Heat transfer enhancement is a significant requirement in process industries. There are various passive and active methods available to reinforce the heat transfer. In the present study, tangential injection and its effect on the advancement in heat transfer rate are analysed. This is an active technique for enhancing heat transfer accompanied by negligible increment in pressure drop. Design and operating parameters like geometry, pipe material, working fluid, and flow rate play a vital role in heat transfer characteristics. Taking into account the design and operating parameters, the present study is aimed to optimize the orientation of the injecting nozzle. FLUENT software is employed to simulate the heat transfer and flow characteristics. A thorough grid independence study has been administered, and the present results are validated using the author’s previous experimental work. The tangential orientation considered is 30°, 45°, and 60°. The results show 60° inclination of the nozzle for parallel flow gives maximum overall heat transfer coefficient.