Heavy Ion Effects on Yeast Cells: Reappearance of the Oxygen Effect with Very High LET

Schöpfer, Francisco J.; Schneider, Elisabeth; Rase, S.; Kiefer, Jürgen; Kraft, Gerhard; Liesem, H.

doi:10.1080/09553008414551441

Cited by 11 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is quite certain that the production of oxygen in the tracks of highly charged particles can have significant biological consequences. 28,29 The maximum yield of excess molecular oxygen is determined to be about 0.6 for highly charged particles. Previous measurements reported a yield of 0.5 for the production of HO 2 with nickel ions.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Radiolysis of the Fricke Dosimeter with ⁵⁸Ni and ²³⁸U Ions: Response for Particles of High Linear Energy Transfer

LaVerne

Schüler

1996

J. Phys. Chem.

View full text Add to dashboard Cite

The radiation chemical yields of the Fricke dosimeter have been determined for incident nickel and uranium ions with energies of up to 470 and 3780 MeV, respectively. Track segment yields have been determined from the observed energy dependences. Experiments utilizing both aerated and deaerated solutions indicate that at the very high values of linear energy transfer (LET) exhibited by these ions in water (a maximum of 5000 and 17 000 eV/nm, respectively) a significant fraction of radicals escape from the track. The radiation chemical yield of H atoms for both ions is found to be ∼10% of the value with fast electrons. The data also suggest that there is a substantial yield of an oxidizing species produced by particles of very high LET. A comparison of the results with particles of lower LET is made.

show abstract

Section: Resultsmentioning

confidence: 99%

“… Of course, the material balance does not specify the source of molecular oxygen, and the literature is not very clear either. It is quite certain that the production of oxygen in the tracks of highly charged particles can have significant biological consequences. , …”

Section: Resultsmentioning

confidence: 99%

Radiolysis of the Fricke Dosimeter with ⁵⁸Ni and ²³⁸U Ions: Response for Particles of High Linear Energy Transfer

LaVerne

Schüler

1996

J. Phys. Chem.

View full text Add to dashboard Cite

show abstract

“…This unique relationship breaks down, however, with very heavy ions. Studies with different yeast strains show that the oxygen effect reappears with heavy ions of sufficient energy (Sch6pfer et al 1984) although both l.e.t. and Z* 2 /3 2 are very high.…”

Section: Cell Inactivationmentioning

confidence: 95%

“…decreases with increasing l.e.t. (for references see Sch6pfer et al 1984) and approaches unity around 100 keV/pm. The data can be fitted to a common curve if a normalized o.e.r.…”

Section: Cell Inactivationmentioning

confidence: 98%

See 1 more Smart Citation

Cellular and Subcellular Effects of Very Heavy Ions

Kiefer

1985

International Journal of Radiation Biology and Related Studies

View full text Add to dashboard Cite

The biological effects of irradiation with ions of masses larger than 40 and energies up to 20 MeV per atomic mass unit are reviewed. The objects are viruses, bacterial spores, yeast and mammalian cells. Experimental parameters include loss of colony forming ability, induction of mutants, chromosomal aberrations, cell cycle progression, inhibition of biochemical activities and the formation of strand breaks. Some of the pertinent physical questions--e.g. track structure--are also discussed. It is shown that with very heavy ions the biological effectiveness is no longer unambiguously related to a single parameter like l.e.t. or Z*2/beta 2 but depends strongly on ion energy. This points to the importance of far-reaching delta-electrons. The analysis indicates also that even with very high l.e.t., cells are not killed by the passage of a single particle through their nucleus. Possible implications of the findings for fundamental radiation biology are outlined.

show abstract

Space Microbiology: Effects of Ionizing Radiation on Microorganisms in Space

Horneck

Baumstark‐Khan

Reitz

2003

Encyclopedia of Environmental Microbiology

View full text Add to dashboard Cite

Biological Weighting of Radiation Environmental Radiation and Life Terrestrial Radiation Environment The Radiation Environment of Space Effects of Cosmic Radiation on Microorganisms Responses to Combined Action of Space Radiation and Microgravity Chances of Interplanetary Transfer of Life Environmental Radiation and Putative Habitats on Mars

show abstract

Heavy Ion Effects on Yeast Cells: Reappearance of the Oxygen Effect with Very High LET

Cited by 11 publications

References 14 publications

Radiolysis of the Fricke Dosimeter with ⁵⁸Ni and ²³⁸U Ions: Response for Particles of High Linear Energy Transfer

Radiolysis of the Fricke Dosimeter with ⁵⁸Ni and ²³⁸U Ions: Response for Particles of High Linear Energy Transfer

Cellular and Subcellular Effects of Very Heavy Ions

Space Microbiology: Effects of Ionizing Radiation on Microorganisms in Space

Contact Info

Product

Resources

About

Heavy Ion Effects on Yeast Cells: Reappearance of the Oxygen Effect with Very High LET

Cited by 11 publications

References 14 publications

Radiolysis of the Fricke Dosimeter with 58Ni and 238U Ions: Response for Particles of High Linear Energy Transfer

Radiolysis of the Fricke Dosimeter with 58Ni and 238U Ions: Response for Particles of High Linear Energy Transfer

Cellular and Subcellular Effects of Very Heavy Ions

Space Microbiology: Effects of Ionizing Radiation on Microorganisms in Space

Contact Info

Product

Resources

About

Radiolysis of the Fricke Dosimeter with ⁵⁸Ni and ²³⁸U Ions: Response for Particles of High Linear Energy Transfer

Radiolysis of the Fricke Dosimeter with ⁵⁸Ni and ²³⁸U Ions: Response for Particles of High Linear Energy Transfer