Heat shock proteins and heat therapy for type 2 diabetes

Krause, Maurício; Ludwig, Mirna Stela; Heck, Thiago Gomes; Takahashi, Hilton Kenji

doi:10.1097/mco.0000000000000183

Cited by 60 publications

(54 citation statements)

References 22 publications

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“…2,3 There are many factors involved in the development and treatment of insulin resistance, with the roles played by both thermal therapy and heat shock proteins (HSPs) receiving increased attention. [4][5][6][7] Furthermore, it has been suggested that HSPs may provide an early indicator of the onset of metabolic diseases, such as type 2 diabetes (T2DM), 8,9 while also acting as a possible biomarker for the chronicity of diabetes. 10 HSPs are synthesized in response to a number of physiological stressors, [11][12][13] and are individually characterized by their molecular weight.…”

Section: Introductionmentioning

confidence: 99%

The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

et al. 2017

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Increasing physical activity remains the most widely publicized way of improving health and wellbeing. However, in populations that benefit most from exercise (EX), adherence is often poor and alternatives to EX are important to bring about health improvements. Recent work suggests a role for passive heating (PH) and heat shock proteins (HSP) in improving cardio-metabolic health. The aim of this study was to investigate the expression of HSP70 and interleukin-6 in response to either EX or PH and the subsequent effect on glucose control. Fourteen males volunteered and were categorized lean (BMI 23.5 § 2.2 kg¢m ¡2 ) or overweight (29.2 § 2.7 kg¢m ¡2 ) and completed 60 minutes of either moderate cycling at a fixed rate of metabolic heat production (EX) or warm water immersion in 40 C water (PH). Extracellular HSP70 increased from baseline in both conditions with no differences between PH (0.98 § 1.1 ng¢mL ¡1 ) or EX (0.84 § 1.0 ng¢mL ¡1 , p D 0.814). IL-6 increased following both conditions with a two-fold increase after PH and four-fold after EX. Energy expenditure increased by 61.0 § 14.4 kcal¢h ¡1 (79%) after PH. Peak glucose concentration after a meal immediately following PH was reduced when compared with EX (6.3 § 1.4 mmol¢L ¡1 versus 6.8 § 1.2 mmol¢L ¡1 ; p < 0.05). There was no difference in 24-hour glucose area under the curve (AUC) between conditions. These data indicate the potential for thermal therapy as an alternative treatment and management strategy for those at risk of developing metabolic disease where adherence, or ability to EX, may be compromised.

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Section: Introductionmentioning

confidence: 99%

The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

et al. 2017

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“…The activation of iHSP70 is critical for the promotion of tissue repair, since the expression of this chaperone, by virtue of avoiding misfolded protein aggregates, confers cytoprotection and also exerts anti-inflammatory effects [39]. Hence, since aging is associated with chronic low-grade inflammation and impaired skeletal muscle repair, the activation of HSP70 expression and its effective response against cellular stress play a key role against cell dysfunction observed in aging.…”

Section: Anti-misfolding Protein Quality Control Systemsmentioning

confidence: 99%

“…In a recent study, our group observed that the ratio between plasma eHSP70 and cellular iHSP70 in lymphocytes from rats submitted to different loads of acute exercise (an acute stressful situation) can indicate the inflammatory status [34]. Indeed, extracellular to intracellular HSP70 ratio index (H-index) measured in peripheral blood mononuclear cells (PBMC) in relation to serum values has been recently assumed as novel and overall index of immunoinflammatory status of an individual [34,39,105,112]. The rationale for this is that the higher eHSP70 amounts, the more inflammatory signals are coming into play because eHSP70 is proinflammatory in nature.…”

Section: Anti-inflammatory Role Of Intracellular Hsp70mentioning

confidence: 99%

“…Inducers of the HS response, such as physical exercise, heat treatment itself (e.g., hot tub, sauna), and calorie restriction may efficiently interrupt the vicious cycle of age-related chronic degenerative diseases of inflammatory nature in elderly, being envisaged as the best and most economical treatments for such chronic diseases [7,39]. Extracellular to intracellular HSP70 ratio index (H-index), measured in PCMC in relation to serum values, has also been recently described as novel and overall index of immunoinflammatory status of an individual and could be invaluable in estimating immunoinflammatory status in as many different situations as immune responses, obesities, T2DM, CVD, and immunological impacts of exercise in aging [34].…”

Section: Physical Exercise Glutamine and Hs Response In Agingmentioning

confidence: 99%

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Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions

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Krause

et al. 2016

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Aging is an intricate process modulated by different molecular and cellular events, such as genome instability, epigenetic and transcriptional changes, molecular damage, cell death and senescence, inflammation, and metabolic dysfunction. Particularly, protein quality control (chaperone systems) tends to be negatively affected by aging, thus leading to cellular senescence in metabolic tissues and, as a consequence, to the increasing dissemination of inflammation throughout the body. The heat shock (HS) response and its associated expression of the 70 kDa family of heat shock proteins (HSP70), which are anti-inflammatory molecular chaperones, are found to be markedly decreased during muscle inactivity and aging, while evidence supports the loss of HSP70 as a key mechanism which may drive muscle atrophy, contractile dysfunction, and reduced regenerative capacity. In addition, abnormal stress response is linked with higher incidence of neurodegenerative diseases as well as low-grade inflammatory diseases that are associated with physical inactivity and obesity. Therefore, strategies to increase or, at least, to maintain the levels of HSP70, and its accompanying HS response to stress, are key to reduce biological cell dysfunctions that occur in aging. In this sense, physical exercise is of note as it is the most powerful inducer of the HS response, comparable only to heat stress and fever-like conditions. On the other hand, the amino acid L-glutamine, whose production within the skeletal muscle and liberation into the blood stream is dependent on muscle activity, is a potentializer of HSP70 expression and HS response, particularly via its entering in hexosamine biosynthetic pathway (HBP). Herein, we discuss the collaborative role of glutamine (and its donors/precursors) and physical exercise (mostly responsible for glutamine release into the circulation) as potential tools to increase HSP70 expression and the HS response in the elderly.

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“…Moreover, other markers of disease such as glycated haemoglobin (Krause et al . ), total cholesterol and LDL cholesterol (Gryka et al . ) have been shown to decrease with heat therapy.…”

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confidence: 99%