Heat stress upregulates G-T mismatch binding activities in zebrafish (Danio rerio) embryos preexposed and nonexposed to a sublethal level of cadmium (Cd)

Ho, Tung‐Yuan; Paul, Ganjai Vikram; Chen, Yen-Hung; Hsu, Todd

doi:10.1016/j.chemosphere.2018.11.038

Cited by 8 publications

(1 citation statement)

References 45 publications

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“…This response was also observed at the transcriptional level, with the up-regulation of GPx genes in several tissues of teleost fish under thermal stress, including black porgy (Acanthopagrus schlegeli) [57] and pufferfish [58], as well as in red cusk-eel eggs under thermal stress [23], where gpx1 was increased, an effect not observed for this species in skeletal muscle [24]. Additionally, the effect of high-temperature stress on the liver related to DNA damage was also observed at the transcriptional level, with the up-regulation of genes involved in DNA mismatch repair (msh2 and msh3), concordant with the previously reported effect of thermal stress on zebrafish (Danio rerio) [59] and American lobster [60]. However, the thermal stress response associated with oxidative stress in teleost fish could vary according to species and tissues, as observed in sheepshead minnow (Cyprinodon variegatus), where a limited effect on antioxidant enzymes and no lipid peroxidation were present [61], in contrast to the variable lipid peroxidation observed in Senegalese sole [55].…”

Section: Oxidative Stress Under High-temperature Stresssupporting

confidence: 87%

High-Temperature Stress Effect on the Red Cusk-Eel (Geypterus chilensis) Liver: Transcriptional Modulation and Oxidative Stress Damage

Dettleff

Zuloaga

Fuentes

et al. 2022

Biology

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Environmental stressors, such as temperature, are relevant factors that could generate a negative effect on several tissues in fish. A key fish species for Chilean aquaculture diversification is the red cusk-eel (Genypterus chilensis), a native fish for which knowledge on environmental stressors effects is limited. This study evaluated the effects of high-temperature stress on the liver of red cusk-eel in control (14 °C) and high-temperature (19 °C) groups using multiple approaches: determination of plasmatic hepatic enzymes (ALT, AST, and AP), oxidative damage evaluation (AP sites, lipid peroxidation, and carbonylated proteins), and RNA-seq analysis. High-temperature stress generated a significant increase in hepatic enzyme activity in plasma. In the liver, a transcriptional regulation was observed, with 1239 down-regulated and 1339 up-regulated transcripts. Additionally, high-temperature stress generated oxidative stress in the liver, with oxidative damage and transcriptional modulation of the antioxidant response. Furthermore, an unfolded protein response was observed, with several pathways enriched, as well as a heat shock response, with several heat shock proteins up regulated, suggesting candidate biomarkers (i.e., serpinh1) for thermal stress evaluation in this species. The present study shows that high-temperature stress generated a major effect on the liver of red cusk-eel, knowledge to consider for the aquaculture and fisheries of this species.

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