Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis

Toda, Kazuya; Yamauchi, Yuki; Tanaka, Azusa; Kuhara, Tetsuya; Odamaki, Toshitaka; Yoshimoto, Shin; Xiao, Jin‐zhong

doi:10.3390/nu12010219

Cited by 27 publications

(25 citation statements)

References 44 publications

(57 reference statements)

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“…The role of Bi dobacteria in muscle function has been well studied recently. An experimental study investigated the effects of Bi dobacterium breve B-3 (B-3) on muscle function on mice [35]. And it turned out that the administration of B-3 on the mouse model could increase muscle mass and affect muscle metabolism, and the grip strength of heat-killed B-3 group was signi cantly higher than that of the control group [35].…”

Section: Discussionmentioning

confidence: 99%

“…An experimental study investigated the effects of Bi dobacterium breve B-3 (B-3) on muscle function on mice [35]. And it turned out that the administration of B-3 on the mouse model could increase muscle mass and affect muscle metabolism, and the grip strength of heat-killed B-3 group was signi cantly higher than that of the control group [35]. Similarity, another study suggested that dietary supplementation with Bi dobacterium breve BR03 attenuates performance decrements and muscle tension in the days following muscle-damaging exercise [36].…”

Section: Discussionmentioning

confidence: 99%

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Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Liu¹,

Cheng²,

Wen³

et al. 2020

Preprint

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Background We aim to explore the genetic association between hand grip strength (HGS) and gut microbiota (GM). Methods The genome-wide association study (GWAS) data of GM was obtained from a recently published study, involving 2,646 individuals. Phenotypic data of left HGS (n = 375,229) and right HGS (n = 375,279) were derived from the UK Biobank. Firstly, PLINK 2.0 was used to calculate 114 GM related polygenetic risk score (PRS) of each subject based on GWAS result. Regression analysis was then conducted to evaluate the possible association of GM-PRS and HGS. Then genome-wide by environment interaction study (GWEIS) of GM related traits was then performed using a regression model adjusted for age, gender, BMI and 10 principal components. Results For PRS analysis, 13 candidate GM were identified to be associated with left HGS (P < 0.05), including G_Bifidobacterium (P = 8.36 × 10− 4), G_Clostridium_sensu_stricto (P = 2.69 × 10− 3), and 10 significant GM for right HGS, such as G_Acidaminococcus (P = 1.29 × 10− 2), G_Streptococcus (P = 1.79 × 10− 2). In addition, 4 GM were found to be overlapped in association with both left and right HGS, including G_Bifidobacterium (P right HGS = 2.78 × 10− 2, P left HGS = 8.36 × 10− 4). Furthermore, several genome-wide significant GWEIS associations were detected for HGS, including 3 significant SNPs interacted with G_Butyricicoccus (P < 5 × 10− 8) for right HGS (rs41310432, P = 3.86 × 10− 8; closest gene: NASP; rs1053941, P = 4.71 × 10− 8; closest gene: NASP; rs6671239, P = 4.73 × 10− 8, closest gene: GPBP1L1), and 1 suggestive intronic SNP in CACNA1H on chromosome 16 interacted with G_Butyricicoccus (rs139206507, P = 8.68 × 10− 8 ) for left HGS. Conclusions Our study holds great potential gaining a better understanding of the relationship between GM and HGS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Liu¹,

Cheng²,

Wen³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In another clinical study on healthy elderly subjects who were supplemented with a combination probiotic containing B. breve B-3 and assigned to moderate resistance training, the results showed that the combination probiotic containing B. breve B-3 improved mental condition, body weight, and bowel movement frequency [ 85 ]. Administration of both live and heat-killed B. breve B-3 to 8-week-old SD rats increased muscle mass and muscle strength, promoted oxidative muscle fiber composition, and modified metabolic functions, and the effects possibly occurred via the Akt and AMPK pathways [ 38 ]. In these studies, heat-killed B. breve B-3 showed equivalent or even stronger effects compared with live cells.…”

