Heating patterns of the Helios ultrasound hyperthermia system

Lindsley, Karen; Stauffer, Paul R.; Sneed, Penny K.; Chin, Ronny B.; Phillips, Theodore L.; Seppi, E.; Shapiro, Edward G.; Henderson, S.

doi:10.3109/02656739309032055

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…In the early and mid-1980s, a dozen or more companies were established to manufacture hyperthermia equipment for clinical use. Some larger companies, such as Varian, were briefly invested in the idea as well [45,46]. However, the perceived difficulties of achieving what was considered therapeutically effective temperatures, combined with technical difficulties of performing hyperthermia in general and lack of adequate reimbursement led to loss of commercial interest in the technology [7].…”

Section: Effects On Equipment Design Criteriamentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

282

199

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This review takes a retrospective look at how hyperthermia biology, as defined from studies emerging from the late 1970s and into the 1980s, mis-directed the clinical field of hyperthermia, by placing too much emphasis on the necessity of killing cells with hyperthermia in order to define success. The requirement that cell killing be achieved led to sub-optimal hyperthermia fractionation goals for combinations with radiotherapy, inappropriate sequencing between radiation and hyperthermia and goals for hyperthermia equipment performance that were neither achievable nor necessary. The review then considers the importance of the biologic effects of hyperthermia that occur in the temperature range that lies between that necessary to kill substantial proportions of cells and normothermia (e.g. 39-42 degrees C for 1 h). The effects that occur in this temperature range are compelling-including inhibition of radiation-induced damage repair, changes in perfusion, re-oxygenation, effects on macromolecular and nanoparticle delivery, induction of the heat shock response and immunological stimulation, all of which can be exploited to improve tumour response to radiation and chemotherapy. This new knowledge about the biology of hyperthermia compels one to continue to move the field forward, but with thermal goals that are eminently achievable and tolerable by patients. The fact that lower temperatures are incorporated into thermal goals does not lessen the need for non-invasive thermometry or more sophisticated hyperthermia delivery systems, however. If anything, it further compels one to move the field forward on an integrated biological, engineering and clinical level.

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Section: Effects On Equipment Design Criteriamentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

282

199

View full text Add to dashboard Cite

show abstract

“…3 Over the years, ultrasound devices capable of improved heating uniformity and controlled depth of penetration, mostly by using multiple applicators with phasing and power steering, have been designed. [127][128][129][130][131][132][133]…”

Section: Ultrasoundmentioning

confidence: 99%

Thermal Therapy, Part 2: Hyperthermia Techniques

Habash

Bansal

Krewski

et al. 2006

Crit Rev Biomed Eng

189

143

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Hyperthermia, the procedure of raising the temperature of a part of or the whole body above normal for a defined period of time, is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. Clinical hyperthermia falls into three broad categories, namely, (1) localized hyperthermia, (2) regional hyperthermia, and (3) whole-body hyperthermia (WBH). Because of the various problems associated with each type of treatment, different heating techniques have evolved. In this article, background information on the biological rationale and current status of technologies concerning heating equipment for the application of hyperthermia to human cancer treatment are provided. The results of combinations of other modalities such as radiotherapy or chemotherapy with hyperthermia as a new treatment strategy are summarized. The article concludes with a discussion of challenges and opportunities for the future.

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“…2 and 3͒. The scanned focused ultrasound hyperthermia system [17][18][19][20][21] or two-dimensional phased arrays of transducers [22][23][24] can achieve this goal with a proper arrangement.…”

Section: Casementioning

confidence: 99%

“…Thus, a convolution power deposition with a convergent-divergent cone shape should be formed to provide appropriate heating. 16 Scanned, focused ultrasound heating systems [17][18][19][20][21] can produce a convolution power deposition close to this ideal shape by scanning the ultrasound beams with appropriate scan parameters. In addition, two-dimensional arrays of transducers [22][23][24] can yield such a power deposition by controlling the amplitude and phase of each array element.…”

Section: Introductionmentioning

confidence: 99%

Theoretical study of temperature elevation at muscle/bone interface during ultrasound hyperthermia

et al. 2000

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This paper examines the distributions of the SAR (specific absorption rate) ratio and temperature elevation when an ultrasound beam propagates through the interface of muscle and bone. This interface is regarded as a flat boundary to partition the energy of the ultrasound beam, and the analytical solution of temperature distribution is based on the steady-state bio-heat transfer equation. The parameters considered are the incident angle of ultrasound beam, the ultrasound frequency, the acoustic attenuation coefficients of refracted longitudinal and shear waves in bone, and the blood perfusion in muscle. The results show that the peak of the SAR ratio is always at the interface of muscle and bone, while the peak of temperature is located in the bone region beyond the interface. A muscle with lower perfusion or a bone with higher acoustic attenuation results in the shifting of the temperature peak closer to the interface. It is more difficult to heat a higher perfused muscle in front of a bone using a lower frequency ultrasound since the temperature elevation for bone relative to muscle is greater.

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Heating patterns of the Helios ultrasound hyperthermia system

Cited by 8 publications

References 10 publications

Re-setting the biologic rationale for thermal therapy

Re-setting the biologic rationale for thermal therapy

Thermal Therapy, Part 2: Hyperthermia Techniques

Theoretical study of temperature elevation at muscle/bone interface during ultrasound hyperthermia

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