Abstract:Background and objectives: Alterations of factor Vili (FVIII) during preparation
procedures can potentially affect its immunogenicity. One method evaluating
such alterations could be by determining the reactivity of FVIII with specific
antibodies. Materials and methods: Since heat treatment is currently
used to reduce the risk of viral transmission, we evaluated the immunoreactivity
of plasma-derived FVIII before and after heating at different temperatures and
for different periods. Freeze-dried FVIII was used… Show more
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