Heath State Utility Values for Cost-Effectiveness Models

Karnon, Jonathan

doi:10.1007/s40273-017-0537-x

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…21,31 However, systematic approaches to the selection and synthesis of appropriate HSUVs from the literature are poorly, if ever, applied. 32,33 A recent review of breast cancer CUAs found that the mean number of references for HSUVs was only 2 out of a large number of published health utility studies in breast cancer. 26 Similar observations are also reported for Alzheimer's disease 34 and mental disorders.…”

Section: Issues In Measuring and Using Hsuvsmentioning

confidence: 99%

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Toward a Centralized, Systematic Approach to the Identification, Appraisal, and Use of Health State Utility Values for Reimbursement Decision Making: Introducing the Health Utility Book (HUB)

et al. 2019

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Cost-utility analysis (CUA) is a widely recommended form of health economic evaluation worldwide. The outcome measure in CUA is quality-adjusted life-years (QALYs), which are calculated using health state utility values (HSUVs) and corresponding life-years. Therefore, HSUVs play a significant role in determining cost-effectiveness. Formal adoption and endorsement of CUAs by reimbursement authorities motivates methodological advancement in HSUV measurement and application. A large body of evidence exploring various methods in measuring HSUVs has accumulated, imposing challenges for investigators in identifying and applying HSUVs to CUAs. First, large variations in HSUVs between studies are often reported, and these may lead to different cost-effectiveness conclusions. Second, issues concerning the quality of studies that generate HSUVs are increasingly highlighted in the literature. This issue is compounded by the limited published guidance and methodological standards for assessing the quality of these studies. Third, reimbursement decision making is a context-specific process. Therefore, while an HSUV study may be of high quality, it is not necessarily appropriate for use in all reimbursement jurisdictions. To address these issues, by promoting a systematic approach to study identification, critical appraisal, and appropriate use, we are developing the Health Utility Book (HUB). The HUB consists of an HSUV registry, a quality assessment tool for health utility studies, and a checklist for interpreting their use in CUAs. We anticipate that the HUB will make a timely and important contribution to the rigorous conduct and proper use of health utility studies for reimbursement decision making. In this way, health care resource allocation informed by HSUVs may reflect the preferences of the public, improve health outcomes of patients, and maintain the efficiency of health care systems.

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Section: Issues In Measuring and Using Hsuvsmentioning

confidence: 99%

“…HSUV users have largely been left without guidance on such matters, as the standards published by many health technology assessment bodies rarely reference the methodological considerations and complexities of the HSUV research. 32,33 Applicability. Reimbursement decision making is a context-specific process.…”

Section: Issues In Measuring and Using Hsuvsmentioning

confidence: 99%

Toward a Centralized, Systematic Approach to the Identification, Appraisal, and Use of Health State Utility Values for Reimbursement Decision Making: Introducing the Health Utility Book (HUB)

et al. 2019

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“…This metric combines data on preferences for being in a particular health state with data on length of time in that state (1)(2)(3)(4). The application of QALYs have also been acknowledged by several organizations as recommend practice (5; 6) and they are widely accepted as a reference standard in costeffectiveness analyses (7)(8)(9)(10). For example, the National Institute for Health and Clinical Excellence (NICE) in England requires the use of QALYs for health technology assessment research (5).…”

Section: Introductionmentioning

confidence: 99%

Estimating Quality of Life Decrements Due to Diabetes Complications in the United States: The Health Utility Index (HUI) Diabetes Complication Equation

et al. 2019

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Objective-Health utility decrements associated with diabetes complications are essential for calculating quality-adjusted life years (QALYs) in patients for use in economic evaluation of diabetes interventions. Previous studies mostly focused on assessing the impact of complications on health utility at event year based on cross-sectional data. This study aimed to separately estimate health utility decrements associated with current and previous diabetes complications.Research Design and Methods-The Health Utilities Index Mark 3 (HUI-3) was used to measure heath utility in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N=8,713). Five macrovascular complications (myocardial infarction (MI), congestive heart failure (CHF), stroke, angina, and revascularization surgery (RS)) and three microvascular complications (nephropathy (renal failure), retinopathy (severe vision loss), and neuropathy (severe pressure sensation loss)) were included in a set of alternative modelling approaches including ordinary least squares (OLS) model, fixed effects model and random effects model to estimate the complicationrelated health utility decrements.

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“…They can be used to compare HRQoL with other chronic illnesses and a healthy population, which is not possible with a disease specific HRQoL ( 22 ). They can also be used to calculate quality adjusted life years (QALYs) and to determine cost-effectiveness of medical treatments ( 23 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of Superior Canal Dehiscence Syndrome on Health Utility Values: A Prospective Case-Control Study

et al. 2020

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Introduction: Superior canal dehiscence syndrome (SCDS) is a condition characterized by a defect in the bone overlying the superior semicircular canal, creating a third mobile window into the inner ear. Patients can experience disabling symptoms and opt for surgical management. Limited data are available on the impact of SCDS on health-related quality of life (HRQoL) and disease-specific HRQoL more specifically. Objective: To perform a prospective analysis on generic HRQoL in SCDS patients compared to healthy age-matched controls. Methods: A prospective study was performed on patients diagnosed with SCDS and who did not undergo reconstructive surgery yet. Patients were recruited between November 2017 and January 2020 and asked to complete the Health Utility Index (HUI) Mark 2 (HUI2)/Mark 3 (HUI3) questionnaire. For the control group, age-matched participants without otovestibular pathology or other chronic pathology were recruited. The multi-attribute utility function (MAUF) score was calculated for the HUI2 and HUI3. Results of both groups were compared using the Mann-Whitney U test. Results: A total of 20 patients completed the questionnaire. Age ranged from 37 to 79 years with a mean age of 56 years (45% males and 55% females). The control group consisted of 20 participants with a mean age of 56.4 years and ranged from 37 to 82 years (35% males and 65% females). For the case group, median HUI2 MAUF score was 0.75 and median HUI3 MAUF score was 0.65. For the control group, the median scores were 0.88 and 0.86 respectively. There was a statistically significant difference for both HUI2 ( p = 0.024) and HUI3 ( p = 0.011). SCDS patients had a worse generic HRQoL than age-matched healthy controls. One patient with unilateral SCDS had a negative HUI3 MAUF score (−0.07), indicating a health-state worse than death. Conclusion: SCDS patients have significantly lower health utility values than an age-matched control group. This confirms the negative impact of SCDS on generic HRQoL, even when using an instrument that is not designed to be disease-specific but to assess health state in general. These data can be useful to compare impact on HRQoL among diseases.

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Heath State Utility Values for Cost-Effectiveness Models

Cited by 5 publications

References 8 publications

Toward a Centralized, Systematic Approach to the Identification, Appraisal, and Use of Health State Utility Values for Reimbursement Decision Making: Introducing the Health Utility Book (HUB)

Toward a Centralized, Systematic Approach to the Identification, Appraisal, and Use of Health State Utility Values for Reimbursement Decision Making: Introducing the Health Utility Book (HUB)

Estimating Quality of Life Decrements Due to Diabetes Complications in the United States: The Health Utility Index (HUI) Diabetes Complication Equation

Impact of Superior Canal Dehiscence Syndrome on Health Utility Values: A Prospective Case-Control Study

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