Heat Illness

Tek, Deniz; Olshaker, Jonathan S.

doi:10.1016/s0733-8627(20)30714-8

Cited by 46 publications

(5 citation statements)

References 31 publications

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“…Although salicylates are recognized as anti-pyretic medications in the management of fever, this is accomplished through modulation of the hypothalamic temperature setpoint. Unlike fever, hyperthermia in heat stroke is not caused by hypothalamic dysfunction, and thus antipyretics, such as aspirin, have no benefit, and in fact, can worsen associated coagulopathy and liver dysfunction (15).…”

Section: Impact Of Cardiac Medications On Heat Strokementioning

confidence: 99%

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The Cardiovascular System in Heat Stroke

Marchand

Gin

2022

CJC Open

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Impact Of Cardiac Medications On Heat Strokementioning

confidence: 99%

“…Unlike fever, hyperthermia in heat stroke is not caused by hypothalamic dysfunction, and thus antipyretics, such as aspirin, have no benefit, and in fact, can worsen associated coagulopathy and liver dysfunction. 15 …”

Section: Impact Of Cardiac Medications On Heat Strokementioning

confidence: 99%

The Cardiovascular System in Heat Stroke

Marchand

Gin

2022

CJC Open

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“…Furthermore, despite numerous animal studies affirming the favorable efficacy of anti-inflammatory and anti-endotoxic agents for HS, their translation into clinical success remains limited. Aspirin, despite demonstrating effectiveness against heat-induced injury in avian cardiac tissues, fails to manifest any clinical benefit and may potentially exacerbate coagulation disorders and hepatic dysfunction ( Tek and Olshaker, 1992 ). Individuals with cardiovascular ailments not only contend with the vulnerability of their cardiac systems in the face of HS but also grapple with an elevated risk due to commonly prescribed cardiac medications.…”

Section: Discussionmentioning

confidence: 99%

The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury

Xia,

Sun,

et al. 2024

Front. Pharmacol.

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Heat stroke (HS) is a febrile illness characterized by an elevation in the core body temperature to over 40°C, accompanied by central nervous system impairment and subsequent multi-organ dysfunction syndrome. In recent years, the mortality rate from HS has been increasing as ambient temperatures continue to rise each year. The cardiovascular system plays an important role in the pathogenesis process of HS, as it functions as one of the key system for thermoregulation and its stability is associated with the severity of HS. Systemic inflammatory response and endothelial cell damage constitute pivotal attributes of HS, other factors such as ferroptosis, disturbances in myocardial metabolism and heat shock protein dysregulation are also involved in the damage to myocardial tissue in HS. In this review, a comprehensively detailed description of the pathogenesis of HS-induced myocardial injury is provided. The current treatment strategies and the promising therapeutic targets for HS are also discussed.

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“…Alcohol may get absorbed by dilated skin vessels and may cause toxicity, whereas those anti pyritic medications, aspirin, and paracetamol are not useful in heat stroke patients as the mechanism does not involve a change in the hypothalamic set point. These may cause adverse effects on the liver [5,7,8].…”

Section: Managementmentioning

confidence: 99%

“…Cooling measures should be stopped once a temperature of 38 or 39C is achieved in order to reduce the iatrogenic hypothermia [8].…”

Section: Managementmentioning

confidence: 99%

Acute Management of Heat Stroke: Facts and Figures

Al-Ameri,

Salem,

Alessai

et al. 2024

Heat Illness and Critical Care

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Heat-related illnesses range from heat exhaustion to heat stroke. Heat stroke is a life-threatening medical emergency causing multiple organ dysfunction that if not treated, can be fatal. It is a severe heat illness with a body temperature of more than 400c and organ dysfunction. Epidemiology of heat stroke varies depending on geographic location, and reported incidences range from 1.98 to 2.89/100000 per year. Heat stroke is classified as exertional or non-exertional. Pathophysiology is exposure to higher temperatures with impaired thermoregulation. Patients will present with high core body temperature; tachypnea, tachycardia, and hypotension may be present. The manifestations of organ dysfunction range from coagulopathy to altered levels of consciousness, and pulmonary edema. Accurate core body temperature measurement with clinical manifestations will diagnose the heat stroke. Early diagnosis, earlier temperature management, and organ supportive care are essential.

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Heat Illness

Cited by 46 publications

References 31 publications

The Cardiovascular System in Heat Stroke

The Cardiovascular System in Heat Stroke

The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury

Acute Management of Heat Stroke: Facts and Figures

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