We are interested in this article in studying the damped wave equation with localized initial data, in the scale-invariant case with mass term and two combined nonlinearities. More precisely, we consider the following equation:with small initial data. Under some assumptions on the mass and damping coefficients, ν and µ > 0, respectively, we show that blow-up region and the lifespan bound of the solution of (E) remain the same as the ones obtained in [9] in the case of a mass-free wave equation, i.e. (E) with ν = 0. Furthermore, using in part the computations done for (E), we enhance the result in [30] on the Glassey conjecture for the solution of (E) with omitting the nonlinear term |u| q . Indeed, the blow-up region is extended from p ∈ (1, p G (N + σ)], where σ is given by (1.12) below, to p ∈ (1, p G (N + µ)] yielding, hence, a better estimate of the lifespan when (µ − 1) 2 − 4ν 2 < 1. Otherwise, the two results coincide. Finally, we may conclude that the mass term has no influence on the dynamics of (E) (resp. (E) without the nonlinear term |u| q ), and the conjecture we made in [9] on the threshold between the blow-up and the global existence regions obtained holds true here.