Heavy Alcohol Consumption is Associated with Impaired Endothelial Function:

Tanaka, Atsunori; Cui, Renzhe; Kitamura, Akihiko; Liu, Keyang; Imano, Hironori; Yamagishi, Kazumasa; Kiyama, Masahiko; Okada, Takeo; Iso, Hiroyasu

doi:10.5551/jat.31641

Cited by 48 publications

(39 citation statements)

References 31 publications

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“…Endothelial function and low-grade vascular inflammation are associated with dietary intake including alcohol [33] . Red wine consumption has been reported to cause less endothelial dysfunction and reduce inflammation in vasculature [34] while other studies found that heavy or even light alcohol consumption were associated with impaired endothelial function [35][36] . The relationship between the alcohol and endothelia is complicated, which may involve the type and amount of alcohol consumed, the age and race of the drinker, and many other factors.…”

Section: Discussionmentioning

confidence: 98%

The Natural Course of Hereditary Angioedema in a Chinese Cohort

Cao

Liu

Zhi³

2020

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Background Hereditary angioedema (HAE) is a rare disease with potential life-threatening risks. Until now, few studies have focused on the natural course of HAE, which is essential for practitioners and patients to predict disease progression and avoid possible risk factors. Objectives Describe the natural course of HAE and explore possible risk factors, providing new clues for guiding clinical prevention and treatment. Methods A web-based survey was conducted in 103 Chinese patients with type 1 HAE. Disease progression under therapy-free conditions was collected at different age stages. The demographic characteristics, lifestyles, disease severity and family history were also provided by each participant. Results Among 103 patients, 14 (13.6%) had their first HAE attack before ten years old and 51 (49.5%) between 10 and 19. The disease worsened in 83.3% of the patients in their twenties. The proportion of patients with symptoms alleviated increased after the age of 30 years old, but the disease maintained relatively severe in most cases before 50. The participants also reported 233 members shared similar symptoms of angioedema in their family and 30 had died of laryngeal edema with the median death age of 46 years old. The disease severity was not observed to be affected significantly by gender, BMI, alcohol or smoking. Conclusions We summarized HAE progression patterns in therapy-free conditions, showing the natural course of disease development along with aging. Long-term prophylaxis and symptomatic treatment are recommended for all HAE patients, especially young and middle-aged and might be adjusted depending on the disease progression.

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Section: Discussionmentioning

confidence: 98%

The Natural Course of Hereditary Angioedema in a Chinese Cohort

Cao

Liu

Zhi³

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Endothelial function and low-grade vascular in ammation are associated with dietary intake including alcohol [35] . Red wine consumption has been reported to cause less endothelial dysfunction and reduce in ammation in vasculature [36] while other studies found that heavy or even light alcohol consumption were associated with impaired endothelial function [37][38] . The relationship between the alcohol and endothelia is complicated, which may involve the type and amount of alcohol consumed, the age and race of the drinker, and many other factors.…”

Section: Discussionmentioning

confidence: 98%

The Natural Course of Hereditary Angioedema in a Chinese Cohort

Cao

Liu

Zhi³

2020

Preprint

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Background: Hereditary angioedema (HAE) is a rare disease with potential life-threatening risks. To study the natural course of HAE under therapy-free conditions throughout patient life is essential for practitioners and patients to avoid possible risk factors and guide treatment.Objectives: Describe the natural course of HAE and explore possible risk factors, providing new clues for guiding clinical prevention and treatment.Methods: A web-based survey was conducted in 103 Chinese patients with type 1 HAE. Disease progression at different age stages was provided by each participant. The data for exploring the natural course of HAE composed of two parts: one came from the participants who had never adopted any prophylactic drug for HAE; the other was from the patients with a history of medication, but only the periods before they got confirmed diagnosis and received medications were analyzed. The demographic characteristics, lifestyles, disease severity, and family history were also collected.Results: Among 103 patients, 14 (13.6%) had their first HAE attack before ten years old and 51 (49.5%) between 10 and 19. The disease worsened in 83.3% of the patients in their twenties. The proportion of patients with symptoms alleviated increased after the age of 30 years old, but the disease maintained relatively severe in most cases before 50. The participants also reported 233 members shared similar symptoms of angioedema in their family and 30 had died of laryngeal edema with the median death age of 46 years old. The disease severity was not observed to be affected significantly by gender, BMI, alcohol or smoking.Conclusions: We summarized HAE progression patterns under therapy-free conditions, showing the natural course of HAE development along with aging. Long-term prophylaxis and symptomatic treatment are recommended for all HAE patients, especially young and middle-aged and might be adjusted depending on the disease progression.

