Heat Stress Modulates Brain Monoamines and Their Metabolites Production in Broiler Chickens Co-Infected with Clostridium perfringens Type A and Eimeria spp.

Calefi, Atílio Sersun; Fonseca, Juliana Garcia da Silva; Nunes, Catarina Augusta de Queiroz; Lima, Ana Paula Nascimento de; Quinteiro-Filho, W.M.; Flório, Jorge Camilo; Zager, Adriano; Ferreira, Antônio José Piantino; Palermo-Neto, João

doi:10.3390/vetsci6010004

Cited by 14 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study with broiler chickens, heat stress and/or intestinal infection with Clostridium and Eimeria spp. (bacteria and protozoal species, respectively) led to changes in concentrations of monoamines in key brain regions, including a decrease in 5-HT, NE, and E in the hypothalamus, and dopamine in the mid-brain ( Calefi et al, 2019 ). Authors speculated that these data demonstrated activation of the HPA axis via increased release of cytokines from intestinal immune cells, in response to the pathogen challenge.…”

Section: Heat Stress Activates the Hpa Axismentioning

confidence: 99%

The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

et al. 2021

View full text Add to dashboard Cite

Heat stress is a global issue for the poultry industries with substantial annual economic losses and threats to bird health and welfare. When chickens are exposed to high ambient temperatures, like other species they undergo multiple physiological alterations, including behavioral changes, such as cessation of feeding, initiation of a stress signaling cascade, and intestinal immune, and inflammatory responses. The brain and gut are connected and participate in bidirectional communication via the nervous and humoral systems, this network collectively known as the gut-brain axis. Moreover, heat stress not only induces hyperthermia and oxidative stress at the gut epithelium, leading to impaired permeability and then susceptibility to infection and inflammation, but also alters the composition and abundance of the microbiome. The gut microflora, primarily via bacterially derived metabolites and hormones and neurotransmitters, also communicate via similar pathways to regulate host metabolic homeostasis, health, and behavior. Thus, it stands to reason that reshaping the composition of the gut microbiota will impact intestinal health and modulate host brain circuits via multiple reinforcing and complementary mechanisms. In this review, we describe the structure and function of the microbiota-gut-brain axis, with an emphasis on physiological changes that occur in heat-stressed poultry.

show abstract

Section: Heat Stress Activates the Hpa Axismentioning

confidence: 99%

The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, it is believed that serotonin regulates the process of bone formation, as well as the mechanism of bone resorption [ 15 ]. In this context, Calefi et al [ 16 ] reported that acute stress conditions such as environmental temperature increases the concentration of serotonin in brain tissues; however, chronic stress conditions decrease the level of brain serotonin. Therefore, the aim of the current work is to analyze changes in the brain serotonin, liver CoQ10, energy metabolism, antioxidant biomarkers, and blood chemistry of broiler chickens subjected to chronic thermal stress.…”

Section: Introductionmentioning

confidence: 99%

Effects of Chronic Thermal Stress on Performance, Energy Metabolism, Antioxidant Activity, Brain Serotonin, and Blood Biochemical Indices of Broiler Chickens

Ahmed-Farid

Salah

Nassan

2021

Animals

View full text Add to dashboard Cite

The aim of this paper was to investigate the effects of chronic thermal stress on the performance, energy metabolism, liver CoQ10, brain serotonin, and blood parameters of broiler chickens. In total, 100 one-day-old chicks were divided into two equal groups of five replicates. At 22 days of age and thereafter, the first group (TN) was maintained at a thermoneutral condition (23 ± 1 °C), while the second group (TS) was subjected to 8 h of thermal stress (34 °C). The heat-stressed group showed significantly lower ADFI but higher FCR than the thermoneutral group (p = 0.030 and 0.041, respectively). The TS group showed significantly higher serum cholesterol, ALT, and AST (p = 0.033, 0.024, and 0.010, respectively). Meanwhile, the TS group showed lower serum total proteins, albumin, globulin, and Na+ than the TN group (p = 0.001, 0.025, 0.032, and 0.002, respectively). Furthermore, the TS group showed significantly lower SOD and catalase in heart tissues (p = 0.005 and 0.001, respectively). The TS group showed significantly lower liver ATP than the TN group (p = 0.005). Meanwhile, chronic thermal stress significantly increased the levels of ADP and AMP in the liver tissues of broiler chickens (p = 0.004 and 0.029, respectively). The TS group showed significantly lower brain serotonin (p = 0.004) and liver CoQ10 (p = 0.001) than the TN group. It could be concluded that thermal stress disturbed the antioxidant defense system and energy metabolism and exhausted ATP levels in the liver tissues of broiler chickens. Interestingly, chronic thermal stress reduced the level of brain serotonin and the activity of CoQ10 in liver tissues.

show abstract

“…Moreover, activation of the HPA axis leads to sickness behavior in chickens, owing to elevated cortisol secretion. A combination of decreased feed intake, weight loss, decreased movement, and increased sleepiness is considered as sickness behavior in chickens [36]. Proposed gut-brain axis model for chickens.…”

Section: Gut-brain Axis and Gut Healthmentioning

confidence: 99%

“…Thus, signals may transduce to the brain and influence cognition and behavior or cause changes in the enteric system and provide feedback on the microbiota. Calefi et al [36] analyzed the neurochemical profile in the hypothalamus, midbrain, and brainstem of broiler chickens exposed to Eimeria spp., Clostridium perfringens (C. perfringens), and heat stress. The findings of this study showed that exposure to C. perfringens elevates the dopamine levels in the hypothalamus, rostral pallium, and midbrain.…”

Section: Gut-brain Axis and Gut Healthmentioning

confidence: 99%

Role of Physiology, Immunity, Microbiota, and Infectious Diseases in the Gut Health of Poultry

et al. 2022

View full text Add to dashboard Cite

“Gut health” refers to the physical state and physiological function of the gastrointestinal tract and in the livestock system; this topic is often focused on the complex interacting components of the intestinal system that influence animal growth performance and host-microbial homeostasis. Regardless, there is an increasing need to better understand the complexity of the intestinal system and the various factors that influence gut health, since the intestine is the largest immune and neuroendocrine organ that interacts with the most complex microbiome population. As we face the post-antibiotic growth promoters (AGP) era in many countries of the world, livestock need more options to deal with food security, food safety, and antibiotic resilience to maintain agricultural sustainability to feed the increasing human population. Furthermore, developing novel antibiotic alternative strategies needs a comprehensive understanding of how this complex system maintains homeostasis as we face unpredictable changes in external factors like antibiotic-resistant microbes, farming practices, climate changes, and consumers’ preferences for food. In this review, we attempt to assemble and summarize all the relevant information on chicken gut health to provide deeper insights into various aspects of gut health. Due to the broad and complex nature of the concept of “gut health”, we have highlighted the most pertinent factors related to the field performance of broiler chickens.

show abstract

Heat Stress Modulates Brain Monoamines and Their Metabolites Production in Broiler Chickens Co-Infected with Clostridium perfringens Type A and Eimeria spp.

Cited by 14 publications

References 42 publications

The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

Effects of Chronic Thermal Stress on Performance, Energy Metabolism, Antioxidant Activity, Brain Serotonin, and Blood Biochemical Indices of Broiler Chickens

Role of Physiology, Immunity, Microbiota, and Infectious Diseases in the Gut Health of Poultry

Contact Info

Product

Resources

About