Heavy ion synchrotron for medical use —HIMAC project at NIRS-Japan—

Hirao, Y.; Ogawa, H.; Yamada, S.; Satô, Yukio; Yamada, Takanobu; Satô, Kenji; Itano, A.; Kanazawa, M.; Noda, K.; Kawachi, Kiyomitsu; Endo, Masahiro; Kanai, Tatsuaki; Kohno, Toshiyuki; Sudou, Michio; Minohara, S.; Kitagawa, A.; Soga, F.; Takada, E.; Watanabe, Shin; Endo, K.; Kumada, М.; Matsumoto, Shûji

doi:10.1016/0375-9474(92)90803-r

Cited by 286 publications

(87 citation statements)

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“…Design studies began in 1984, and the construction of a heavy-ion synchrotron designated as Heavy Ion Medical Accelerator in Chiba (HIMAC) (Fig. 7), began in 1987 with the appointment of Yasuo Hirao from the Institute for Nuclear Study, University of Tokyo, as the project leader [10]. The HIMAC was completed in 1993.…”

Section: Himac At Nirsmentioning

confidence: 99%

Robert R. Wilson (1914–2000): the first scientist to propose particle therapy—use of particle beam for cancer treatment

Endo

2017

Radiol Phys Technol

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Section: Himac At Nirsmentioning

confidence: 99%

Robert R. Wilson (1914–2000): the first scientist to propose particle therapy—use of particle beam for cancer treatment

Endo

2017

Radiol Phys Technol

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“…As an initial example of the internal device concept, a spectrum of eight proton groups (i.e., 10,20,30,40,50,60,70, and 80 MeV) is selected to be the output of the device. A spectrum of energies facilitates the irradiation of the entire tumor volume.…”

Section: Absorbed Dose Calculationsmentioning

confidence: 99%

“…Each device is assumed to radiate isotropically. The results of irradiating this water volume with 27 internal devices generating an output of 10,20,30,40,50,60,70, and 80 MeV protons are illustrated in Figure 1. The luence at each proton energy is selected to be the same.…”

Section: Absorbed Dose Calculationsmentioning

confidence: 99%

Radiotherapy Dose Optimization in Target Tissues Using Internal Radiation-Generating Devices and Microspheres

Bevelacqua¹

2017

Radiotherapy

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Preferentially delivering ionizing radiation to target tissues during radiotherapy procedures is investigated using internal radiation-generating devices and microspheres loaded with radioactive material. This chapter presumes the existence of internal radiation-generating devices and develops their requisite characteristics to permit the selective irradiation of tumors. The feasibility of disrupting a tumor's vascular structure is also investigated. Calculated absorbed dose proiles for both approaches demonstrate that dose can be successfully localized in a target tissue while minimizing the delivery to healthy tissue.

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“…The National Institute of Radiological Sciences (NIRS), therefore, decided to construct the "Heavy-ion Medical Accelerator in Chiba" (HIMAC). 1 The construction of HIMAC was completed in October 1993 as the world's first heavyion accelerator facility dedicated to medical applications. After a pre-clinical study, NIRS has conducted the HIMAC radiotherapy since 1994.…”

Section: Introductionmentioning

confidence: 99%

Development of heavy-ion radiotherapy technology with HIMAC

Noda¹

2016

Int. J. Mod. Phys. Conf. Ser.

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Since 1994, HIMAC has carried out clinical studies and treatments for more than 9000 cancer patients with carbon-ion beams. During the first decade of the HIMAC study, a single beamwobbling method, adopted as the HIMAC beam-delivery technique, was improved for treatments of moving tumors and for obtaining more conformal dose distribution. During the second decade, a pencil-beam 3D scanning method has been developed toward an "adaptive cancer treatment" for treatments of both static and moving tumors. A new treatment research facility was constructed with HIMAC in order to verify the developed 3D scanning technology through a clinical study that has been successfully conducted since 2011. As the next stage, a compact heavy-ion rotating gantry with a superconducting technology has been developed for the more accurate and shortercourse treatments. The twenty-year development of the heavy-ion radiotherapy technologies including accelerator technologies with HIMAC is reviewed.

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Heavy ion synchrotron for medical use —HIMAC project at NIRS-Japan—

Cited by 286 publications

References 0 publications

Robert R. Wilson (1914–2000): the first scientist to propose particle therapy—use of particle beam for cancer treatment

Robert R. Wilson (1914–2000): the first scientist to propose particle therapy—use of particle beam for cancer treatment

Radiotherapy Dose Optimization in Target Tissues Using Internal Radiation-Generating Devices and Microspheres

Development of heavy-ion radiotherapy technology with HIMAC

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