Heat-transfer based characterization of DNA on synthetic sapphire chips

Murib, Mohammed Sharif; Yeap, Weng Siang; Eurlings, Y.; Grinsven, Bart van; Boyen, Hans‐Gerd; Conings, Bert; Michiels, Luc; Ameloot, Marcel; Carleer, Robert; Warmer, Johannes; Kaul, Peter; Haenen, Ken; Schöning, Michael J.; Ceuninck, W. De; Wagner, Patrick

doi:10.1016/j.snb.2016.02.027

Cited by 11 publications

(13 citation statements)

References 58 publications

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“…The symmetrical and weak bands at 1660 cm À1 and 1706 cm À1 of the Si/WO 3 @solvent-APTES (curve 2) can be ascribed to the -NH2 groups of APTES and the -OH groups of water absorbed on the sample surface, respectively. 23,33,35 Those two peaks slightly shifted to 1646 and 1698 cm À1 in the Si/WO 3 @solvent-APTES-SA sample (curve 3). The shift indicates that SA was conjugated with APTES.…”

Section: Resultsmentioning

confidence: 98%

“…In the FTIR spectral of Si/WO 3 @O 2 plasma-APTES-SA samples, the band at 1703 cm À1 almost disappeared and the intensive peak at 1655 cm À1 was assigned to the C=O vibration of the succinic anhydride. 23,35,48,49 The new 1556 cm À1 peak (N-H) clearly indicates that SA has been bonded more efficiently to the APTES through the oxygen plasma treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the bands at 1646 cm À1 maybe assigned to the C=O bending vibration of SA. 23,35,48,49 For the Si/WO 3 @O 2 plasma-APTES sample (curve 4), the two bands at 1659 cm À1 (-NH2) and 1703 cm À1 (-OH) are asymmetrical, in which the 1659 cm À1 band is more dominant. In the FTIR spectral of Si/WO 3 @O 2 plasma-APTES-SA samples, the band at 1703 cm À1 almost disappeared and the intensive peak at 1655 cm À1 was assigned to the C=O vibration of the succinic anhydride.…”

Section: Resultsmentioning

confidence: 99%

“…), oxygen plasma treatment, etc., to create -OH groups on the sample surfaces, which improve subsequent silane growth. 23,25,32,35 In our experiments, the piranha treatment lifted the WO 3 thin films off the Si substrate. Therefore, we used the oxygen plasma treatment to activate the surface of the WO 3 thin films prior to surface functionalization with APTES and SA.…”

Section: Surface Functionalization Of Wo 3 Thin Films With Aptes and Samentioning

confidence: 99%

“…The thin films were surface-modified with 3-aminopropyltriethoxysilane (APTES) which acted as an amino-silane coupling agent for forming aminosilane monolayer. 23,[33][34][35] It was then followed by the further derivatization with succinic anhydride (SA). 23,35 The film of amino-silane coupled surface provided an active platform for subsequent biofunctionalization or linking biomolecules.…”

Section: Introductionmentioning

confidence: 99%

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Surface Functionalization of WO3 Thin Films with (3-Aminopropyl)triethoxysilane and Succinic Anhydride

Tran

et al. 2017

Journal of Elec Materi

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We report effects of oxygen plasma treatment on the surface functionalization of WO 3 thin films with (3-aminopropyl)triethoxysilane (APTES) and succinic anhydride (SA). X-ray diffraction and x-ray photoelectron spectroscopy results indicate the existence of the WO 3 phase. Fourier transform infrared spectroscopy measurement shows clear bands at 1040 cm À1 (Si-O-Si), 1556 cm À1 (N-H), 1655 cm À1 (C=O), 2937 cm À1 (C-H) and 3298 cm À1 (N-H), confirming the surface functionalization efficiency enhanced by prior treatment of oxygen plasma. It thus follows that the prior oxygen plasma treatment activates hydroxylation with more -OH groups on the WO 3 surface, which can pave a highly efficient way to the surface functionalization by APTES and SA.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Surface Functionalization Of Wo 3 Thin Films With Aptes and Samentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Surface Functionalization of WO3 Thin Films with (3-Aminopropyl)triethoxysilane and Succinic Anhydride

Tran

et al. 2017

Journal of Elec Materi

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High‐Throughput Dielectrophoretic Trapping and Detection of DNA Origami

Ghomian

Jeong

Pan

et al. 2021

Adv Materials Inter

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Accurate control over the location of nanostructured materials for studying their electronic properties is important for the development of useful electronic devices. Dielectrophoresis is a unique method for trapping non‐symmetric nanostructured materials between two electrodes in a specific direction. However, this method has traditionally suffered from a costly and slow fabrication process as well as low efficiency when trapping high‐impedance nanomaterials. In this work, a dielectrophoretic device addressing the mentioned problems, is reported. First, a photolithography‐based fabrication process achieves high throughput and low‐cost devices with nanostructured contacts for attaching nanomaterials. Second, trapping of high‐impedance nanomaterials is controlled using a scalable‐electronic circuit that measures the capacitance variation at the trap location to identify when the nanomaterials of interest are attached to the electrode. As a primary target of interest, the trapping of 1D deoxyribonucleic acid (DNA) origamis is demonstrated. It is shown that a capacitance change in the range of 18% to 60% guarantees the presence of a single or a few DNA origamis in the trap location well‐aligned with nanoelectrodes. Fluorescent, scanning electron microscopy, and atomic force microscopy images demonstrate the presence of DNA origamis in the trap location with the correct orientation.

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Nanomagnet Bioconjugates with anti‐CRP Polyclonal Antibodies as Nanobioprobes for Enhanced Impedimetric Detection of CRP

2022

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Selective purification of biological materials for their detection in complex sample matrix is a general challenge for many researchers working in the field of diagnostics. Magnetic nanoparticles functionalized with biological molecules that impart biomolecular selectivity are therefore of major interest as capture probes thus allowing for magnetic separations. Nanoparticles can also be used for the enhanced detection of biomarkers. In this work, an ultrasensitive sandwich-based impedimetric immunosensor was fabricated for the detection of Creactive protein antigen (CRPAg). Stable and oriented immobilization of anti-CRP monoclonal antibody was achieved onto electrografted phenylethylamine derivat-ized with succinic anhydride and phenylboronic acid via carbodiimide chemistry. The detection of CRPAg was achieved using Electrochemical Impedance Spectroscopy (EIS). The enhancement of the impedance charge-transfer resistance (R CT ) signal was achieved using the sandwich approach. The anti-CRP polyclonal antibody was immobilized in an oriented manner onto magnetic nanoparticles functionalized with phenylboronic acid. The increase in the change in charge-transfer resistance (ΔR CT ) values was linearly proportional to the concentration of CRPAg in the range 10 to 200 ng mL À 1 covering the clinical range for CRPAg detection and with a detection limit of 0.34 ng mL À 1 .

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Heat-transfer based characterization of DNA on synthetic sapphire chips

Cited by 11 publications

References 58 publications

Surface Functionalization of WO3 Thin Films with (3-Aminopropyl)triethoxysilane and Succinic Anhydride

Surface Functionalization of WO3 Thin Films with (3-Aminopropyl)triethoxysilane and Succinic Anhydride

High‐Throughput Dielectrophoretic Trapping and Detection of DNA Origami

Nanomagnet Bioconjugates with anti‐CRP Polyclonal Antibodies as Nanobioprobes for Enhanced Impedimetric Detection of CRP

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