Heat stress effects on bovine sperm cells: a chronological approach to early findings

Garcia‐Oliveros, Laura Nataly; Arruda, Rubens Paes de; Batissaco, Leonardo; Gonzaga, Vitor Hugo Guilger; Nogueira, Vinícius José Moreira; Florez-Rodriguez, S. A.; Almeida, Felipe P.; Alves, Maíra Bianchi Rodrigues; Pinto, Sâmara Cristine Costa; Nichi, Marcílio; Losano, João Diego de Agostini; Kawai, Giulia Kiyomi Vechiato; Celeghini, Eneiva Carla Carvalho

doi:10.1007/s00484-020-01917-w

Cited by 35 publications

(26 citation statements)

References 49 publications

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“…EHS effects were stilled observed after 3 days following EHS onset at least. Based on a recent report of Garcia-Oliveros et al 33 , EHS might first cause an increase in testes morphological defects, followed by increased sperm lipid peroxidation, thereby inducing mitochondrial distress, reduced sperm motility, and sperm DNA fragmentation.…”

Section: Discussionmentioning

confidence: 99%

Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

Lin

Huang

Tian

et al. 2021

Sci Rep

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The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erectile function, and testicular morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) to induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, hypothalamic cell damage, systemic inflammation, coagulopathy, and multiple organ injury. In particular, EHS animals had erectile dysfunction (as determined by measuring the changes of intracavernosal pressure and mean arterial pressure in response to electrical stimulation of cavernous nerves). Rats also displayed testicular temperature disruption, poorly differentiated seminiferous tubules, impaired sperm quality, and atrophy of interstitial Leydig cells, Sertoli cells, and peri-tubular cells in the testicular tissues accompanied by no spermatozoa and broken cells with pyknosis in their seminal vesicle and prostatitis. These EHS effects were still observed after 3 days following EHS onset, at least. Our findings provide a greater understanding of the effect of experimentally induced EHS on masculine sexual behavior, fertility, stress hormones, and morphology of both testis and prostate.

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Section: Discussionmentioning

confidence: 99%

Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

Lin

Huang

Tian

et al. 2021

Sci Rep

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“…It is reported that long-term scrotal insulation could affect sperm quality due to disruption in spermatogenesis [ 44 ]. The common findings in ejaculates related to the increase at scrotal surface temperature are a reduced sperm output (ram: [ 48 , 49 ]; lama: [ 50 ]), a lower proportion of motile sperm (bull: [ 45 , 51 ]; dog: [ 47 ] ram: [ 48 , 49 ]; lama: [ 50 ]), and a more frequent occurrence of spermatozoa with altered morphology (bull: [ 16 , 18 , 51 , 52 ], ram: [ 48 ]; lama: [ 50 ]). Contrary to what was expected, the results of the current study demonstrated that there was a moderate negative correlation between the increase in the scrotal temperature and the sperm abnormalities in the concurrent ejaculate.…”

Section: Discussionmentioning

confidence: 99%

Use of Infrared Thermography during Ejaculation Process and Its Link with Semen Quality and Freezability in Dogs

Tekin

̇İnanç

Özen

et al. 2021

Animals

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This study aimed to describe the thermal variation of external reproductive tracts during ejaculation in relation to sperm quality in dogs. Forty-six adult fertile dogs were monitored using a thermal camera before, during and after the semen collection, taking into account penile and scrotal temperatures as reproductive thermal patterns while eye and perianal temperatures were recorded as complementary thermal patterns of behavioral response. The parameters were classified depending on age (≤4 years and >4 years), body weight (BW) (≤75 kg and >75 kg), sperm concentration (CON) (≤300 million and >300 million), total testicular volume (TTV) (≤600 cm3 and >600 cm3) and total ejaculation time (TET) (≤800 s and >800 s) of the animals from which semen was collected successfully. Heavier males (p < 0.05) that have more consistent testicles (p < 0.01) as well as quicker ejaculate responders (p < 0.001) and lower scrotal temperature had better semen (Δ motility) freezability. The lower eye temperature prior to the ejaculation (p < 0.01), lower scrotal temperature following ejaculation (p < 0.01), and conversely, higher penile temperature during the ejaculation (p < 0.001) had a higher sperm concentration. Furthermore, the sperm freezability was negatively correlated with total ejaculation time (r = −0.39, p < 0.05) and sperm abnormalities were lower in the ejaculate of dogs having a higher temperature of the scrotum, bulbus and penis. In conclusion, infrared monitoring throughout semen collection in dogs can provide information on behavioral reactions during human manipulation, as well as semen quality and testicular functionality.

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“…A recent study on male rats reported that exertional heatstroke can cause erectile dysfunctions, disruption of testicular temperature, poorly differentiated seminiferous tubules, diminished sperm quality, loss of interstitial Leydig cells, Sertoli cells, leading to azoospermia and infertility [117]. Another similar study conducted on bovine sperm also reported that heat stress in bulls induces seminal plasma oxidative stress thereby affecting the sperm mitochondrial function, motility, plasma membrane integrity, and DNA fragmentation, ultimately leading to infertility [118]. Another study observed the impact of wet heat exposure in the forms of hot tubs, Jacuzzi or hot baths in infertile male partners and concluded that the toxic effects of wet heat exposure are reversible, and withdrawal of hyperthermia resulted in increased sperm motility and quality in these patients, further supporting the fact that excessive heat exposure affects sperm parameters and can cause infertility in males [119].…”

Section: Heat Exposurementioning

confidence: 99%

Impact of environmental factors on human semen quality and male fertility: a narrative review

Kumar

Singh

2022

Environ Sci Eur

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Background Worldwide rising trend in infertility has been observed in the past few years with male infertility arising as a major problem. One main reason for the rise in male infertility cases is declining semen quality. It was found that any factor that affects semen quality can affect male fertility. There are several modifiable factors affecting semen quality including air pollution, use of pesticides and harmful chemicals, exposure to excessive heat, and can lead to decreased male fertility. Main body The present review focuses on some of these environmental factors that affect semen quality and hence, can cause male infertility. The literature from 2000 till June 2021 was searched from various English peer-reviewed journals and WHO fact sheets using the USA National Library of Medicine (PubMed) database, the regional portal of Virtual Health Library, and Scientific Electronic Library Online. The search terms used were: “Air pollution and male fertility”, “Chemicals and male infertility”, “Heat exposure and infertility”, “heavy metals and male fertility”. Conclusion Adverse environmental factors have a significant impact on semen quality, leading to decreased sperm concentration, total sperm count, motility, viability, and increased abnormal sperm morphology, sperm DNA fragmentation, ultimately causing male infertility. However, all these factors are modifiable and reversible, and hence, by mere changing of lifestyle, many of these risk factors can be avoided.

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Heat stress effects on bovine sperm cells: a chronological approach to early findings

Cited by 35 publications

References 49 publications

Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

Use of Infrared Thermography during Ejaculation Process and Its Link with Semen Quality and Freezability in Dogs

Impact of environmental factors on human semen quality and male fertility: a narrative review

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