Heat shock pretreatment induced cadmium resistance in the nematode Caenorhabditis elegans is depend on transcription factors DAF-16 and HSF-1

Wang, Shunchang; You, Mu; Wang, Chengrun; Zhang, Yuecheng; Fan, Caiqi; Yan, Shoubao

doi:10.1016/j.envpol.2020.114081

Cited by 11 publications

(10 citation statements)

References 46 publications

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“…Then the nematodes were anesthetized by sodium azide with a 3% agarose pad and observed under a fluorescence microscope (Leica, Wetzlar, Germany). The fluorescence intensity of HSP‐16.2::GFP was monitored by Image J software 33 …”

Section: Methodsmentioning

confidence: 99%

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

et al. 2021

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Tangeretin is a polymethoxylated flavonoid naturally occurred in citrus fruits with many pharmacological activities, such as anti‐inflammatory, antiproliferative, and neuroprotective properties. A previous study reported that tangeretin‐enriched orange extract could prolong the lifespan in Caenorhabditis elegans. However, the antiaging effect of tangeretin remains uncertain. In this study, we used the model organism C. elegans to conduct a lifespan test, observed the aging‐related functional changes of nematodes, the fluorescence changes of stress‐related proteins (DAF‐16 and HSP‐16.2) and its response to stress assay, and monitored the effect of tangeretin on the mRNA expression levels. The results showed that tangeretin supplementation (30 and 100 μM) extended the mean lifespan, slowed aging‐related functional declines, and increased the resistance against heat‐shock stress. Furthermore, tangeretin upregulated the mRNA expression of daf‐16, hsp‐16.2, and hsp‐16.49, promoted the nuclear localization of DAF‐16, and enhanced the fluorescence intensity of HSP‐16.2, while it had no effect on the lifespan of daf‐2, age‐1, and daf‐16 mutants. The current findings suggest that tangeretin can significantly extend the lifespan and enhance heat stress tolerance in an insulin/insulin‐like growth factor signaling dependent manner.

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Section: Methodsmentioning

confidence: 99%

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

et al. 2021

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“…It then undergoes homotrimerization and activates transcription by binding to heat shock elements (HSE) on the DNA. 136 HSP-1 also plays a role in inhibiting the transcription of proinflammatory genes such as IL-1β, IL-6, and TNFα. 137,138 Wang et al, 136 showed that MK2 can phosphorylate HSF-1 reducing the ability to bind to HSE and increasing its affinity to HSP90 thus inhibiting HSP1 function.…”

Section: Transcriptionmentioning

confidence: 99%

“…136 HSP-1 also plays a role in inhibiting the transcription of proinflammatory genes such as IL-1β, IL-6, and TNFα. 137,138 Wang et al, 136 showed that MK2 can phosphorylate HSF-1 reducing the ability to bind to HSE and increasing its affinity to HSP90 thus inhibiting HSP1 function. Therefore, MK2 influences transcription by inhibiting repressors of inflammatory signaling.…”

Section: Transcriptionmentioning

confidence: 99%

Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer

Morgan

Berggren

Spiess

et al. 2021

Molecular Carcinogenesis

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“…Phosphorylated DAF-16 is inactivated by isolation from the cytoplasm, while non-phosphorylated DAF-16 targets the nucleus and controls the expression of genes participating in metabolism, immune defense, and stress resistance. The DAF-16/FOXO nuclear localization can be caused by starvation, heat, and oxidative stress [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans

Song

Xie

et al. 2022

Foods

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For this investigation, Caenorhabditis elegans (C. elegans) served, for the first time, as a model organism to evaluate the toxic effect and possible underlying mechanisms under acrolein (ACR) exposure. The results showed that ACR exposure (12.5–100 μM) shortened the lifespan of C. elegans. The reproductive capacity, body length, body width, and locomotive behavior (head thrash) of C. elegans were diminished by ACR, especially the doses of 50 and 100 μM. Furthermore, ACR significantly enhanced the endogenous ROS levels of C. elegans, inhibited the antioxidant-related enzyme activities, and affected the expression of antioxidant related genes. The increasing oxidative stress level promoted the migration of DAF-16 into the nucleus that was related to the DAF-16/FOXO pathway. It was also confirmed by the significant decrease of the lifespan-shortening trend in the daf-16 knockout mutant. In conclusion, ACR exposure induced aging and oxidative stress in C.elegans, resulting in aging-related decline and defense-related DAF-16/FOXO pathways’ activation.

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Heat shock pretreatment induced cadmium resistance in the nematode Caenorhabditis elegans is depend on transcription factors DAF-16 and HSF-1

Cited by 11 publications

References 46 publications

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer

Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans

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