Heat shock proteins and Drosophila aging

Tower, John

doi:10.1016/j.exger.2010.09.002

Cited by 145 publications

(115 citation statements)

References 160 publications

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“…Although the molecular mechanisms involved remain obscure, it is likely that loss of cell viability following heat shock is due in part to the formation of toxic protein aggregates, deriving from misfolded or heat-denatured proteins (Riezman, 2004). HSPs are modulators of stress resistance and ageing in flies (Tower, 2011). HSPs bind their substrates and either prevent their aggregation, catalyse their refolding or deaggregation, or target them for proteasomal or autophagic degradation (reviewed in Stetler et al, 2010).…”

Section: Autophagy Against Heat Shock and Accumulation Of Protein Aggmentioning

confidence: 99%

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki

Markaki

Tavernarakis

2013

Ageing Research Reviews

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a b s t r a c tAgeing in diverse species ranging from yeast to humans is associated with the gradual, lifelong accumulation of molecular and cellular damage. Autophagy, a conserved lysosomal, self-destructive process involved in protein and organelle degradation, plays an essential role in both cellular and whole-animal homeostasis. Accumulating evidence now indicates that autophagic degradation declines with age and this gradual reduction of autophagy might have a causative role in the functional deterioration of biological systems during ageing. Indeed, loss of autophagy gene function significantly influences longevity. Moreover, genetic or pharmacological manipulations that extend lifespan in model organisms often activate autophagy. Interestingly, conserved signalling pathways and environmental factors that regulate ageing, such as the insulin/IGF-1 signalling pathway and oxidative stress response pathways converge on autophagy. In this article, we survey recent findings in invertebrates that contribute to advance our understanding of the molecular links between autophagy and the regulation of ageing. In addition, we consider related mechanisms in other organisms and discuss their similarities and idiosyncratic features in a comparative manner.

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Section: Autophagy Against Heat Shock and Accumulation Of Protein Aggmentioning

confidence: 99%

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki

Markaki

Tavernarakis

2013

Ageing Research Reviews

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“…49,50 In the case of green tea, its polyphenols have been shown to have pro-oxidant activities 46 and thus may actually be mildly toxic, consistent with hormesis as a plausible mechanism of action.…”

Section: -48mentioning

confidence: 99%

Green Tea Polyphenols Extend the Lifespan of MaleDrosophila melanogasterWhile Impairing Reproductive Fitness

Lopez

Schriner

Okoro

et al. 2014

Journal of Medicinal Food

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Green tea is a popular beverage believed to have many health benefits, including a reduction in the risks of heart disease and cancer. Rich in polyphenolic compounds known as catechins, green tea and its components have been shown to increase the lifespan of various animal models, including Drosophila melanogaster. Here, we investigated the genderspecific effects of green tea on the lifespan of fruit flies and observed that green tea extended the lifespan of male flies only. This effect was found to be independent of typical aging interventions, such as dietary restriction, modulation of oxidative energy metabolism, and improved tolerance to environmental stresses. The one exception was that green tea did protect male flies against iron toxicity. Since there is an inverse correlation between lifespan and reproduction, the impact of green tea on male reproductive fitness was also investigated. We found that green tea negatively impacted male fertility as shown by a reduced number of offspring produced and increased mating latency. We further identified that the lifespan extension properties of green tea was only observed in the presence of females which alludes to a reproductive (or mating) dependent mechanism. Our findings suggest that green tea extends the lifespan of male flies by inhibiting reproductive potential, possibly by limiting iron uptake. To our knowledge, our study is the first to report the negative impact of green tea on Drosophila male reproduction. Our results also support previous studies that suggest that green tea might have a negative effect on reproductive fitness in humans.

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“…Most Hsp expression patterns under adverse conditions and during development have been characterized in Drosophila species and a few other model insects (Ashok Kumar et al 2014;Kregel 2002;Tower 2011). Hsp expression profiles are lacking for many insect groups including Lepidoptera, which include several of the most important pest species.…”

Section: Introductionmentioning

confidence: 99%

Response of heat shock protein genes of the oriental fruit moth under diapause and thermal stress reveals multiple patterns dependent on the nature of stress exposure

Zhang

Peng

Zheng

et al. 2016

Cell Stress and Chaperones

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Heat shock protein gene (Hsp) families are thought to be important in thermal adaptation, but their expression patterns under various thermal stresses have still been poorly characterized outside of model systems. We have therefore characterized Hsp genes and their stress responses in the oriental fruit moth (OFM), Grapholita molesta, a widespread global orchard pest, and compared patterns of expression in this species to that of other insects. Genes from four Hsp families showed variable expression levels among tissues and developmental stages. Members of the Hsp40, 70, and 90 families were highly expressed under short exposures to heat and cold. Expression of Hsp40, 70, and Hsc70 family members increased in OFM undergoing diapause, while Hsp90 was downregulated. We found that there was strong sequence conservation of members of large Hsp families (Hsp40, Hsp60, Hsp70, Hsc70) across taxa, but this was not always matched by conservation of expression patterns. When the large Hsps as well as small Hsps from OFM were compared under acute and ramping heat stress, two groups of sHsps expression patterns were apparent, depending on whether expression increased or decreased immediately after stress exposure. These results highlight potential differences in conservation of function as opposed to sequence in this gene family and also point to Hsp genes potentially useful as bioindicators of diapause and thermal stress in OFM.

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Heat shock proteins and Drosophila aging

Cited by 145 publications

References 160 publications

Autophagy and ageing: Insights from invertebrate model organisms

Autophagy and ageing: Insights from invertebrate model organisms

Green Tea Polyphenols Extend the Lifespan of MaleDrosophila melanogasterWhile Impairing Reproductive Fitness

Response of heat shock protein genes of the oriental fruit moth under diapause and thermal stress reveals multiple patterns dependent on the nature of stress exposure

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