Heat shock proteins and exercise: a primer

Noble, Earl G.; Milne, Kevin; Melling, C.W. James

doi:10.1139/h08-069

Cited by 137 publications

(124 citation statements)

References 159 publications

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“…Heat shock proteins (or stress proteins) are part of an endogenous defence system within the body, which help to protect protein assembly and folding in stressed cells and to maintain cell integrity by acting as molecular chaperones (5). When the cell is severely damaged or necrotic, HSPs are released into the cytoplasm to stimulate infl ammatory cytokine generation (6). Of all HSPs, the HSP70 protein family is known to be the most inducible by stress (7), and the overexpression of renal HSP70 is associated with salt-sensitive hypertension induced by chronic angiotensin II and L-NAME administration (8)(9)(10).…”

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confidence: 99%

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Protective Effect of Aerobic Exercise Against L-Name-Induced Kidney Damage in Rats

Peeri

Habibian

Azarbayjani

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Exercise, alone or combined with changes in lifestyle, can prevent or reduce the need for pharmacotherapy in patients with compromised endothelium-dependent function. The aim of this study was to examine the protective effect of aerobic exercise against (L-NAME)-kidney damage in male rats induced by Nω-nitro-L-arginine methyl ester (L-NAME). L-NAME was administered to rats intraperitoneally in doses of 10 mg kg -1 six days a week over eight weeks. Rats exercised by running on a treadmill at the speed of (15 to 22) m min -1 , 25 min to 64 min per day, fi ve days a week over eight weeks. The rats were killed 48 h after the last dose, and their kidneys removed and homogenised to measure the levels of heat shock protein70 (HSP70), superoxide dismutase activity (SOD), and thiobarbituric acid reactive substances (TBARS). We also measured serum nitrite/nitrate. Chronic administration of L-NAME signifi cantly increased renal HSP70 and TBARS levels and decreased renal SOD activity and serum nitrites/nitrates. Training modifi ed abnormal renal HSP70, lowered TBARS, and increased SOD and serum nitrite/nitrate. Our results have confi rmed that regular aerobic exercise protects against nitric oxide defi ciency-induced kidney damage by modifying HSP70, up-regulating SOD activity, and depleting TBARS. Arh Hig Rada Toksikol 2013;64:229-235 KEY WORDS: heat shock protein70, nitric oxide, renal injury, superoxide dismutase Peeri M, et al. EXERCISE EFFECTS ON L-NAME-INDUCED KIDNEY INJURIES

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confidence: 99%

“…Because of inherent physiological stress associated with it, physical exercise can benefi cially affect a number of tissues (6). Endurance training up-regulates HSP72 expression in multiple organs, protecting them against heatstroke damage and/or it offsets some adverse effects of diabetes (11,12).…”

mentioning

confidence: 99%

Protective Effect of Aerobic Exercise Against L-Name-Induced Kidney Damage in Rats

Peeri

Habibian

Azarbayjani

et al. 2013

Archives of Industrial Hygiene and Toxicology

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“…Molecular weight is used for the classification of HSP (Nobel et al, 2008). They act as cytoprotective proteins and are having the ability to upsurge stress tolerance and enhance survival rates of heat stressed birds (Latchman, 2001).…”

Section: Resultsmentioning

confidence: 99%

Combined supplementation of organic acid blend and mannanoligosaccharide suppresses expression of heat shock protein 70 in broilers

Saleem

Masood

Zaneb

et al. 2018

IJAR

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This study investigates the effects of mannanoligosaccharide (MOS) and organic acid blend (OAB) supplementation individually and in combination on small intestinal microbiota and expression of heat shock protein 70 in Hubbard chicks. 128 day-old birds were divided into four different groups with each group having 4 replicates in a trial of 35 days. The first group was kept as control whereas, the second and third groups were given MOS and OAB respectively. The fourth group (MOS+OAB) was given combination of MOS and OAB. At the end of trial, two birds from each replicate were slaughtered. The number of lactic acid bacteria and yeast were significantly higher in MOS+OAB birds compared to other groups. Expression of heat shock protein 70 significantly decreased by MOS and OAB individually and in combination. It is concluded that combined supplementation of MOS and OAB is beneficial in broilers.

