Heat-induced saliva secretion and thermoregulation in female rats with ventromedial hypothalamic lesions

Flynn, Francis W.; Evey, Loren A.; Mitchell, James C.

doi:10.1016/0031-9384(81)90098-6

Cited by 13 publications

(4 citation statements)

References 18 publications

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“…Details of the pathways from the anterior hypothalamus to the superior salivatory nucleus are still unclear. Thermal salivation was diminished by lesions in anterior hypothalamus [142], the lateral hypothalamus [128] and the ventromedial hypothalamus [36]. The lateral hypothalamus provides input to the superior salivary nucleus [117].…”

Section: Salivary Secretion and Saliva Spreading Behaviormentioning

confidence: 99%

Central nervous system circuits that control body temperature

Madden

Morrison

2019

Neuroscience Letters

115

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Maintenance of mammalian core body temperature within a narrow range is a fundamental homeostatic process to optimize cellular and tissue function, and to improve survival in adverse thermal environments. Body temperature is maintained during a broad range of environmental and physiological challenges by central nervous system circuits that process thermal afferent inputs from the skin and the body core to control the activity of thermoeffectors. These include thermoregulatory behaviors, cutaneous vasomotion (vasoconstriction and, in humans, active vasodilation), thermogenesis (shivering and brown adipose tissue), evaporative heat loss (salivary spreading in rodents, and human sweating). This review provides an overview of the central nervous system circuits for thermoregulatory reflex regulation of thermoeffectors.

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Section: Salivary Secretion and Saliva Spreading Behaviormentioning

confidence: 99%

Central nervous system circuits that control body temperature

Madden

Morrison

2019

Neuroscience Letters

115

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“…An efficient thermoregulatory grooming behavior depends on increase in the salivary production, making grooming a mixed autonomic/behavioral thermoeffector. Some brain regions have been reported to be involved in salivation, such as lateral, 42 anterior, 43 and ventromedial hypothalamus, 44 and the periventricular AV3V. 35,45,46 In these studies, it has been shown that lesion in these areas promotes decrease in heat-induced salivation level and, consequently, deficiency in heat loss, promoting increase in T c .…”

Section: Behavioral Thermoregulationmentioning

confidence: 99%

Current understanding on the neurophysiology of behavioral thermoregulation

2015

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Temperature influence on the physiology and biochemistry of living organisms has long been recognized, which propels research in the field of thermoregulation. With the cloning and characterization of the transient receptor potential (TRP) ion channels as the principal temperature sensors of the mammalian somatosensory neurons, the understanding, at a molecular level, of thermosensory and thermoregulatory mechanisms became promising. Because thermal environment can be extremely hostile (temperature range on earth's surface is from ∼ −69°C to 58°C), living organisms developed an array of thermoregulatory strategies to guarantee survival, which include both autonomic mechanisms, which aim at increasing or decreasing heat exchange between body, and ambient and behavioral strategies. The knowledge regarding neural mechanisms involved in autonomic thermoregulatory strategies has progressed immensely compared to the knowledge on behavioral thermoregulation. This review aims at collecting the up-to-date knowledge on the neural basis for behavioral thermoregulation in mammals in order to point out perspectives and deployment of this research field.

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“…Numerous projections exist from the lateral hypothalamus to salivary nuclei located in the brain stem (4,5). Lesions of the lateral or ventromedial hypothalamus impair salivary secretion induced by increased ambient temperature in rats (5,6). Also, other experiments have demonstrated that warming or electrical stimulation of the preoptic area produces an increase in salivary secretion by the submandibular and sublingual glands (7), and lesions in the anteroventral third ventricle region reduce salivary secretion induced by pilocarpine injected intraperitoneally (ip) or icv (3).…”

Section: Introductionmentioning

confidence: 99%

Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission

Fernández‐Solari

Prestifilippo

Vissio

et al. 2009

Braz J Med Biol Res

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Our objective was to determine the effect of arachidonylethanolamide (anandamide, AEA) injected intracerebroventricularly (icv) into the lateral ventricle of the rat brain on submandibular gland (SMG) salivary secretion. Parasympathetic decentralization (PSD) produced by cutting the chorda tympani nerve strongly inhibited methacholine (MC)-induced salivary secretion while sympathetic denervation (SD) produced by removing the superior cervical ganglia reduced it slightly. Also, AEA (50 ng/5 μL, icv) significantly decreased MC-induced salivary secretion in intact rats (MC 1 μg/kg: control (C), 5.3 ± 0.6 vs AEA, 2.7 ± 0.6 mg; MC 3 μg/kg: C, 17.6 ± 1.0 vs AEA, 8.7 ± 0.9 mg; MC 10 μg/kg: C, 37.4 ± 1.2 vs AEA, 22.9 ± 2.6 mg). However, AEA did not alter the significantly reduced salivary secretion in rats with PSD, but decreased the slightly reduced salivary secretion in rats with SD (MC 1 μg/kg: C, 3.8 ± 0.8 vs AEA, 1.4 ± 0.6 mg; MC 3 μg/kg: C, 14.7 ± 2.4 vs AEA, 6.9 ± 1.2 mg; P < 0.05; MC 10 μg/kg: C, 39.5 ± 1.0 vs AEA, 22.3 ± 0.5 mg; P < 0.001). We showed that the inhibitory effect of AEA is mediated by cannabinoid type 1 CB1 receptors and involves GABAergic neurotransmission, since it was blocked by previous injection of the CB1 receptor antagonist AM251 (500 ng/5 μL, icv) or of the GABA A receptor antagonist, bicuculline (25 ng/5 μL, icv). Our results suggest that parasympathetic neurotransmission from the central nervous system to the SMG can be inhibited by endocannabinoid and GABAergic systems.

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Heat-induced saliva secretion and thermoregulation in female rats with ventromedial hypothalamic lesions

Cited by 13 publications

References 18 publications

Central nervous system circuits that control body temperature

Central nervous system circuits that control body temperature

Current understanding on the neurophysiology of behavioral thermoregulation

Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission

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