Heat therapy improves soleus muscle force in a model of ischemia-induced muscle damage

Kim, Kyoungrae; Reid, Blake A.; Ro, Bohyun; Casey, Caitlin A.; Song, Qifan; Kuang, Shihuan; Roseguini, Bruno T.

doi:10.1152/japplphysiol.00115.2019

Cited by 18 publications

(17 citation statements)

References 65 publications

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“…This seems unlikely given the accumulating evidence derived from animal studies that repeated heat stress enhances muscle strength and prevents disuse-induced muscle weakness. For instance, we recently reported that repeated immersion in a water bath at 37°C and 39°C for 3 weeks enhanced maximal absolute force of the soleus muscle in a model of ischemia-induced muscle damage (23). Similarly, Yoshihara and colleagues reported that 3 days of whole-body HT using a heat chamber (40-41°C for min) abrogated ventilator-induced diaphragm contractile dysfunction in rats (40).…”

Section: Limitationsmentioning

confidence: 92%

Effects of repeated local heat therapy on skeletal muscle structure and function in humans

Kim

Reid

Casey

et al. 2020

Journal of Applied Physiology

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Introduction Short‐term exposure to heat stress has been shown to enhance muscle strength and elicit mitochondrial adaptations in human skeletal muscle. We recently documented that exposure to five sessions of heat therapy (HT) accelerates the recovery of fatigue resistance following exercise‐induced muscle damage in humans. However, the long‐term impact of repeated exposure to local heat stress on contractile function and skeletal muscle structure remains unknown. The purpose of the present study was to examine the effects of 8 weeks of daily treatment with local HT on muscle strength, fatigability, fiber size and mitochondrial content in humans. Methods Twelve healthy young adults (23.6±1.4 years, BMI 24.9±0.9 kg/m2) had one randomly selected thigh treated with daily HT for 8 consecutive weeks while the opposite thigh served as a control. A water‐circulating garment perfused with water at ~52ºC was used to apply HT for 90 min daily. Knee extensor strength (single peak torque during 3 repetition maximums at 180°/s and 60°/s) and fatigue resistance (total work during 40 repetition maximums at 180°/s) were assessed using isokinetic dynamometry before and after 4 and 8 weeks of treatment. Biopsies were obtained from the vastus lateralis muscle for the determination of myofiber cross‐sectional area and maximal citrate synthase activity. Results Treatment with HT elicited an increase in thigh skin temperature (39.8±0.1ºC), while skin temperature remained at baseline levels in the control thigh (32.4± 0.1ºC). A significant treatment effect was observed for the changes from baseline in peak isokinetic torque at 180º/s (p=0.04). On average, the changes in peak isokinetic torque from baseline for HT were ~2 fold higher than control at week 4 (Control: 4.1±3.7 Nm vs. HT: 9±4.6 Nm) and ~4 fold higher at week 8 (Control: 1.7±2.7 Nm vs. HT: 7.7±2.9 Nm). There were no differences between treatments for peak isokinetic torque at 60º/s, myofiber cross‐sectional area and citrate synthase activity. Conclusion These results indicate that daily exposure to HT for 8 weeks enhances muscle strength in humans. Local HT may be a practical therapeutic approach to improve muscle function in individuals with limited mobility and skeletal muscle weakness. Support or Funding Information Support: American College of Sports Medicine Research Endowment This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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Section: Limitationsmentioning

confidence: 92%

Effects of repeated local heat therapy on skeletal muscle structure and function in humans

Kim

Reid

Casey

et al. 2020

Journal of Applied Physiology

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“…Chronic heat therapies have been used in both animal models of PAD and patients with PAD. Roseguini's group has explored the impacts of chronic heat therapy in murine models of chronic hindlimb ischemia [47,48]. Kim et al (2019) found that muscular mass (+7%) in the ischemic limb was greater following heat therapy compared to control [47].…”

Section: Clinical Applications Of Heat Therapymentioning

confidence: 99%

“…Roseguini's group has explored the impacts of chronic heat therapy in murine models of chronic hindlimb ischemia [47,48]. Kim et al (2019) found that muscular mass (+7%) in the ischemic limb was greater following heat therapy compared to control [47]. In a similar investigation, Kim et al (2020) found that in addition to preserving muscle mass, heat therapy treatment may also be beneficial for improving body composition in an obese murine model of hindlimb ischemia.…”

Section: Clinical Applications Of Heat Therapymentioning

confidence: 99%

Microvascular Dysfunction in Peripheral Artery Disease: Is Heat Therapy a Viable Treatment?