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“…Unfortunately, specific sex comparisons were not reported in that study, so it is unknown if there were differences between men and women in the magnitude of the HSP70 response. Furthermore, it is unknown if these authors controlled for the estrus cycle, which may influence the HSP70 response to exercise (29). Also, our study only examined the independent effects of both estrogen and progesterone on skeletal muscle HSP70 expression, and the combined effects of these ovarian sex hormones at physiological concentrations remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus

Bombardier¹,

Vigna²,

Iqbal³

et al. 2009

Journal of Applied Physiology

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Bombardier E, Vigna C, Iqbal S, Tiidus PM, Tupling AR. Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus. J Appl Physiol 106: 2009 -2015, 2009. First published April 9, 2009 doi:10.1152/japplphysiol.91573.2008This study examined the influence of the ovarian sex hormones, estrogen and progesterone, on the fiber-type-specific response of the inducible 70-kDa heat shock protein (HSP70) to damaging exercise in rat soleus. Ovariectomized female rats were divided into three treatment groups (n ϭ 16 per group): sham (S), progesterone (P; 25 mg pellet), and estrogen (E; 0.25 mg pellet). Each treatment group was divided into control and exercised groups. After 8 days of sham or hormone treatment, animals ran downhill intermittently for 90 min (17 m/min, Ϫ13.5°grade) on a treadmill, and soleus muscles were removed 24 h postexercise. HSP70 expression was assessed in whole muscle homogenates by Western blotting and in individual muscle fiber types by immunohistochemical analysis of serial cross sections of soleus samples. Comparisons between control groups showed that HSP70 expression in soleus was increased (P Ͻ 0.05) in E compared with both S and P. No difference (P Ͼ 0.05) was observed between S and P. Following downhill running, HSP70 content in soleus was increased (P Ͻ 0.05) compared with control in S and P, but not (P Ͼ 0.05) in E. As a result, soleus HSP70 content following downhill running was not different (P Ͼ 0.05) between any of the treatment groups. Under all conditions, HSP70 content was higher in type I vs. type II fibers, and the effects of both estrogen and exercise on HSP70 expression in soleus were also more pronounced in type I vs. type II fibers. These results demonstrate that 1) estrogen regulates HSP70 expression in skeletal muscle, increasing basal HSP70 expression and preventing further increases in HSP70 in response to exercise; 2) progesterone is not involved in the regulation of HSP70 expression in skeletal muscle; and 3) the effects of estrogen and exercise on HSP70 expression in skeletal muscle are fiber type specific. estrogen; progesterone; muscle fiber type HEAT SHOCK PROTEINS (HSP) are families of highly conserved stress proteins found in almost all cells, which have been shown to be induced by a variety of environmental and intracellular stresses (18). The inducible 70-kDa HSP (HSP70) may be the most highly induced protein of the cellular stress response and is rapidly upregulated under conditions of oxidative stress (48). It is well established that HSP70 content in skeletal muscle increases in response to both nondamaging and damaging exercise and can protect against contraction-induced muscle damage (for review, see Refs. 10,19). However, the HSP70 response to exercise in both skeletal (31, 33) and cardiac muscle (32) is sex specific, with males demonstrating a more robust response than females. Collectively, these studies and others have shown that the sex-specific HSP70 response to exercise is mediated by the ovarian sex hormo...

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Heat shock proteins and exercise: a primer

Cited by 137 publications

References 159 publications

Protective Effect of Aerobic Exercise Against L-Name-Induced Kidney Damage in Rats

Protective Effect of Aerobic Exercise Against L-Name-Induced Kidney Damage in Rats

Combined supplementation of organic acid blend and mannanoligosaccharide suppresses expression of heat shock protein 70 in broilers

Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus

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