Heavy metal and disinfectant resistance genes among livestock-associated methicillin-resistant Staphylococcus aureus isolates

Argudín, M. Ángeles; Lauzat, B.; Kraushaar, Britta; Alba, Patricia; Agersø, Yvonne; Cavaco, Lina; Butaye, Patrick; Porrero, M. Concepción; Battisti, Antonio; Tenhagen, Bernd‐Alois; Fetsch, A.; Guerra, Beatriz

doi:10.1016/j.vetmic.2016.06.004

Cited by 57 publications

(42 citation statements)

References 36 publications

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“…Resistance to these compounds is often associated to resistance to antimicrobial drugs such as methicillin in staphylococci, or macrolides and glycopeptides in enterococci [16]. It has been shown that these metal resistance genes are frequent in animal-associated bacteria [16,17,18,19]. The use of antimicrobials, biocides and metal compounds in animal productions in sub-therapeutic doses and with long exposure periods, may promote that bacteria fix genes that confer AMR [6,10].…”

Section: Use Of Antimicrobials In Animal Healthmentioning

confidence: 99%

“…However, animals are considered the main reservoir of the specific S. aureus lineage CC398, which has been the subject of numerous studies during recent years [18,19,82,138,139,140,141,142,143]. Studies based on the phylogenetic analysis of genome-wide single nucleotide polymorphisms (SNPs) supported the existence of two subpopulations in CC398: an ancestral human-adapted clade and an animal-associated clade [144,145].…”

Section: Amr-genes In Gram-positive Bacteria From Animalsmentioning

confidence: 99%

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Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

et al. 2017

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Antimicrobial agents are used in both veterinary and human medicine. The intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. This review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of antimicrobial resistance genes for human bacteria. This review focused in relevant examples within the ESC(K)APE (Enterococcus faecium, Staphylococcus aureus, Clostridium difficile (Klebsiella pneumoniae), Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae) group of bacterial pathogens that are the leading cause of nosocomial infections throughout the world.

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Section: Use Of Antimicrobials In Animal Healthmentioning

confidence: 99%

Section: Amr-genes In Gram-positive Bacteria From Animalsmentioning

confidence: 99%

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

et al. 2017

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“…Several resistance genes encoding enzyme synthesis responsible for resistance towards metallic as well as non-metallic compounds used in AMCs have been described [59,60]. The resistance genes may occur in bacterial chromosome or in plasmids and can be transmitted to other microbes via horizontal gene transfer similarly with antibiotic resistance genes [60].…”

Section: Resultsmentioning

confidence: 99%

Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI

Ahonen

Kahru

Ivask

et al. 2017

IJERPH

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Infections and infectious diseases are considered a major challenge to human health in healthcare units worldwide. This opinion paper was initiated by EU COST Action network AMiCI (AntiMicrobial Coating Innovations) and focuses on scientific information essential for weighing the risks and benefits of antimicrobial surfaces in healthcare settings. Particular attention is drawn on nanomaterial-based antimicrobial surfaces in frequently-touched areas in healthcare settings and the potential of these nano-enabled coatings to induce (eco)toxicological hazard and antimicrobial resistance. Possibilities to minimize those risks e.g., at the level of safe-by-design are demonstrated.

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“…Also, czrC rarely coexists with other heavy metal resistance determinants on the same SCC element although a strong association with multiple antimicrobial resistance genes can be observed (Argudín et al, ) . In fact, this gene has attracted attention as it may be responsible for the frequent zinc resistance among methicillin‐resistant CC398 S. aureus strains (Argudín et al, ; Cavaco et al, , ; Monecke et al, ; Nair, Thapaliya, Su, & Smith, ).…”

Section: Cadmium and Arsenic Resistance In Staphylococcus Sppmentioning

confidence: 99%

“…Resistance to heavy metals used as antimicrobials in human and veterinary medicine (arsenic, copper, mercury, and zinc) has been frequently reported for S. aureus and other species of the genus were harbored both on plasmids and chromosomally on staphylococcal cassette chromosome (SCC) elements (Argudín et al, 2016;Das et al, 2016;Lanza et al, 2015). In several cases, operons mediating resistance to different heavy metals cooccurred with genes involved in resistance to antibiotics and biocides, suggesting coselection of heavy metal resistance and other environmental adaptations (Argudín et al, 2019;Baker-Austin, Wright, Stepanauskas, & McArthur, 2006;Das et al, 2016;Lanza et al, 2015;Wales & Davies, 2015).…”

Section: Admi Um and Ar S Eni C Re S Is Tan Ce In S Taphylococcusmentioning

confidence: 99%

Dissemination and conservation of cadmium and arsenic resistance determinants in Listeria and other Gram‐positive bacteria

Parsons

Lee

Kathariou

2020

Molecular Microbiology

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Metal homeostasis in bacteria is a complex and delicate balance. While some metals such as iron and copper are essential for cellular functions, others such as cadmium and arsenic are inherently cytotoxic. While bacteria regularly encounter essential metals, exposure to high levels of toxic metals such as cadmium and arsenic is only experienced in a handful of special habitats. Nonetheless, Listeria and other Gram‐positive bacteria have evolved an impressively diverse array of genetic tools for acquiring enhanced tolerance to such metals. Here, we summarize this fascinating collection of resistance determinants in Listeria, with special focus on resistance to cadmium and arsenic, as well as to biocides and antibiotics. We also provide a comparative description of such resistance determinants and adaptations in other Gram‐positive bacteria. The complex coselection of heavy metal resistance and other types of resistance seems to be universal across the Gram‐positive bacteria, while the type of coselected traits reflects the lifestyle of the specific microbe. The roles of heavy metal resistance genes in environmental adaptation and virulence appear to vary by genus, highlighting the need for further functional studies to explain the mystery behind the array of heavy metal resistance determinants dispersed and maintained among Gram‐positive bacteria.

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Heavy metal and disinfectant resistance genes among livestock-associated methicillin-resistant Staphylococcus aureus isolates

Cited by 57 publications

References 36 publications

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI

Dissemination and conservation of cadmium and arsenic resistance determinants in Listeria and other Gram‐positive bacteria

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