Heated and Humidified High-Flow Oxygen Therapy Reduces Discomfort During Hypoxemic Respiratory Failure

Cuquemelle, E.; Pham, Tài; Papon, Jean‐François; Louis, Bruno; Danin, Pierre-Éric; Brochard, Laurent

doi:10.4187/respcare.01681

Cited by 152 publications

(103 citation statements)

References 23 publications

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“…[21][22][23] In addition, all of these mechanisms also explain why HFNC improved gas exchange and subject comfort. The advantage of HFNC in terms of improving dyspnea, subject comfort, and oxygenation has also been noted in other subject populations, such as post-cardiac surgery 8 and postendotracheal extubation subjects, 7,9 and during fiberoptic bronchoscopy.…”

Section: Discussionmentioning

confidence: 99%

Use of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department

Rittayamai¹,

Tscheikuna²,

et al. 2015

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BACKGROUND: Acute dyspnea and hypoxemia are 2 of the most common problems in the emergency room. Oxygen therapy is an essential supportive treatment to correct these issues. In this study, we investigated the physiologic effects of high-flow nasal oxygen cannula (HFNC) compared with conventional oxygen therapy (COT) in subjects with acute dyspnea and hypoxemia in the emergency room. METHODS: A prospective randomized comparative study was conducted in the emergency department of a university hospital. Forty subjects were randomized to receive HFNC or COT for 1 h. The primary outcome was level of dyspnea, and secondary outcomes included change in breathing frequency, subject comfort, adverse events, and rate of hospitalization. RESULTS: Common causes of acute dyspnea and hypoxemia were congestive heart failure, asthma exacerbation, COPD exacerbation, and pneumonia. HFNC significantly improved dyspnea (2.0 ؎ 1.8 vs 3.8 ؎ 2.3, P ‫؍‬ .01) and subject comfort (1.6 ؎ 1.7 vs 3.7 ؎ 2.4, P ‫؍‬ .01) compared with COT. No statistically significant difference in breathing frequency was found between the 2 groups at the end of the study. HFNC was well tolerated, and no serious adverse events were found. The rate of hospitalization in the HFNC group was lower than in the COT group, but there was no statistically significant difference (50% vs 65%, P ‫؍‬ .34). CONCLUSIONS: HFNC improved dyspnea and comfort in subjects presenting with acute dyspnea and hypoxemia in the emergency department. HFNC may benefit patients requiring oxygen therapy in the emergency room.

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Section: Discussionmentioning

confidence: 99%

Use of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department

Rittayamai¹,

Tscheikuna²,

et al. 2015

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“…This excellent tolerance, systematically reported with HFNC during acute hypoxemic failure, 4,15,16 is attributable, at least in part, to the heat and humidity supplied by the device. 35 We reported a case of prolonged HFNC use for over 30 d. 36 …”

Section: Comfortmentioning

confidence: 98%

Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects

et al. 2015

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INTRODUCTION: High-flow nasal cannula (HFNC) can deliver heated and humidified gas (up to 100% oxygen) at a maximum flow of 60 L/min via nasal prongs or cannula. The aim of this study was to assess the short-term physiologic effects of HFNC. Inspiratory muscle effort, gas exchange, dyspnea score, and comfort were evaluated. METHODS: Twelve subjects admitted to the ICU for acute hypoxemic respiratory failure were prospectively included.

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“…Standard oxygen through face mask provides non-humidified or under-humidified cold gas that dries the upper airway and leads to reduced patient comfort, even when a bubble humidifier is used (30). Most studies have reported better comfort and dyspnea feeling with HFNC than with standard oxygen through a mask or NIV (10,17,(31)(32)(33) with subsequently improved compliance (34).…”

Section: Comfort and Humidificationmentioning

confidence: 99%

High-flow nasal oxygen therapy and noninvasive ventilation in the management of acute hypoxemic respiratory failure

et al. 2017

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Heated and Humidified High-Flow Oxygen Therapy Reduces Discomfort During Hypoxemic Respiratory Failure

Abstract: Upper airway caliber was not significantly modified by HHFO₂, compared to standard oxygen therapy, but HHFO₂ significantly reduced discomfort in critically ill patients with respiratory failure. The system is usually preferred over standard oxygen therapy.

Cited by 152 publications

References 23 publications

Use of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department

Use of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department

Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects

High-flow nasal oxygen therapy and noninvasive ventilation in the management of acute hypoxemic respiratory failure

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