of bovine seminal plasma (SP). Freshly ejaculated semen (n = 20) was aliquoted into two parts. The first aliquot was immediately assessed to determine the sperm motion parameters. Another motility measurement was performed following an hour-long co-incubation of spermatozoa with SP at 6 °C. The other aliquot was processed to obtain the SP. Seminal plasma underwent the analyses of chemical composition and quantification of selected proteins, lipids and RedOx markers. Determined concentrations of observed parameters served as input data to correlation analyses where associations between micro and macro elements and RedOx markers were observed. Significant correlations of total oxidant status were found with the content of Cu and Mg. Further significant correlations of glutathione peroxidase were detected in relation to Fe and Hg. Furthermore, associations of chemical elements and RedOx markers and spermatozoa quality parameters were monitored. The most notable correlations indicate beneficial effects of seminal Fe on motility and Mg on velocity and viability of spermatozoa. On the contrary, negative correlations were registered between Zn and sperm velocity and seminal cholesterol content and motility. Our findings imply that seminal plasma has a prospective to be developed as the potential biomarker of bull reproductive health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

et al. 2022

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“…Heavy metals and metalloids are potentially toxic to humans and animals, being able to cause deleterious effects even at low doses [ 1 , 2 ]. These toxic trace elements (TTE) are common in the soil, water, atmosphere, and food.…”

Section: Toxic Trace Elements and Cardiotoxicitymentioning

confidence: 99%

Misuse of Cardiac Lipid upon Exposure to Toxic Trace Elements—A Focused Review

et al. 2022

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Heavy metals and metalloids like cadmium, arsenic, mercury, and lead are frequently found in the soil, water, food, and atmosphere; trace amounts can cause serious health issues to the human organism. These toxic trace elements (TTE) affect almost all the organs, mainly the heart, kidney, liver, lungs, and the nervous system, through increased free radical formation, DNA damage, lipid peroxidation, and protein sulfhydryl depletion. This work aims to advance our understanding of the mechanisms behind lipid accumulation via increased free fatty acid levels in circulation due to TTEs. The increased lipid level in the myocardium worsens the heart function. This dysregulation of the lipid metabolism leads to damage in the structure of the myocardium, inclusive fibrosis in cardiac tissue, myocyte apoptosis, and decreased contractility due to mitochondrial dysfunction. Additionally, it is discussed herein how exposure to cadmium decreases the heart rate, contractile tension, the conductivity of the atrioventricular node, and coronary flow rate. Arsenic may induce atherosclerosis by increasing platelet aggregation and reducing fibrinolysis, as exposure interferes with apolipoprotein (Apo) levels, resulting in the rise of the Apo-B/Apo-A1 ratio and an elevated risk of acute cardiovascular events. Concerning mercury and lead, these toxicants can cause hypertension, myocardial infarction, and carotid atherosclerosis, in association with the generation of free radicals and oxidative stress. This review offers a complete overview of the critical factors and biomarkers of lipid and TTE-induced cardiotoxicity useful for developing future protective interventions.

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“…Exposure to heavy metals (HMs) is well-known to have significant impacts on human health [ 10 ]. Besides the conventional effects, HMs have also been confirmed to induce reproductive toxicity that ensues in endometriosis, infertility, and abortion among women [ 11 ]. Previous studies have reported that active smoking might result in HM accumulation in the human body [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Passive Smoking Is Associated with Multiple Heavy Metal Concentrations among Housewives in Shanxi Province, China

Chen

et al. 2022

IJERPH

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Background: Passive smoking may increase the content of heavy metals in housewives. However, this association remains a subject of debate. Female passive smoking is widespread, particularly in Chinese rural areas. Objective: This study aimed to assess the association between heavy metal accumulation and passive smoking status among rural housewives. Methods: 405 women were recruited in Shanxi Province of Northern China, and 384 (94.8%, 384/405) participants were included in the final study, of whom 117 women were exposed to passive smoking. The information on their basic characteristics was collected via a structured questionnaire. We used inductively coupled plasma mass spectrometry (ICP-MS) to analyze the concentrations of nine heavy metals, including cadmium (Cd), germanium (Ge), arsenic (As), lead (Pb), titanium (Ti), copper (Cu), iron (Fe), cobalt (Co), and chromium (Cr), in hair samples. Results: The results indicated that higher As, Ge, Ti, and Fe concentrations were significantly associated with passive smoking. After adjusting for potential confounders, the adjusted odds ratios and the 95% confidence intervals of As, Ge, Ti, and Fe were (1.80 (1.13–2.90),p = 0.028), (1.78 (1.14–2.80), p = 0.007), (1.70 (1.09–2.67), p = 0.019), and (1.67 (1.07–2.63), p = 0.035), respectively. The statistically significant linear trend of the adjusted odds ratios at different levels further supported their association. Conclusion: Our research concluded that exposure to environmental tobacco smoke might contribute to As, Ge, Ti, and Fe accumulation among housewives.

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Heavy metal and metalloid - induced reproductive toxicity

Cited by 54 publications

References 158 publications

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

Misuse of Cardiac Lipid upon Exposure to Toxic Trace Elements—A Focused Review

Passive Smoking Is Associated with Multiple Heavy Metal Concentrations among Housewives in Shanxi Province, China

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