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“…Indeed, in south of China, although a traditional dinner party generally tends to consume all kinds of alcoholic beverage and plenty of meat, no previous data revealed the effect of alcohol and meat on RHI-measured micro-vascular ED. However, several studies that used the FMD index to evaluate the alcohol effect were controversial: chronic moderate to heavy alcohol consumption caused macro-vascular endothelial dysfunction in Asian men 34,35 , and even FMD was signi cantly smaller in light alcohol drinkers 36 . Conversely, the consumption of moderate and high alcoholic beverages was independently associated with better FMD, when compared to no alcohol consumption 37,38 , especially when consuming red wine 39 .…”

Section: Discussionmentioning

confidence: 99%

A Novel Use of Structural Equation Modeling to Examine Life-style and Cardio-metabolic Factors Associated With Micro-vascular Endothelial Dysfunction in Middle-aged Chinese Males

Miao

Zhou

et al. 2020

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Objective: The present study aims to use structural equation modeling with multiple regression pathways to examine direct and indirect association of potential behavioral (diet, physical activity and sleep) and cardio-metabolic risk factors with micro-vascular endothelial dysfunction (ED) among middle-aged Chinese males.Methods: The study was conducted in 306 middle-aged Chinese males, who underwent a health checkup between 2018 and 2019. Data on life-style behavior factors (physical activity, diet pattern, sleep quality, and diet data underwent exploratory and confirmatory factor analysis [EFA and CFA] in advance) and cardio-metabolic risk factors referring to metabolic syndrome [blood pressure, triglyceride (TG), fasting blood glucose, high-density lipoprotein cholesterol and body mass index] were introduced into the structural equation model to examine interrelationship among these factors and their association with ED, as evaluated by the reactive hyperemia index (RHI). Results: Impaired ED defined by RHI <1.67 occurred in 39.2% of the participants. Both EFA and CFA identified two major dietary patterns: "prudent pattern" and "western pattern". The univariate test suggested that only TG and prudent dietary pattern were directly associated with RHI. Furthermore, prudent dietary pattern had a direct association with RHI (β=0.16, P<0.05) and an indirect association via triglyceride (Prudent diet→TG: β=-0.15, P<0.05; TG→RHI: β=-0.17, P<0.001). As to confirming the hypothesized association between variables apart, physical activity frequency was correlated to the decrease in TG (β=-0.29, P<0.001), but had no direct correlation to RHI.Conclusion: The network of direct and indirect associations among life-style behavioral and cardio-metabolic risk factors with RHI measured ED among middle-aged males. The most significant modifiable factors identified were TG and prudent diet pattern, which needs to be targeted as preventive strategies for early micro-vascular impairment.

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Heavy Alcohol Consumption is Associated with Impaired Endothelial Function:

Cited by 48 publications

References 31 publications

The Natural Course of Hereditary Angioedema in a Chinese Cohort

The Natural Course of Hereditary Angioedema in a Chinese Cohort

The Natural Course of Hereditary Angioedema in a Chinese Cohort

A Novel Use of Structural Equation Modeling to Examine Life-style and Cardio-metabolic Factors Associated With Micro-vascular Endothelial Dysfunction in Middle-aged Chinese Males

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