Anderson

Pekas

Park

2021

IJERPH

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Peripheral artery disease (PAD) is characterized by the development of atherosclerotic plaques in the lower-body conduit arteries. PAD is commonly accompanied by microvascular disease, which may result in poor wound healing, plantar ulcer development, and subsequent limb amputation. Understanding the mechanisms underlying the development of plantar ulcers is a critical step in the development of adequate treatment options for patients with PAD. Skin is classified into two major components: glabrous and non-glabrous. These skin types have unique microcirculation characteristics, making it important to differentiate between the two when investigating mechanisms for plantar ulcer development in PAD. There is evidence for a microcirculation compensatory mechanism in PAD. This is evident by the maintenance of basal microcirculation perfusion and capillary filling pressure despite a reduced pressure differential beyond an occlusion in non-critical limb ischemia PAD. The major mechanism for this compensatory system seems to be progressive vasodilation of the arterial network below an occlusion. Recently, heat therapies have emerged as novel treatment options for attenuating the progression of PAD. Heat therapies are capable of stimulating the cardiovascular system, which may lead to beneficial adaptations that may ultimately reduce fatigue during walking in PAD. Early work in this area has shown that full-body heating is capable of generating an acute cardiovascular response, similar to exercise, which has been suggested as the most efficient treatment modality and may generate adaptations with chronic exposure. Heat therapies may emerge as a conservative treatment option capable of attenuating the progression of PAD and ultimately impeding the development of plantar ulcers.

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“…Considering the aspects of limited conduit artery blood flow and impaired endothelium-dependent vasodilation during physical activity in this population, there will probably be an increased reliance on the microcirculation to meet the metabolic demands of the contracting muscle. Therefore, novel strategies targeting skeletal muscle myopathy to reverse muscle atrophy [66,67] that can be used in addition to those targeting capillary rarefaction [68,69] hold great potential to produce greater and more sustainable clinical impact.…”

Section: Skeletal Muscle Pathology In Padmentioning

confidence: 99%

Skeletal Muscle Mitochondrial Dysfunction and Oxidative Stress in Peripheral Arterial Disease: A Unifying Mechanism and Therapeutic Target

et al. 2020

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Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities, which leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest pain, and gangrene requiring limb amputation. Current treatments for PAD are focused primarily on re-establishing blood flow to the ischemic tissue, implying that blood flow is the decisive factor that determines whether or not the tissue survives. Unfortunately, failure rates of endovascular and revascularization procedures remain unacceptably high and numerous cell- and gene-based vascular therapies have failed to demonstrate efficacy in clinical trials. The low success of vascular-focused therapies implies that non-vascular tissues, such as skeletal muscle and oxidative stress, may substantially contribute to PAD pathobiology. Clues toward the importance of skeletal muscle in PAD pathobiology stem from clinical observations that muscle function is a strong predictor of mortality. Mitochondrial impairments in muscle have been documented in PAD patients, although its potential role in clinical pathology is incompletely understood. In this review, we discuss the underlying mechanisms causing mitochondrial dysfunction in ischemic skeletal muscle, including causal evidence in rodent studies, and highlight emerging mitochondrial-targeted therapies that have potential to improve PAD outcomes. Particularly, we will analyze literature data on reactive oxygen species production and potential counteracting endogenous and exogenous antioxidants.

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Heat therapy improves soleus muscle force in a model of ischemia-induced muscle damage

Cited by 18 publications

References 65 publications

Effects of repeated local heat therapy on skeletal muscle structure and function in humans

Effects of repeated local heat therapy on skeletal muscle structure and function in humans

Microvascular Dysfunction in Peripheral Artery Disease: Is Heat Therapy a Viable Treatment?

Skeletal Muscle Mitochondrial Dysfunction and Oxidative Stress in Peripheral Arterial Disease: A Unifying Mechanism and Therapeutic Target

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