Section: Probiotics For Anti-aging Reported From Research Modelsmentioning

confidence: 99%

Gerobiotics: probiotics targeting fundamental aging processes

Tsai¹,

Cheng

Liu³

et al. 2021

Bioscience of Microbiota, Food and Health

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Aging is recognized as a common risk factor for many chronic diseases and functional decline. The newly emerging field of geroscience is an interdisciplinary field that aims to understand the molecular and cellular mechanisms of aging. Several fundamental biological processes have been proposed as hallmarks of aging. The proposition of the geroscience hypothesis is that targeting holistically these highly integrated hallmarks could be an effective approach to preventing the pathogenesis of age-related diseases jointly, thereby improving the health span of most individuals. There is a growing awareness concerning the benefits of the prophylactic use of probiotics in maintaining health and improving quality of life in the elderly population. In view of the rapid progress in geroscience research, a new emphasis on geroscience-based probiotics is in high demand, and such probiotics require extensive preclinical and clinical research to support their functional efficacy. Here we propose a new term, “gerobiotics”, to define those probiotic strains and their derived postbiotics and para-probiotics that are able to beneficially attenuate the fundamental mechanisms of aging, reduce physiological aging processes, and thereby expand the health span of the host. We provide a thorough discussion of why the coining of a new term is warranted instead of just referring to these probiotics as anti-aging probiotics or with other similar terms. In this review, we highlight the needs and importance of the new field of gerobiotics, past and currently on-going research and development in the field, biomarkers for potential targets, and recommended steps for the development of gerobiotic products. Use of gerobiotics could be a promising intervention strategy to improve health span and longevity of humans in the future.

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“…lactis DSM10140 In vitro Suppression of PI3K/Akt signal pathway over-activation Regulation of Salmonella induced IL-8 response and prevention of Salmonella infection 2016 44 B. animalis subsp. animalis (IM386) In vitro and in vivo Up-regulation of PKC and PI3K/Akt anti-apoptotic pathways Regulation of TJ and actin cytoskeleton, and promotion of general immune tolerance 2021 34 B. breve B-3 In vivo Promotion of AMPK and Akt/mTOR signaling phosphorylation Elevation muscle mass 2020 57 B. breve C50 (BbC50sn) In vitro Induction of PI3K/Akt, p38MAPK, and ERK pathways reduction of allergic and inflammatory disorders 2008 58 L. johnsonii N6.2 In vivo Reduction of mTORC1-activating phosphorylation of pAKT-T308 and pAKT-S473 Reduction of metabolic syndrome disease 2018 59 L. casei In vitro Down-regulation of PI3K/Akt/NF-κB phosphorylation Induction of apoptosis and inhibition of gastric cancer 2013 60 L. casei Zhang (LCZ) In vivo Decreasing inflammatory cytokines, and inhibiting the hyperactivation of PI3K/Akt/NF-κB and p -STAT3 pathways Prevention and treatment of ulcerative colitis 2019 95 L. paracasei subp. paracasei X12 In vitro ...…”

Section: Introductionmentioning

confidence: 99%

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

et al. 2021

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The mammalian target of rapamycin (mTOR) and the phosphatidylinositol-3-kinase (PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but somewhat interconnected significant immune pathways which play complex roles in a variety of physiological processes as well as pathological conditions. Aberrant activation of PI3K/Akt/mTOR signaling pathways has been reported to be associated in a wide variety of human diseases. Over the past few years, growing evidence in in vitro and in vivo models suggest that this sophisticated and subtle cascade mediates the orchestration of the immune response in health and disease through exposure to probiotics. An expanding body of literature has highlighted the contribution of probiotics and PI3K/Akt/mTOR signaling pathways in gastrointestinal disorders, metabolic syndrome, skin diseases, allergy, salmonella infection, and aging. However, longitudinal human studies are possibly required to verify more conclusively whether the investigational tools used to understand the regulation of these pathways might provide effective approaches in the prevention and treatment of various disorders. In this Review, we summarize the experimental evidence from recent peer-reviewed studies and provide a brief overview of the causal relationship between the effects of probiotics and their metabolites on the components of PI3K/Akt/mTOR signaling pathways and human disease.

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Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis

Cited by 27 publications

References 44 publications

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

Gerobiotics: probiotics targeting fundamental aging processes

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

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