Heat-not-burn tobacco products: concerns from the Italian experience

Liu, Xiaoqiu; Lugo, Alessandra; Spizzichino, Lorenzo; Tabuchi, Takahiro; Pacifici, Roberta; Gallus, Silvano

doi:10.1136/tobaccocontrol-2017-054054

Cited by 77 publications

(108 citation statements)

References 7 publications

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“…As in the case of electronic cigarettes, this technology initially did not gain wide popularity and was discontinued shortly after its introduction. Recently, the tobacco industry has made another attempt to introduce HTPs to the market [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…In 2014, a heated tobacco system from Philip Morris International (PMI), marketed as IQOS (I-Quit-Ordinary-Smoking), was introduced [3][4][5][6]. Other tobacco companies introduced their own HTPs in 2016.…”

Section: Introductionmentioning

confidence: 99%

“…However, the potential impact of HTP use on human health has not been fully investigated yet. The prevalence of HTP use has been increasing, especially in highly developed countries such as Japan and Italy [2,3,5,6]. Based on the growth of the e-cigarette market in recent years, it is expected that the popularity of HTPs will continue to increase rapidly.…”

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confidence: 99%

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New ideas, old problems? Heated tobacco products – a systematic review

Jankowski

Brożek

Lawson

et al. 2019

Int J Occup Med Environ Health

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Heated tobacco products (HTPs) are a form of nicotine delivery intended to provide an alternative to traditional cigarettes. The aim of this systematic review was to present the current state of knowledge on HTPs with an emphasis on the potential impact of HTP use on human health. During the preparation of this systematic review, the literature on HTPs available within Medline/PubMed, EMBASE, CINAHL, ScienceDirect, and Google Scholar was retrieved and examined. In the final review, 97 research papers were included. The authors specifically assessed the construction and operation of HTPs, as well as the chemical composition of HTP tobacco sticks and the generated aerosol, based on evidence from experimental animal and cellular studies, and human-based studies. Heated tobacco products were found to generate lower concentrations of chemical compounds compared to traditional cigarettes, except for water, propylene glycol, glycerol, and acetol. The nicotine levels delivered to the aerosol by HTPs were 70-80% as those of conventional combustion. The results of in vitro and in vivo assessments of HTP aerosols revealed reduced toxicity, but these were mainly based on studies sponsored by the tobacco industry. Independent human-based studies indicated that there was a potentially harmful impact of the active and passive HTP smoking on human health. Currently, a large body of knowledge on HTP exposures and health effects is provided by the tobacco industry (52% of identified studies). Based on the available evidence, HTPs produce lower levels of toxic chemicals, compared to conventional cigarettes, but they are still not risk-free. Int J Occup Med Environ Health. 2019;32(5):595 -634

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New ideas, old problems? Heated tobacco products – a systematic review

Jankowski

Brożek

Lawson

et al. 2019

Int J Occup Med Environ Health

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“…In December 2014, PMI became the first company to make a large-scale launch of HTP, promoting IQOS. In Italy, rapid market penetration led to an increase in IQOS use, including intent to use IQOS among non-smokers and long-term former smokers who would otherwise remain tobacco-free 16 , 17 . In the case of never smokers, HTP has the potential to cause harm, despite the tobacco companies’ claim to the contrary 16 .…”

Section: Introductionmentioning

confidence: 99%

“…In Italy, rapid market penetration led to an increase in IQOS use, including intent to use IQOS among non-smokers and long-term former smokers who would otherwise remain tobacco-free 16 , 17 . In the case of never smokers, HTP has the potential to cause harm, despite the tobacco companies’ claim to the contrary 16 . The finding that non-smokers and former smokers are using IQOS illustrates how the introduction of HTP can compound the harms caused by other tobacco products.…”

Section: Introductionmentioning

confidence: 99%

Heated tobacco products: another tobacco industry global strategy to slow progress in tobacco control

Bialous

Glantz

2018

Tob Control

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There has been a global decline in tobacco consumption that, if continued, will negatively impact the tobacco industry’s profits. This decline led the industry to invent and market new products, including heated tobacco products (HTP). HTP are an extension of the industry’s strategies to undermine government’s tobacco regulatory efforts as they are being promoted as part of the solution for the tobacco epidemic. Under the moniker of ‘harm reduction’, the tobacco companies are attempting to rehabilitate their reputation so they can more effectively influence governments to roll back existing tobacco control policies or create exemptions for their HTP. Rolling back tobacco control policies will make it easier for the companies to renormalise tobacco use to increase social acceptability for all their products. When regulations are absent or when loopholes exist in classifying HTP as a tobacco product (thus subject to all tobacco control regulations), the industry’s marketing of HTP is making these products more visible to the public and more accessible. Governments need to ensure that HTP are regulated as tobacco products or drugs and reject partnerships with the tobacco companies to promote ‘harm reduction’. The tobacco companies remain the vector of the tobacco-caused epidemic and cannot be part of the global tobacco control solution.

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NIR and THz spectroscopy: An experimental investigation toward nicotine‐related devices

Bratu

Bojan

Banita

et al. 2023

Journal of Biophotonics

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This study examined the content of nicotine‐delivery products using terahertz time‐domain spectroscopy (THz‐TDS) and breath ethylene investigated with CO2 laser photoacoustic spectroscopy (CO2 LPAS) system as a biomarker of oxidative stress after smoking. The THz‐TDS method provided valuable information on the transmission spectra of tobacco and nicotine in smoking products. From the CO2 LPAS data it was observed that in cigarette (TC) smoking the mean breath ethylene was 687 parts per billion (ppb), while in electronic cigarettes and tobacco heating devices smoking the mean ethylene was 56 ppb and 48 ppb, respectively. The main finding was that TC showed higher transmission in the THz region producing a higher oxidative stress on the body.

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Heat-not-burn tobacco products: concerns from the Italian experience

Cited by 77 publications

References 7 publications

New ideas, old problems? Heated tobacco products – a systematic review

New ideas, old problems? Heated tobacco products – a systematic review

Heated tobacco products: another tobacco industry global strategy to slow progress in tobacco control

NIR and THz spectroscopy: An experimental investigation toward nicotine‐related devices

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