Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma

Fu, Wei; Zhang, Jin Fang; Wang, Hua; Xi, Zhi chao; Wang, Wei Mao; Zhuang, Pengwei; Zhu, Xiaofeng; Chen, Shih‐Chi; Chan, Tak Ming; Leung, Kwong Sak; Lü, Gang; Hong, Xu; Kung, Hsiang Fu

doi:10.1016/j.jprot.2012.05.032

Cited by 37 publications

(30 citation statements)

References 31 publications

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“…In this research, TDP is reported to induce apoptosis of cells by targeting the heat shock protein 27 (Hsp27) related signaling pathway (81). In another study, TDP was proved to lead to apoptosis of cells through activation of the mitochondrial signaling pathway (82).…”

Section: Xanthonementioning

confidence: 93%

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

Xia

Chen

Zhang

et al. 2014

DD^|^T

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Section: Xanthonementioning

confidence: 93%

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

Xia

Chen

Zhang

et al. 2014

DD^|^T

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“…Furthermore, the mechanisms of action of some compounds involve the induction of apoptosis, inhibition of autophagic flux, cell cycle arrest, and modulation of oncogenes, etc. [30][31][32][33]. Recently, we constructed HeLa cells stably expressing GFP-LC3 combined with HCS to identify autophagy regulators from microRNAs and natural compounds from Garcinia species [34,35].…”

Section: Abbreviationsmentioning

confidence: 99%

Identification and Characterization of Anticancer Compounds Targeting Apoptosis and Autophagy from Chinese Native Garcinia Species

Lao

et al. 2014

Planta Med

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Natural compounds from medicinal plants are important resources for drug development. Active compounds targeting apoptosis and autophagy are candidates for anti-cancer drugs. In this study, we collected Garcinia species from China and extracted them into water or ethanol fractions. Then, we performed a functional screen in search of novel apoptosis and autophagy regulators. We first characterized the anti-proliferation activity of the crude extracts on multiple cell lines. HeLa cells expressing GFP-LC3 were used to examine the effects of the crude extracts on autophagy. Their activities were confirmed by Western blots of A549 and HeLa cells. By using bioassay guided fractionation, we found that two caged prenylxanthones from Garcinia bracteata, neobractatin and isobractatin, can significantly induce apoptosis and inhibit autophagy. Our results suggest that different Garcinia species displayed various degrees of toxicity on different cancer cell lines. Furthermore, the use of a high content screening assay to screen natural products was an essential method to identify novel autophagy regulators.

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“…Functional studies showed that HSP27 mediated cell death induced by TDP in vitro. Furthermore, a nude mice model also demonstrated the suppressive effect of TDP on HCC [27]. These data suggests that TDP induces apoptosis by repressing HSP27 expression, which was associated with the caspase-dependent pathway.…”

Section: Targeting Of Hsp27 By Xanthones From Garcinia Oblongifoliainmentioning

confidence: 70%

HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer

Aréchaga-Ocampo

López‐Camarillo

2015

Heat Shock Proteins

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Heat shock proteins (HSP) are a family of evolutionary conserved proteins induced by cellular stressors. HSP are essential players in the development and progression of cancer inducing resistance to conventional treatment in a wide range of human tumors. Overexpression of HSP27, a member of HSP family, is associated with apoptosis inhibition, enhanced migration and metastasis and several clinical features of cancer including drug resistance promotion. At present, HSP27 could be a promising strategy to enhance sensitivity of tumors to cancer treatment. A plethora of novel compounds present in the diet, including flavonoids, can efficiently inhibit the growth of tumor cells by acting as natural "chemopreventers". Many works reported the efficient targeting of HSP27 by using small inhibitors and dietary natural compounds in order to enhance the effectiveness of cancer therapies. In this chapter, we reviewed the current status of treatments based in dietary components targeting HSP27 as a novel strategy to circumvent chemotherapy cytotoxicity in cancer patients. Moreover we addressed the current status of HSP27 overexpression in many types of human cancers and highlighted the prominent role of targeting HSP27 as a novel therapeutic strategy in cancer.

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Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma

Cited by 37 publications

References 31 publications

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

Identification and Characterization of Anticancer Compounds Targeting Apoptosis and Autophagy from Chinese Native Garcinia Species

HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer

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