Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis

Vijayavittal, Abhijnya Kanugovi; Kumar, Pankaj; Sugunan, Sreedevi; Joseph, Chitra; Devaki, Bharath; Paithankar, Khanderao; Subbarao, Sreedhar Amere

doi:10.1016/j.bbrc.2022.02.018

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…The oxidation by reactive oxygen species improves C. neoformans Hsf3’s mitochondrial DNA binding affinity. In a separate study, mammalian Hsf2 was suggested to be the redox sensor that determines cell fate via its regulation axis of HSF2-BTG2-SOD2, in which ROS activation of mammalian Hsf2 triggers the gene expression of BTG2 and SOD2 ( Kanugovi Vijayavittal et al., 2022 ). The major disparity between two sensing mechanisms is that C. neoformans Hsf3 does not control gene expression of SOD2 ( Gao et al., 2022 ).…”

Section: Noncanonical Function Of Heat Shock Transcription Factor In ...mentioning

confidence: 99%

The function and regulation of heat shock transcription factor in Cryptococcus

Suo

Gao

Ding

et al. 2023

Front. Cell. Infect. Microbiol.

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Cryptococcus species are opportunistic human fungal pathogens. Survival in a hostile environment, such as the elevated body temperatures of transmitting animals and humans, is crucial for Cryptococcus infection. Numerous intriguing investigations have shown that the Hsf family of thermotolerance transcription regulators plays a crucial role in the pathogen-host axis of Cryptococcus. Although Hsf1 is known to be a master regulator of the heat shock response through the activation of gene expression of heat shock proteins (Hsps). Hsf1 and other Hsfs are multifaceted transcription regulators that regulate the expression of genes involved in protein chaperones, metabolism, cell signal transduction, and the electron transfer chain. In Saccharomyces cerevisiae, a model organism, Hsf1’s working mechanism has been intensively examined. Nonetheless, the link between Hsfs and Cryptococcus pathogenicity remains poorly understood. This review will focus on the transcriptional regulation of Hsf function in Cryptococcus, as well as potential antifungal treatments targeting Hsf proteins.

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Section: Noncanonical Function Of Heat Shock Transcription Factor In ...mentioning

confidence: 99%

The function and regulation of heat shock transcription factor in Cryptococcus

Suo

Gao

Ding

et al. 2023

Front. Cell. Infect. Microbiol.

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“…The role of HSPs in autophagy. An important role in the process of autophagy is its regulation by HSPs (104)(105)(106). During heat shock, HSP production and autophagy activation are reactions aimed at maintaining the quality of cellular proteins and they complement each other under cellular stress (107,108).…”

Section: The Role Of Hsps In Regulated Cell Deathmentioning

confidence: 99%

The role of heat shock proteins in the pathogenesis of heart failure (Review)

Sklifasovskaya,

Blagonravov,

Ryabinina

et al. 2023

Int J Mol Med

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The influence of heat shock proteins (HSPs) on protein quality control systems in cardiomyocytes is currently under investigation. The effect of HSPs on the regulated cell death of cardiomyocytes (CMCs) is of great importance, since they play a major role in the implementation of compensatory and adaptive mechanisms in the event of cardiac damage. HSPs mediate a number of mechanisms that activate the apoptotic cascade, playing both pro- and anti-apoptotic roles depending on their location in the cell. Another type of cell death, autophagy, can in some cases lead to cell death, while in other situations it acts as a cell survival mechanism. The present review considered the characteristics of the expression of HSPs of different molecular weights in CMCs in myocardial damage caused by heart failure, as well as their role in the realization of certain types of regulated cell death.

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“…Sistonen and her colleagues discovered that HSF2 regulates cadherin superfamily genes and maintains protein homeostasis (proteostasis [ 65 ]) for cell survival against proteotoxicity including protein aggregation [ 66 ]. Subbarao and his colleagues suggested that HSF2 controls non-selective (micro/macro) and selective (chaperone-mediated) autophagy [ 67 ].…”

Section: Hsf2 Is Required For the Suppression Of Polyglutamine Diseas...mentioning

confidence: 99%

Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases

Tokunaga

Otsuyama

Kakuta

et al. 2022

IJMS

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HSF (heat shock transcription factor or heat shock factor) was discovered as a transcription factor indispensable for heat shock response. Although four classical HSFs were discovered in mammals and two major HSFs, HSF1 and HSF2, were cloned in the same year of 1991, only HSF1 was intensively studied because HSF1 can give rise to heat shock response through the induction of various HSPs’ expression. On the other hand, HSF2 was not well studied for some time, which was probably due to an underestimate of HSF2 itself. Since the beginning of the 21st century, HSF2 research has progressed and many biologically significant functions of HSF2 have been revealed. For example, the roles of HSF2 in nervous system protection, inflammation, maintenance of mitosis and meiosis, and cancer cell survival and death have been gradually unveiled. However, we feel that the fact HSF2 has a relationship with various factors is not yet widely recognized; therefore, the biological significance of HSF2 has been underestimated. We strongly hope to widely communicate the significance of HSF2 to researchers and readers in broad research fields through this review. In addition, we also hope that many readers will have great interest in the molecular mechanism in which HSF2 acts as an active transcription factor and gene bookmarking mechanism of HSF2 during cell cycle progression, as is summarized in this review.

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Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis

Cited by 4 publications

References 37 publications

The function and regulation of heat shock transcription factor in Cryptococcus

The function and regulation of heat shock transcription factor in Cryptococcus

The role of heat shock proteins in the pathogenesis of heart failure (Review)

Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases

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